Technology

Cook Biotech is working with numerous natural tissues to develop advanced biomaterials. One such biomaterial being used extensively is small intestinal submucosa – also called SIS – which is a strong, pliable tissue taken from porcine intestine that provides a scaffold for patient cells to repair damaged tissue.

What is SIS technology?

Imagine an advanced biomaterial that supports tissue repair with a scaffold-like matrix that has an all natural structure and composition—a biomaterial that does not encapsulate when surgically implanted, but is gradually remodeled, leaving behind organized tissue.

SIS technology supports remodeling with the added benefits of long-term strength, ease of use, and cost effectiveness. SIS is an extracellular matrix that combines the flexibility of nature with the precision of science to help the body restore itself.

What is an extracellular matrix (ECM)?

The ECM is the structural and functional substance that surrounds cells in nearly all tissues in the body. A three-dimensional matrix, ECM supports cells in addition to playing other vital roles. While the composition of the ECM varies by tissue, it is generally composed of four major types of molecules:

  • Structural proteins, such as collagen and elastin
  • Glycoproteins, such as fibronectin and laminin
  • Glycosaminoglycans (GAGs) and proteoglycans, such as hyaluronan, heparan sulfate, heparin and dermatan sulfate
  • Matricellular proteins, such as thrombospondins, osteopontin, and tenascins

Collagen provides the main structural framework in natural living tissue and is the most abundant protein in the ECM. GAGs and proteoglycans keep the matrix well hydrated by absorbing water and also bind growth factors, which are important for cell signaling. Matricellular proteins add additional functional utility to the ECM.

What is the role of the ECM in tissue repair?

ECM has been viewed as a support structure upon which cells orient and move themselves in response to other cells. But ECM is more than that. It also provides the architectural structure and the environment necessary for tissue repair.

The tissue-repair processes occur through the coordinated activity of the cells that reside within the ECM.

As the ECM is necessary for tissue maintenance, it also plays a major role in tissue repair. Without a functional ECM, repair is stalled, as the ECM is no longer able to support the normal cellular processes.

Where do SIS products come from?

Origin

SIS tissue-repair products are biologic grafts created from porcine small intestinal submucosa (SIS). The submucosa is located between the mucosal and muscular layers of the small intestine. The submucosal layer provides strength to the small intestine through a complex organization of collagen that forms a fibrous matrix. SIS material is obtained from the intestine in a manner that removes all cells, but leaves the naturally fibrous and porous nature of the matrix intact. The careful processing leaves the complex ECM available for new cell ingrowth.

Composition

The thin, yet strong, layer of the small intestine from which SIS products are derived possesses a 3-dimensional architecture that allows for intimate cell contact and consists primarily of protein. SIS products are manufactured using a unique process that minimizes the loss of the natural ECM components and structure.

Safety and biocompatibility

To assure patient safety, the SIS material undergoes a thorough disinfection, decellularization, and viral inactivation process. As a final step in the process, all SIS products are sterilized by validated sterilization methods.

SIS products have been rigorously tested in accordance with recognized biocompatibility standards.

Note References

Biochemistry

References noted with a yellow highlight refer to human patients.

Abed A, Deval B, Assoul N, Bataille I, Portes P, Louedec L, Henin D, Letourneur D, Meddahi-Pellé A. A biocompatible polysaccharide hydrogel-embedded polypropylene mesh for enhanced tissue integration in rats. Tissue Eng Part A. 2008;14:519-527.

Ahn HH, Kim KS, Lee JH, Lee MS, Song IB, Cho MH, Shin YN, Kim MS, Khang G, Lee HB. Porcine small intestinal submucosa sheets as a scaffold for human bone marrow stem cells. Int J Biol Macromol. 2007;41:590-596.

Almarza AJ, Yang G, Woo SL, Nguyen T, Abramowitch SD. Positive changes in bone marrow-derived cells in response to culture on an aligned bioscaffold. Tissue Eng. 2008;14:1489-1495.

Androjna C, Spragg RK, Derwin KA. Mechanical conditioning of cell-seeded small intestine submucosa: a potential tissue-engineering strategy for tendon repair. Tissue Eng. 2007;13:233-243.

Azzarello J, Ihnat MA, Kropp BP, Warnke LA, Lin HK. Assessment of angiogenic properties of biomaterials using the chicken embryo chorioallantoic membrane assay. Biomed Mater. 2007;2:55-61.

Badylak S, Liang A, Record R, Tullius R, Hodde J. Endothelial cell adherence to small intestinal submucosa: an acellular bioscaffold. Biomaterials. 1999;20:2257-2263.

Badylak SF, Grompe M, Caplan AI, Greisler HP, Guldberg RE, Taylor DA. In vivo remodeling breakout session summary. Ann N Y Acad Sci. 2002;961:319-322.

Badylak SF, Park K, Peppas N, McCabe G, Yoder M. Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix. Exper Hematol. 2001;29:1310-1318.

Badylak SF, Record R, Lindberg K, Hodde J, Park K. Small intestinal submucosa: a substrate for in vitro cell growth. J Biomater Sci Polym Ed. 1998;9:863-878.

Badylak SF. In vivo studies to evaluate tissue engineering techniques. Ann N Y Acad Sci. 2002;961:302-304.

Badylak SF. The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol. 2002;13:377-383.

Bara H, Sambanis A. Development and characterization of a tissue engineered pancreatic substitute based on recombinant intestinal endocrine L-cells. Biotechnol Bioeng. 2009;103:828-834.

Brennan EP, Reing J, Chew D, Myers-Irvin JM, Young EJ, Badylak SF. Antibacterial activity within degradation products of biological scaffolds composed of extracellular matrix. Tissue Eng. 2006;12:2949-2955.

Brightman AO, Rajwa BP, Sturgis JE, McCallister ME, Robinson JP, Voytik-Harbin SL. Time-lapse confocal reflection microscopy of collagen fibrillogenesis and extracellular matrix assembly in vitro. Biopolymers 2000;54:222-234.

Gilbert TW, Stewart-Akers AM, Badylak SF. A quantitative method for evaluating the degradation of biologic scaffold materials. Biomaterials. 2007;28:147-150.

Carbonell AM, Matthews BD, Dreau D, Foster M, Austin CE, Kercher KW, Sing RF, Heniford BT. The susceptibility of prosthetic biomaterials to infection. Surg Endosc. 2005;19:430-435.

Cen S, Li W, Huang F. [Preliminary research on construction of artificial esophagus with cultured squamous epithelial cells and myoblast cells seeded on small intestinal submucosa]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006;20:1040-1043.

Chen W, Li C, Wu S, Xie H, Luo J. [Effect of acellular process on small intestinal submucosa cell residue and growth factor content]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010;24:94-99.

Chun SY, Lim GJ, Kwon TG, Kwak EK, Kim BW, Atala A, Yoo JJ. Identification and characterization of bioactive factors in bladder submucosa matrix. Biomaterials. 2007;28:4251-4256.

de Paula M, Goissis G, Martins VC, da Silva Trindade JC. Injectable gels of anionic collagen: rhamsan composites for plastic correction: preparation, characterization, and rheological properties. J Biomed Mater Res B Appl Biomater. 2005;75:393-399.

Wilshaw SP, Burke D, Fisher J, Ingham E. Investigation of the antiadhesive properties of human mesothelial cells cultured in vitro on implantable surgical materials. J Biomed Mater Res B Appl Biomater. 2009;88:49-60.

Dozmorov MG, Kyker KD, Saban R, Knowlton N, Dozmorov I, Centola MB, Hurst RE. Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells. BMC Cancer. 2006;6:12.

Badylak SF, Valentin JE, Ravindra AK, McCabe GP, Stewart-Akers AM. Macrophage phenotype as a determinant of biologic scaffold remodeling. Tissue Eng Part A. 2008;14:1835-1842.

Elkin M, Miao HQ, Nagler A, Aingorn E, Reich R, Hemo I, Dou HL, Pines M, Vlodavsky I. Halofuginone: a potent inhibitor of critical steps in angiogenesis progression. FASEB J. 2000;14:2477-2485.

Fan MR, Gong M, Da LC, Bai L, Li XQ, Chen KF, Li-Ling J, Yang ZM, Xie HQ. Tissue engineered esophagus scaffold constructed with porcine small intestinal submucosa and synthetic polymers. Biomed Mater. 2014;9:015012.

Fan WJ, Yang ZM, Li XQ, Wang Z, Zhi W, Qiu L. [The experiment of porcine keratinocytes cultured on porcine small intestinal submucosa in vitro]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2006;22:220-222.

Feil G, Christ-Adler M, Maurer S, Corvin S, Rennekampff HO, Krug J, Hennenlotter J, Kuehs U, Stenzl A, Sievert KD. Investigations of urothelial cells seeded on commercially available small intestine submucosa. Eur Urol. 2006;50:1330-1337.

Yue TW, Chien WC, Tseng SJ, Tang SC. EDC/NHS-mediated heparinization of small intestinal submucosa for recombinant adeno-associated virus serotype 2 binding and transduction. Biomaterials. 2007;28:2350-2357.

Freytes DO, Martin J, Velankar SS, Lee AS, Badylak SF. Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix. Biomaterials. 2008;29:1630-1637.

Gilbert TW, Freund JM, Badylak SF. Quantification of DNA in biologic scaffold materials. J Surg Res. 2009;152:135-139.

Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials. 2006;27:3675-3683.

Gilbert TW, Stewart-Akers AM, Sydeski J, Nguyen TD, Badylak SF, Woo SL. Gene expression by fibroblasts seeded on small intestinal submucosa and subjected to cyclic stretching. Tissue Eng. 2007;13:1313-1323.

Grimes M, Pembroke JT, McGloughlin T. The effect of choice of sterilisation method on the biocompatibility and biodegradability of SIS (small intestinal submucosa). Biomed Mater Eng 2005;15:65-71.

Han BS, Fan CY, Liu SH. [Improvement of blood compatibility of small intestinal submucosa used as engineering vascular scaffolds by nano-bionic surface modification.] Zhonghua Yi Xue Za Zhi 2006;86:2065-2068.

Han P, Yang Z, Zhi W. [Experimental studies on canine bladder smooth muscle cells cultured on acellular small intestinal submucosa in vitro]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007;21:1366-1370.

Hauser PJ, Han Z, Sindhwani P, Hurst RE. Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Anticancer Res. 2007;27:737-740.

Hodde J, Janis A, Hiles M. Effects of sterilization on an extracellular matrix scaffold: Part II. Bioactivity and matrix interaction. J Mater Sci Mater Med. 2007;18:545-550.

Hodde J, Record R, Badylak S. Assessment of angiogenesis in an in vitro three dimensional assay. Cardiac Vascular Regen. 2000;4:236-245.

Hodde J, Record R, Tullius R, Badylak S. Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix. Biomaterials. 2002;23:1841-1848.

Hodde JP, Badylak SF, Brightman AO, Voytik-Harbin SL. Glycosaminoglycan content of small intestinal submucosa: a bioscaffold for tissue replacement. Tissue Eng. 1996;2:209-217.

Hodde JP, Record RD, Liang HA, Badylak SF. Vascular endothelial growth factor in porcine-derived extracellular matrix. Endothelium. 2001;8:11-24.

Hodde JP, Hiles MC. Bioactive FGF-2 in sterilized extracellular matrix. Wounds. 2001;13:195-201.

Hodde JP, Record RD, Tullius RS, Badylak SF. Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization. Tissue Eng. 2002;8:225-234.

Hoganson DM, Owens GE, O'Doherty EM, Bowley CM, Goldman SM, Harilal DO, Neville CM, Kronengold RT, Vacanti JP. Preserved extracellular matrix components and retained biological activity in decellularized porcine mesothelium. Biomaterials. 2010;31:6934-6940.

Freytes DO, Tullius RS, Badylak SF. Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder. J Biomed Mater Res B Appl Biomater. 2006;78:327-333.

Holtom PD, Shinar Z, Benna J, Patzakis MJ. Porcine small intestine submucosa does not show antimicrobial properties. Clin Orthop. 2004;427:18-21.

Hou J, Xiang HL, Feng XS, Tian XH, Pang XL, Teng Y. [Co-culture of cryopreserved rat islets with small intestinal submucosa]. Nan Fang Yi Ke Da Xue Xue Bao. 2006;26:1121-1123.

Hurst RE, Bonner RB. Mapping of the distribution of significant proteins and proteoglycans in small intestinal submucosa by fluorescence microscopy. J Biomater Sci Polym Ed. 2001;12:1267-1279.

Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA. A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel. Cancer Lett. 2005;217:171-180.

Hurst RE, Kyker KD, Bonner RB, Bowditch RD, Hemstreet GP 3rd. Matrix-dependent plasticity of the malignant phenotype of bladder cancer cells. Anticancer Res. 2003;23:3119-3128.

Hurst RE, Kyker KD, Dozmorov MG, Takemori N, Singh A, Matsumoto H, Saban R, Betgovargez E, Simonian MH. Proteome-level display by 2-dimensional chromatography of extracellular matrix-dependent modulation of the phenotype of bladder cancer cells. Proteome Sci. 2006;4:13.

Hyun H, Lee JH, Seo KS, Kim MS, Rhee JM, Lee HB, Khang G. [The release of albumin from PLGA and PCL wafers containing natural and synthetic additives for protein delivery]. Polymer Korea. 2005;29:468-474.

Mondalek FG, Lawrence BJ, Kropp BP, Grady BP, Fung KM, Madihally SV, Lin HK. The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials. Biomaterials. 2008;29:1159-1166.

Jiang T, Wang G, Qiu J, Luo L, Zhang G. Heparinized poly(vinyl alcohol)-small intestinal submucosa composite membrane for coronary covered stents. Biomed. Mater. 2009;4:025012.

Johnston DE, Boughner DR, Cimini M, Rogers KA. Radial artery as an autologous cell source for valvular tissue engineering efforts. J Biomed Mater Res A. 2006;78:383-393.

Kasyanov VA, Hodde J, Hiles MC, Eisenberg C, Eisenberg L, De Castro LE, Ozolanta I, Murovska M, Draughn RA, Prestwich GD, Markwald RR, Mironov V. Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized natural scaffold with laser-machined micropores. J Mat Sci Mater Med. 2009;20:329-337.

Kim MS, Seo KS, Hyun H, Kim SK, Khang G, Lee HB. Sustained release of bovine serum albumin using implantable wafers prepared by MPEG-PLGA diblock copolymers. Int J Pharm. 2005;304:165-177.

Knowlton N, Dozmorov I, Kyker KD, Saban R, Cadwell C, Centola MB, Hurst RE. Template-driven gene selection procedure. IEEE Proceedings. Syst Biol (Stevenage). 2006;153:4-12.

Kyker KD, Culkin DJ, Hurst RE. A model for 3-dimensional growth of bladder cancers to investigate cell-matrix interactions. Urol Oncol. 2003;21:255-261.

Lakey JR, Woods EJ, Zieger MA, Avila JG, Geary WA, Voytik-Harbin SL, Critser JK. Improved islet survival and in vitro function using solubilized small intestinal submucosa. Cell Tissue Bank. 2001;2:217-224.

Lakshmanan Y, Frimberger D, Gearhart JD, Gearhart JP. Human embryoid body-derived stem cells in co-culture with bladder smooth muscle and urothelium. Urology 2005;65:821-826.

Lee SJ, Lee IW, Lee YM, Lee HB, Khang G. Macroporous biodegradable natural/synthetic hybrid scaffolds as small intestine submucosa impregnated poly(D,L-lactide-co-glycolide) for tissue-engineered bone. J Biomater Sci Polym Ed. 2004;15:1003-1017.

Li F, Li W, Johnson S, Ingram D, Yoder M, Badylak S. Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cells. Endothelium. 2004;11:199-206.

Lin P, Chan WC, Badylak SF, Bhatia SN. Assessing porcine liver-derived biomatrix for hepatic tissue engineering. Tissue Eng. 2004;10:1046-1053.

Lindberg K, Badylak SF. Porcine small intestinal submucosa (SIS): a bioscaffold supporting in vitro primary human epidermal cell differentiation and synthesis of basement membrane proteins. Burns. 2001;27:254-266.

Long RA, Nagatomi J, Chancellor MB, Sacks MS. The role of MMP-I up-regulation in the increased compliance in muscle-derived stem cell-seeded small intestinal submucosa. Biomaterials. 2006;27:2398-2404.

Li H, Ji T, Xu LQ, Hu YJ, Li SY, Zhang CP. [Study on the osteogenesis ability of co-culturing bone marrow stromal cells (BMSCs) and small intestinal submucosa]. Shanghai Kou Qiang Yi Xue. 2006;15:167-171.

Lu SH, Cannon TW, Chermanski C, Pruchnic R, Somogyi G, Sacks M, de Groat WC, Huard J, Chancellor MB. Muscle-derived stem cells seeded into acellular scaffolds develop calcium-dependent contractile activity that is modulated by nicotine receptors. Urology. 2003;61:1285-1291.

Lu SH, Sacks MS, Chung SY, Gloeckner DC, Pruchnic R, Huard J, de Groat WC, Chancellor MB. Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitution. Biomaterials. 2005;26:443-449.

Luo J, Yang Z, Li X, Deng L. [Cellular compatibility of small intestinal submucosa in vitro]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004;21:800-804.

Luo JC, Yang ZM [Preparation and characteristics of small intestinal submucosa]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003;17:425-428.

McDevitt CA, Wildey GM, Cutrone RM. Transforming growth factor-beta1 in a sterilized tissue derived from the pig small intestine submucosa. J Biomed Mater Res A. 2003;67:637-640.

McPherson TB, Badylak SF. Characterization of fibronectin derived from porcine small intestinal submucosa. Tissue Eng. 1998;4:75-83.

Mondalek FG, Zhang YY, Kropp B, Kopke RD, Ge X, Jackson RL, Dormer KJ. The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field. J Nanobiotechnology. 2006;4:4.

Hodde J, Janis A, Ernst D, Zopf D, Sherman D, Johnson C. Effects of sterilization on an extracellular matrix scaffold: part I. Composition and matrix architecture. J Mater Sci Mater Med. 2007;18:537-543.

Nguyen TD, Liang R, Woo SL, Burton SD, Wu C, Almarza A, Sacks MS, Abramowitch S. Effects of cell seeding and cyclic stretch on the fiber remodeling in an extracellular matrix-derived bioscaffold. Tissue Eng. 2009;15:957-963.

Nihsen ES, Johnson CE, Hiles MC. Bioactivity of small intestinal submucosa and oxidized regenerated cellulose/collagen. Adv Skin Wound Care. 2008;21:479-486.

Ninan L, Stroshine RL, Wilker JJ, Shi R. Adhesive strength and curing rate of marine mussel protein extracts on porcine small intestinal submucosa. Acta Biomater. 2007;3:687-694.

Ong SY, Dai H, Leong KW. Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture. Biomaterials. 2006;27:4087-4097.

Pariente JL, Kim BS, Atala A. In vitro biocompatibility evaluation of naturally derived and synthetic biomaterials using normal human bladder smooth muscle cells. J Urol. 2002;167:1867-1871.

Pariente JL, Kim BS, Atala A. In vitro biocompatibility assessment of naturally derived and synthetic biomaterials using normal human urothelial cells. J Biomed Mater Res. 2001;55:33-39.

Park KS, Jin CM, Yun SJ, Hong KD, Kim SH, Kim MS, Rhee JM, Khang G, Lee HB. [Effects of SIS sponge and bone marrow-derived stem cells on the osteogenic differentiation for tissue engineered bone]. Polymer Korea. 2005;29:501-507.

Perla V, Webster TJ. Nano-hydroxyapatite-thermally denatured small intestine sub-mucosa composites for entheses applications. Int J Nanomedicine. 2006;1:351-359.

Kasyanov V, Isenburg J, Draughn RA, Hazard S, Hodde J, Ozolanta I, Murovska M, Halkes SB, Vrasidas I, Liskamp RM, Pieters RJ, Simionescu D, Markwald RR, Mironov V. Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials. 2006;27:745-751.

Rauth TP, Poulose BK, Davidson JM, Nanney LB, Holzman MD. Mechanical abrasion improves early incorporation of small intestinal submucosa. Am Surg. 2007;73:647-651.

Record RD, Hillegonds D, Simmons C, Tullius R, Rickey FA, Elmore D, Badylak SF. In vivo degradation of 14C-labeled small intestinal submucosa (SIS) when used for urinary bladder repair. Biomaterials. 2001;22:2653-2659.

Reing JE, Zhang L, Myers-Irvin J, Cordero KE, Freytes DO, Heber-Katz E, Bedelbaeva K, McIntosh D, Dewilde A, Braunhut SJ, Badylak SF. Degradation products of extracellular matrix affect cell migration and proliferation. Tissue Eng Part A. 2009;15:605-614.

Rickey FA, Elmore D, Hillegonds D, Badylak S, Record R, Simmons-Byrd A.“Regeneration of tissue about an animal-based scaffold: AMS studies of the fate of the scaffold.” Nuclear Instruments and Methods in Physics Research 2000;172:904-909.

Rosenthal EL, Wax MK, Anderson P, Kulecz-Martin M.“The mucosal invasion model: A novel in vitro model for evaluating the invasive behavior of mucocutaneous malignancies.” Archives of Otolaryngology--Head & Neck Surgery 2001;127:1467-1470.

Sarikaya A, Record R, Wu CC, Tullius B, Badylak S, Ladisch M.“Antimicrobial activity associated with extracellular matrices.” Tissue Engineering 2002;8:63-71.

Schaaf A, McNealy T, Steidler A, Alken P, Michel MS.“[A new ex-vivo 3D bladder matrix model for standardised evaluation of urothelial transfection methods].” Aktuelle Urologie 2003;34:172-175.

Seddighi MR, Griffon DJ, Constable PD, Martin-Jimenez T.“Effects of porcine small intestinal submucosa on elution characteristics of gentamicin-impregnated plaster of Paris.” American Journal of Veterinary Research 2007;68:171-177.

Sellaro TL, Ravindra AK, Stolz DB, Badylak SF.“Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds.” Tissue Engineering 2007;13:2301-2310.

Shin HW, Kim SH, Jang JW, Kim MS, Cho SH, Lee HB, Khang G.“[Preparation and characterization of sponge using porcine small intestinal submucosa].” Polymer Korea 2004;28:194-200.

Su Y, Zeng BF, Zhang CQ, Zhang KG, Xie XT.“Study of biocompatibility of small intestinal submucosa (SIS) with Schwann cells in vitro.” Brain Research 2007;1145:41-47.

Suckow MA, Hall P, Wolter W, Sailes V, Hiles MC.“Use of an extracellular matrix material as a vaccine carrier and adjuvant.” Anticancer Research 2008;28:2529-2534.

Suckow MA, Wolter WR, Sailes VT.“Inhibition of prostate cancer metastasis by administration of a tissue vaccine.” Clinical and Experimental Metastasis 2008 Sept 28 [Epub]

Tan MY, Zhi W, Wei RQ, Huang YC, Zhou KP, Tan B, Deng L, Luo JC, Li XQ, Xie HQ, Yang ZM.“Repair of infarcted myocardium using mesenchymal stem cell seeded small intestinal submucosa in rabbits.” Biomaterials 2009;30:3234-3240.

Tian XH, Xue WJ, Ding XM, Pang XL, Teng Y, Tian PX, Feng XS.“Small intestinal submucosa improves islet survival and function during in vitro culture.” World Journal of Gastroenterology 2005;11:7378-7383.

Tian XH, Xue WJ, Pang XL, Teng Y, Tian PX, Feng XS.“Effect of small intestinal submucosa on islet recovery and function in vitro culture.” Hepatobiliary & pancreatic diseases international 2005;4:524-529.

Voytik-Harbin SL, Brightman AO, Kraine MR, Waisner B, Badylak SF.“Identification of extractable growth factors from small intestinal submucosa.” Journal of Cellular Biochemistry 1997;67:478-491.

Voytik-Harbin SL, Brightman AO, Waisner B, Lamar CH, Badylak SF.“Application and evaluation of the alamarBlue assay for cell growth and survival of fibroblasts.” In Vitro Cellular and Development Biology - Animal 1998;34:239-246.

Voytik-Harbin SL, Brightman AO, Waisner BZ, Robinson JP, Lamar CH.“Small intestinal submucosa: A tissue-derived extracellular matrix that promotes tissue-specific growth and differentiation of cells in vitro.” Tissue Engineering 1998;4:157-174.

Voytik-Harbin SL.“Three-dimensional extracellular matrix substrates for cell culture.” Methods in Cell Biology 2001;63:561-581.

Voytik-Harbin, SL, Rajwa B, Robinson JP.“Three-dimensional imaging of extracellular matrix and extracellular matrix-cell interactions.” Methods in Cell Biology 2001;63:583-597.

Wallis MC, Yeger H, Cartwright L, Shou Z, Radisic M, Haig J, Suoub M, Antoon R, Farhat WA.“Feasibility study of a novel urinary bladder bioreactor.” Tissue Engineering 2008:14:339-348.

Ware MH, Buckley CA.“The study of a light-activated albumin protein solder to bond layers of porcine small intestinal submucosa” Biomedical Science Instrumentation 2003;39:1-5.

Wolf MT, Daly KA, Reing JE, Badylak SF.“Biologic scaffold composed of skeletal muscle extracellular matrix.” Biomaterials 2012;33:2916-2925.

Woods AM, Rodenberg EJ, Hiles MC, Pavalko FM.“Improved biocompatibility of small intestinal submucosa (SIS) following conditioning by human endothelial cells.” Biomaterials 2004;25:515-525.

Woods EJ, Walsh CM, Sidner RA, Zieger MA, Lakey JR, Ricordi C, Critser JK.“Improved in vitro function of islets using small intestinal submucosa.” Transplantation Proceedings 2004;36:1175-1177.

Woods EJ, Walsh CM, Sidner RA, Zieger MA, Mullin S, Lakey JR, Ricordi C, Critser JK.“Enhanced recovery of cryopreserved islets using SIS.” Transplantation Proceedings 2004;36:1139-1142.

Xiaohui T, Wujun X, Xiaoming D, Xinlu P, Yan T, Puxun T, Xinshun F.“Small intestinal submucosa improves islet survival and function in vitro culture.” Transplant Proceedings 2006;38:1552-1558.

Yaramov N, Sokolov M, Angelov K, Petrov B, Pavlov V.“Histologic and biomechanical evaluation of biologic meshes following colonization with pseudomonas aeruginosa.” Journal of Surgical Research 2012;175:e25-e42.

Yoon H, Kim G.“Micro/nanofibrous scaffolds electrospun from PCL and small intestinal submucosa.” Journal of Biomaterials Sciences Polymer Edition 2010;21:553-562.

Zhang KG, Zeng BF, Zhang CQ.“[Periosteum construction in vitro by small intestinal submucosa combined with bone marrow mesenchymal stem cell].” Zhonghua Wai Ke Za Zhi 2005;43:1594-1597.

Zhang Y, Kropp BP, Moore P, Cowan R, Furness PD, Kolligian ME, Frey P, Cheng EY.“Coculture of bladder urothelial and smooth muscle cells on small intestinal submucosa: potential applications for tissue engineering technology.” Journal of Urology 2000;164:928-935.

Cell Biology

References noted with a yellow highlight refer to human patients.

Abed A, Deval B, Assoul N, Bataille I, Portes P, Louedec L, Henin D, Letourneur D, Meddahi-Pellé A.“A biocompatible polysaccharide hydrogel-embedded polypropylene mesh for enhanced tissue integration in rats.” Tissue Engineering 2008;14:519-527.

Ahn HH, Kim KS, Lee JH, Lee MS, Song IB, Cho MH, Shin YN, Kim MS, Khang G, Lee HB.“Porcine small intestinal submucosa sheets as a scaffold for human bone marrow stem cells.” International Journal of Biological Macromolecules 2007;41:590-596.

Almarza AJ, Yang G, Woo SL, Nguyen T, Abramowitch SD.“Positive changes in bone marrow-derived cells in response to culture on an aligned bioscaffold.” Tissue Engineering 2008;14:1489-1495.

Androjna C, Spragg RK, Derwin KA“Mechanical conditioning of cell-seeded small intestine submucosa: A potential tissue-engineering strategy for tendon repair.” Tissue Engineering 2007;13:233-243.

Azzarello J, Ihnat MA, Kropp BP, Warnke LA, Lin HK.“Assessment of angiogenic properties of biomaterials using the chicken embryo chorioallantoic membrane assay.” Biomedical Materials 2007;2:55-61.

Badylak S, Liang A, Record R, Tullius R, Hodde J.“Endothelial cell adherence to small intestinal submucosa: An acellular bioscaffold.” Biomaterials 1999;20:2257-2263.

Badylak SF, Grompe M, Caplan AI, Greisler HP, Guldberg RE, Taylor DA.“In vivo remodeling breakout session summary.” Annals of the New York Academy of Sciences 2002;961:319-322.

Badylak SF, Park K, Peppas N, McCabe G, Yoder M.“Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix.” Experimental Hematology 2001;29:1310-1318.

Badylak SF, Record R, Lindberg K, Hodde J, Park K.“Small intestinal submucosa: a substrate for in vitro cell growth.” Journal of Biomaterials Sciences Polymer Edition 1998;9:863-877.

Badylak SF, Valentin JE, Ravindra AK, McCabe GP, Stewart-Akers AM.“Macrophage phenotype as a determinant of biologic scaffold remodeling.” Tissue Engineering Part A 2008;14:1835-1842.

Badylak SF.“In vivo studies to evaluate tissue engineering techniques.” Annals of the New York Academy of Sciences 2002;961:302-304.

Badylak SF.“The extracellular matrix as a scaffold for tissue reconstruction.” Seminars in Cellular & Developmental Biology 2002:13;377-383.

Bara H, Sambanis A.“Development and characterization of a tissue engineered pancreatic substitute based on recombinant intestinal endocrine L-cells.” Biotechnology and Bioengineering 2009;103:828-834.

Brightman AO, Rajwa BP, Sturgis JE, McCallister ME, Robinson JP, Voytik-Harbin SL.“Time-lapse confocal reflection microscopy of collagen fibrillogenesis and extracellular matrix assembly in vitro.” Biopolymers 2000;54:222-234.

Bryan N, Ashwin H, Smart N, Bayon Y, Scarborough N, Hunt JA.“The innate oxygen dependant immune pathway as a sensitive parameter to predict the performance of biological graft materials.” Biomaterials 2012;33:6380-6392.

Carbonell AM, Matthews BD, Dreau D, Foster M, Austin CE, Kercher KW, Sing RF, Heniford BT.“The susceptibility of prosthetic biomaterials to infection.” Surgical Endoscopy 2005;19:430-435.

Cen S, Li W, Huang F.“[Preliminary research on construction of artificial esophagus with cultured squamous epithelial cells and myoblast cells seeded on small intestinal submucosa].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006;20:1040-1043.

Chun SY, Lim GJ, Kwon TG, Kwak EK, Kim BW, Atala A, Yoo JJ.“Identification and characterization of bioactive factors in bladder submucosa matrix” Biomaterials 2007;28:4251-4256.

Crapo PM, Wang Y.“Small intestinal submucosa gel as a potential scaffolding material for cardiac tissue engineering.” Acta Biomaterialia 2010;6:2091-2096.

Davis NF, Callanan A, McGuire BB, Flood HD, McGloughlin TM.“Evaluation of viability and proliferative activity of human urothelial cells cultured onto xenogenic tissue-engineered extracellular matrices.” Urology 2011;77:1007.e1-7.

Davis NF, Coakley DN, Callanan A, Flood HD, McGloughlin TM.“Evaluation of xenogenic extracellular matrices as adjuvant scaffolds for the treatment of stress urinary incontinence.” International Urogynecology Journal 2013 Jun 29. [Epub]

Dozmorov MG, Kyker KD, Saban R, Knowlton N, Dozmorov I, Centola MB, Hurst RE.“Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells.” BMC Cancer 2006;6:12.

Elkin M, Miao HQ, Nagler A, Aingorn E, Reich R, Hemo I, Dou HL, Pines M Vlodavsky I“Halofuginone: a potent inhibitor of critical steps in angiogenesis progression.” FASEB Journal 2000;14:2477-2485.

Fan WJ, Yang ZM, Li XQ, Wang Z, Zhi W, Qiu L.“[The experiment of porcine keratinocytes cultured on porcine small intestinal submucosa in vitro].” Zhonghua Zheng Xing Wai Ke Za Zhi 2006;22:220-222.

Feil G, Christ-Adler M, Maurer S, Corvin S, Rennekampff HO, Krug J, Hennenlotter J, Kuehs U, Stenzl A, Sievert KD.“Investigations of urothelial cells seeded on commercially available small intestine submucosa.” European Urology 2006;50:1330-1337.

Freytes DO, Martin J, Velankar SS, Lee AS, Badylak SF.“Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix.” Biomaterials 2008;29:1630-1637.

Gilbert TW, Freund JM, Badylak SF.“Quantification of DNA in biologic scaffold materials.” Journal of Surgical Research 2009;152:135-139.

Gilbert TW, Stewart-Akers AM, Badylak SF.“A quantitative method for evaluating the degradation of biologic scaffold materials.” Biomaterials 2007;28:147-150.

Gilbert TW, Stewart-Akers AM, Sydeski J, Nguyen TD, Badylak SF, Woo SL.“Gene expression by fibroblasts seeded on small intestinal submucosa and subjected to cyclic stretching.” Tissue Engineering 2007;13:1313-1323.

Grant SA, Deeken CR, Hamilton SR, Grant DA, Bachman SL, Ramshaw BJ.“A comparative study of the remodeling and integration of a novel AuNP-tissue scaffold and commercial tissue scaffolds in a porcine model.” Journal of Biomaterials Materials Research A 2013 Feb 21. [Epub]

Gumina S, Patti AM, Vulcano A, Della Rocca C, Postacchini F.“Culture of human rotator cuff cells on orthobiologic support (porcine small intestinal submucosa).” Musculoskeletal surgery 2009;93 Suppl 1:S65-S70.

Han P, Yang Z, Zhi W.“[Experimental studies on canine bladder smooth muscle cells cultured on acellular small intestinal submucosa in vitro].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2007;21:1366-1370.

Hata H, Bär A, Dorfman S, Vukadinovic Z, Sawa Y, Haverich A, Hilfiker A.“Engineering a novel three-dimensional contractile myocardial patch with cell sheets and decellularised matrix.” European Journal of Cardiothoracic Surgery 2010;38:450-455.

Hauser PJ, Han Z, Sindhwani P, Hurst RE.“Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix.” Anticancer Research 2007;27:737-740.

Heise RL, Ivanova J, Parekh A, Sacks M.“Generating elastin-rich SIS-based smooth muscle constructs utilizing exogenous growth factors and cyclic mechanical stimulation.” Tissue Engineering Part A 2009;15:3951-3960.

Hodde J, Record R, Badylak S.“Assessment of angiogenesis in an in vitro three dimensional assay.” Cardiac and Vascular Regeneration 2000;4:236-245.

Hodde J, Record R, Tullius R, Badylak S.“Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix.” Biomaterials 2002;23:1841-1848.

Hodde JP, Badylak SF, Record RD.“Vascular endothelial growth factor in porcine-derived extracellular matrix.” Endothelium 2001;8:11-24.

Hodde JP, Hiles MC.“Bioactive FGF-2 in sterilized extracellular matrix.” Wounds 2001;13:195-201.

Hodde JP, Record RD, Tullius RS, Badylak SF.“Retention of endothelial cell adherence to porcine-derived extracellular matrix following disinfection and sterilization.” Tissue Engineering 2002;8:225-234.

Holtom PD, Shinar Z, Benna J, Patzakis MJ.“Porcine small intestine submucosa does not show antimicrobial properties.” Clinical Orthopaedics 2004;427:18-21.

Hoppensack A, Kazanecki CC, Colter D, Gosiewska A, Schanz J, Walles H, Schenke-Layland K.“A human in vitro model that mimics the renal proximal tubule.” Tissue Engineering Part C Methods 2013 Nov 24. [Epub]

Hou J, Xiang HL, Feng XS, Tian XH, Pang XL, Teng Y.“[Co-culture of cryopreserved rat islets with small intestinal submucosa].” Nan Fang Yi Ke Da Xue Xue Bao 2006;26:1121-1123.

Hurst RE, Hauser PJ, Kyker KD, Heinlen JE, Hodde JP, Hiles MC, Kosanke SD, Dozmorov M, Ihnat MA.“Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: A model for tumor cell "dormancy".” Plos One 2013;8:e64181.

Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA.“A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel.” Cancer Letters 2005;217:171-180.

Hurst RE, Kyker KD, Bonner RB, Bowditch RD, Hemstreet GP.“Matrix-dependent plasticity of the malignant phenotype of bladder cancer cells.” Anticancer Research 2003;23:3119-3128.

Hurst RE, Kyker KD, Dozmorov MG, Takemori N, Singh A, Matsumoto H, Saban R, Betgovargez E, Simonian MH.“Proteome-level display by 2-dimensional chromatography of extracellular matrix-dependent modulation of the phenotype of bladder cancer cells.” Proteome Science 2006;4:13.

Johnston DE, Boughner DR, Cimini M, Rogers KA.“Radial artery as an autologous cell source for valvular tissue engineering efforts.” Journal of Biomedical Materials Research 2006;78:383-393.

Jones CM, Hinds MT, Pavcnik D.“Retention of an autologous endothelial layer on a bioprosthetic valve for the treatment of chronic deep venous insufficiency.” Journal of Vascular and Interventional Radiology 2012;23:697-703.

Kang KN, Kim DY, Yoon SM, Kwon JS, Seo HW, Kim ES, Lee B, Kim JH, Min BH, Lee HB, Kim MS.“In vivo release of bovine serum albumin from an injectable small intestinal submucosa gel.” International Journal of Pharmaceutics 2011;420:266-273.

Kasyanov VA, Hodde J, Hiles MC, Eisenberg C, Eisenberg L, De Castro LE, Ozolanta I, Murovska M, Draughn RA, Prestwich GD, Markwald RR, Mironov V.“Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized natural scaffold with laser-machined micropores.” Journal of Materials Science: Materials in Medicine 2009;20:329-337.

Kim SH, Song JE, Lee D, Khang G.“Development of poly(lactide-co-glycolide) scaffold-impregnated small intestinal submucosa with pores that stimulate extracellular matrix production in disc regeneration.” Journal of Tissue Engineering and Regenerative Medicine 2012 Jun 11.[Epub]

Knowlton N, Dozmorov I, Kyker KD, Saban R, Cadwell C, Centola MB, Hurst RE.“Template-driven gene selection procedure.” IEEE Proceedings. Systems Biology. 2006;153:4-12.

Kong Q, Gao B, Xing R, Xiang Z, Yang Z, Luo J, Li X.“[Small intestine submucosa as a scaffold for cartilage reconstruction in vitro].” Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2011;28:521-525.

Kundu AK, Gelman J, Tyson DR.“Composite thin film and electrospun biomaterials for urologic tissue reconstruction.” Biotechnology and Bioengineering 2011;108:207-215.

Kyker KD, Culkin DJ, Hurst RE.“A model for 3-dimensional growth of bladder cancers to investigate cell-matrix interactions.” Urologic Oncology 2003;21:255-261.

Lakey JR, Woods EJ, Zieger MA, Avila JG, Geary WA, Voytik-Harbin SL, Critser JK.“Improved islet survival and in vitro function using solubilized small intestinal submucosa.” Cell and Tissue Banking 2001;2:217-224.

Lakshmanan Y, Frimberger D, Gearhart JD, Gearhart JP.“Human embryoid body-derived stem cells in co-culture with bladder smooth muscle and urothelium.” Urology 2005;65:821-826.

Lauto A.“Integration of extracellular matrix with chitosan adhesive film for sutureless tissue fixation.” Lasers in Surgery and Medicine 2009;41:366-371.

Li F, Li W, Johnson S, Ingram D, Yoder M, Badylak S.“Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cells.” Endothelium 2004;11:199-206.

Li H, Han ZX, Xu LQ, Zhang CP.“[Experimental study of tissue-engineered biological small intestinal submucosa, membrane employed in dental implant traction.]” Zhonghua Kou Qiang Yi Xue Za Zhi 2009;44:433-437.

Li H, Ji T, Xu LQ, Hu YJ, Li SY, Zhang CP.“[Study on the osteogenesis ability of co-culturing bone marrow stromal cells (BMSCs) and small intestinal submucosa.]” Shanghai Kou Qiang Yi Xue 2006;15:167-171.

Liang R, Fisher M, Yang G, Hall C, Woo SL.“Alpha gal 1, 3-transferase knock out does not alter the properties of porcine extracellular matrix bioscaffolds.” Acta Biomaterialia 2011;7:1719-1727.

Liao M, Ning L, Chen X, Li X, Luo J, Qin T.“[Strain-induced tenogenic differentiation of bone marrow mesenchymal stem cells].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2010;24:817-821.

Lin P, Chan WC, Badylak SF, Bhatia SN.“Assessing porcine liver-derived biomatrix for hepatic tissue engineering.” Tissue Engineering 2004;10:1046-1053.

Lindberg K, Badylak SF.“Porcine small intestinal submucosa (SIS): A bioscaffold supporting in vitro primary human epidermal cell differentiation and synthesis of basement membrane proteins.” Burns 2001;27:254-266.

Liu S, Zhang H, Zhang X, Lu W, Huang X, Xie H, Zhou J, Wang W, Zhang Y, Liu Y, Deng Z, Jin Y.“Synergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repair.” Tissue Engineering Part A 2011;17:725-739.

Long RA, Nagatomi J, Chancellor MB, Sacks MS.“The role of MMP-I up-regulation in the increased compliance in muscle-derived stem cell-seeded small intestinal submucosa.” Biomaterials 2006;27:2398-2404.

Lu SH, Cannon TW, Chermanski C, Pruchnic R, Somogyi G, Sacks M, de Groat WC, Huard J, Chancellor MB.“Muscle-derived stem cells seeded into acellular scaffolds develop calcium-dependent contractile activity that is modulated by nicotine receptors.” Urology 2003;61:1285-1291.

Lu SH, Sacks MS, Chung SY, Gloeckner DC, Pruchnic R, Huard J, De Groat WC, Chancellor MB.“Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitution.” Biomaterials 2005;26:443-449.

Luo J, Yang Z, Li X, Deng L.“[Cellular compatibility of small intestinal submucosa in vitro].” Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2004;21:800-804.

Mangera A, Bullock AJ, Roman S, Chapple CR, Macneil S.“Comparison of candidate scaffolds for tissue engineering for stress urinary incontinence and pelvic organ prolapse repair.” BJU International 2013;112:674-685.

McDevitt CA, Wildey GM, Cutrone RM.“Transforming growth factor-B1 in a sterilized tissue derived from the pig small intestine submucosa.” Journal of Biomedical Materials Research 2003;67A:637-640.

Metzner A, Stock UA, Iino K, Fischer G, Huemme T, Boldt J, Braesen JH, Bein B, Renner J, Cremer J, Lutter G.“Percutaneous pulmonary valve replacement: autologous tissue-engineered valved stents.” Cardiovascular Research 2010;88:453-461.

Moll C, Reboredo J, Schwarz T, Appelt A, Schürlein S, Walles H, Nietzer S.“Tissue engineering of a human 3D in vitro tumor test system.” Journal of Visualized Experiments 2013 Aug 6;(78).

Mondalek FG, Lawrence BJ, Kropp BP, Grady BP, Fung KM, Madihally SV, Lin HK.“The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials.” Biomaterials 2008;29:1159-1166.

Nguyen TD, Liang R, Woo SL, Burton SD, Wu C, Almarza A, Sacks MS, Abramowitch S.“Effects of cell seeding and cyclic stretch on the fiber remodeling in an extracellular matrix-derived bioscaffold.” Tissue Engineering 2009;15:957-963.

Nguyen TD, Liang R, Woo SL, Burton SD, Wu C, Almarza A, Sacks MS, Abramowitch S.“Effects of cell seeding and cyclic stretch on the fiber remodeling in an extracellular matrix-derived bioscaffold.” Tissue Engineering 2008 Sep 10. [Epub]

Nihsen ES, Johnson CE, Hiles MC.“Bioactivity of small intestinal submucosa and oxidized regenerated cellulose/collagen.” Advances in Skin and Wound Care 2008;21:479-486.

Ninan L, Stroshine RL, Wilker JJ, Shi R.“Adhesive strength and curing rate of marine mussel protein extracts on porcine small intestinal submucosa.” Acta Biomaterialia 2007;3:687-694.

Ong SY, Dai H, Leong KW.“Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture.” Biomaterials 2006;27:4087-4097.

Otto WR, Sarraf CE.“Culturing and differentiating human mesenchymal stem cells for biocompatible scaffolds in regenerative medicine.” Methods in Molecular Biology 2012;806:407-426.

Owen K, Wilshaw SP, Homer-Vanniasinkam S, Bojar RA, Berry H, Ingham E.“Assessment of the antimicrobial activity of acellular vascular grafts.” European Journal of Vascular and Endovascular Surgery 2012;43:573-581.

Pariente JL, Kim B-S, Atala A.“In vitro biocompatibility evaluation of naturally derived and synthetic biomaterials using normal human bladder smooth muscle cells.” Journal of Urology 2002;167:1867-1871.

Pariente JL, Kim BS, Atala A.“In vitro biocompatibility assessment of naturally derived and synthetic biomaterials using normal human urothelial cells.” Journal of Biomedical Materials Research 2001;55:33-39.

Park KS, Jin CM, Yun SJ, Hong KD, Kim SH, Kim MS, Rhee JM, Khang G, Lee HB.“[Effects of SIS sponge and bone marrow-derived stem cells on the osteogenic differentiation for tissue engineered bone].” Polymer Korea 2005;29:501-507.

Peng HF, Swartz D, Andreadis ST.“Hair follicle derived smooth muscle cells for engineering mechanically robust and vasoreactive vascular media.” Tissue Engineering Part A 2011;17:981-990.

Perla V, Webster TJ.“Nano-hydroxyapatite-thermally denatured small intestine sub-mucosa composites for entheses applications.” International Journal of Nanomedicine 2006;1:351-359.

Poghosyan T, Gajoux S, Vanneaux V, Bruneval P, Domet T, Lecourt S, Jarraya M, Sfeir R, Larghero J, Cattan P.“In vitro development and characterization of a tissue engineered conduit resembling esophageal wall using human and pig skeletal myoblast, oral epithelial cells and biologic scaffolds.” Tissue Engineering Part A 2013 May 14. [Epub]

Reing JE, Zhang L, Myers-Irvin J, Cordero KE, Freytes DO, Heber-Katz E, Bedelbaeva K, McIntosh D, Dewilde A, Braunhut SJ, Badylak SF.“Degradation products of extracellular matrix affect cell migration and proliferation.” Tissue Engineering 2009;15:605-614.

Rosenthal EL, Wax MK, Anderson P, Kulecz-Martin M.“The mucosal invasion model: A novel in vitro model for evaluating the invasive behavior of mucocutaneous malignancies.” Archives of Otolaryngology--Head & Neck Surgery 2001;127:1467-1470.

Rossetto VJ, da Mota LS, Rocha NS, Miot HA, Grandi F, Brandão CV.“Grafts of porcine small intestinal submucosa seeded with cultured homologous smooth muscle cells for bladder repair in dogs.” Acta Veterinaria Scandinavica 2013;55:39.

Roy Chowdhury R, Aachoui Y, Ghosh SK.“Effects of small intestinal submucosa (sis) on the murine innate immune microenvironment induced by heat-killed staphylococcus aureus.” PLOS One 2012;7(11):e48724.

Sarikaya A, Record R, Wu CC, Tullius B, Badylak S, Ladisch M.“Antimicrobial activity associated with extracellular matrices.” Tissue Engineering 2002;8:63-71.

Schaaf A, McNealy T, Steidler A, Alken P, Michel MS.“[A new ex-vivo 3D bladder matrix model for standardised evaluation of urothelial transfection methods].” Aktuelle Urologie 2003;34:172-175.

Sellaro T, Ranade A, Faulk D, McCabe GP, Dorko K, Badylak SF, Strom S.“Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels.” Tissue Engineering Part A 2010;16:1075-1082.

Sellaro TL, Ravindra AK, Stolz DB, Badylak SF.“Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds.” Tissue Engineering 2007;13:2301-2310.

Shea KP, McCarthy MB, Ledgard F, Arciero C, Chowaniec D, Mazzocca AD.“Human tendon cell response to 7 commercially available extracellular matrix materials: An in vitro study.” Arthroscopy 2010;26:1181-1188.

Su Y, Zeng BF, Zhang CQ, Zhang KG, Xie XT.“Study of biocompatibility of small intestinal submucosa (SIS) with Schwann cells in vitro.” Brain Research 2007;1145:41-47.

Suckow MA, Hall P, Wolter W, Sailes V, Hiles MC.“Use of an extracellular matrix material as a vaccine carrier and adjuvant.” Anticancer Research 2008;28:2529-2534.

Suckow MA, Wolter WR, Sailes VT.“Inhibition of prostate cancer metastasis by administration of a tissue vaccine.” Clinical and Experimental Metastasis 2008 Sept 28 [Epub]

Tan B, Wei RQ, Yang ZM, Li XQ, Han P, Zhi W, Xie HQ, Ren Y, Tan ZX.“[Experiment of oral mucosa epithelial cells cultured on small intestinal submucosa in vitro].” Hua Xi Kou Qiang Yi Xue Za Zhi 2010;28:76-80.

Tan HS, Fu WJ, Li JQ, Wang ZX, Li G, Ma X, Dong J, Gao JP, Wang XX, Zhang X.“[Construction of a capsular tissue-engineered ureteral stent seeded with autologous urothelial cells].” Nan Fang Yi Ke Da Xue Xue Bao 2013;33:48-52.

Tan MY, Zhi W, Wei RQ, Huang YC, Zhou KP, Tan B, Deng L, Luo JC, Li XQ, Xie HQ, Yang ZM.“Repair of infarcted myocardium using mesenchymal stem cell seeded small intestinal submucosa in rabbits.” Biomaterials 2009;30:3234-3240.

Tan Y, Zhang Y, Pei M.“Meniscus reconstruction through co-culturing meniscus cells with synovium-derived stem cells on small intestine submucosa - A pilot study to engineer meniscus tissue constructs.” Tissue Engineering Part A 2010;16:67-79.

Tian XH, Xue WJ, Ding XM, Pang XL, Teng Y, Tian PX, Feng XS.“Small intestinal submucosa improves islet survival and function during in vitro culture.” World Journal of Gastroenterology 2005;11:7378-7383.

Tian XH, Xue WJ, Pang XL, Teng Y, Tian PX, Feng XS.“Effect of small intestinal submucosa on islet recovery and function in vitro culture.” Hepatobiliary & pancreatic diseases international 2005;4:524-529.

Voytik-Harbin SL, Brightman AO, Kraine MR, Waisner B, Badylak SF.“Identification of extractable growth factors from small intestinal submucosa.” Journal of Cellular Biochemistry 1997;67:478-491.

Voytik-Harbin SL, Brightman AO, Waisner B, Lamar CH, Badylak SF.“Application and evaluation of the alamarBlue assay for cell growth and survival of fibroblasts.” In Vitro Cellular and Development Biology - Animal 1998;34:239-246.

Voytik-Harbin SL, Brightman AO, Waisner BZ, Robinson JP, Lamar CH.“Small intestinal submucosa: A tissue-derived extracellular matrix that promotes tissue-specific growth and differentiation of cells in vitro.” Tissue Engineering 1998;4:157-174.

Voytik-Harbin SL.“Three-dimensional extracellular matrix substrates for cell culture.” Methods in Cell Biology 2001;63:561-581.

Voytik-Harbin, SL, Rajwa B, Robinson JP.“Three-dimensional imaging of extracellular matrix and extracellular matrix-cell interactions.” Methods in Cell Biology 2001;63:583-597.

Vukadinovic-Nikolic Z, Andrée B, Dorfman SE, Pflaum M, Horvath T, Lux M, Venturini L, Bär A, Kensah G, Roa Lara A, Tudorache I, Cebotari S, Hilfiker-“Generation of bioartificial heart tissue by combining a 3D gel-based cardiac construct with decellularized small intestinal submucosa.” Tissue Engineering Part A 2013 Oct 9. [Epub]

Wallis MC, Yeger H, Cartwright L, Shou Z, Radisic M, Haig J, Suoub M, Antoon R, Farhat WA.“Feasibility study of a novel urinary bladder bioreactor.” Tissue Engineering 2008:14:339-348.

Wang JQ, Fan J, Gao JH, Zhang C, Bai SL.“Comparison of in vivo adipogenic capabilities of two different extracellular matrix microparticle scaffolds.” Plastic and Reconstructive Surgery 2013;131:174e-87e.

Wang Z, He Y, Yu X, Fu W, Wang W, Huang H.“Rapid vascularization of tissue-engineered vascular grafts in vivo by endothelial cells in co-culture with smooth muscle cells.” Journal of Materials Science Materials and Methods 2012;23:1109-1117.

Wilshaw SP, Burke D, Fisher J, Ingham E.“Investigation of the antiadhesive properties of human mesothelial cells cultured in vitro on implantable surgical materials.” Journal of Biomedical Materials Research Part B: Applied Biomaterials 2009;88B:49-60.

Woods AM, Rodenberg EJ, Hiles MC, Pavalko FM.“Improved biocompatibility of small intestinal submucosa (SIS) following conditioning by human endothelial cells.” Biomaterials 2004;25:515-525.

Woods EJ, Walsh CM, Sidner RA, Zieger MA, Lakey JR, Ricordi C, Critser JK.“Improved in vitro function of islets using small intestinal submucosa.” Transplantation Proceedings 2004;36:1175-1177.

Woods EJ, Walsh CM, Sidner RA, Zieger MA, Mullin S, Lakey JR, Ricordi C, Critser JK.“Enhanced recovery of cryopreserved islets using SIS.” Transplantation Proceedings 2004;36:1139-1142.

Wu S, Liu Y, Bharadwaj S, Atala A, Zhang Y.“Human urine-derived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering.” Biomaterials 2011;32:1317-1326.

Xiaohui T, Wujun X, Xiaoming D, Xinlu P, Yan T, Puxun T, Xinshun F.“Small intestinal submucosa improves islet survival and function in vitro culture.” Transplant Proceedings 2006;38:1552-1558.

Yang B, Zhou L, Sun Z, Yang R, Chen Y, Dai Y.“In vitro evaluation of the bioactive factors preserved in porcine small intestinal submucosa through cellular biological approaches.” Journal of Biomedical Materials Research 2010;93:1100-1109.

Yao C, Webster TJ, Hedrick M.“Decreased bacteria density on nanostructured polyurethane.” Journal of Biomedical Materials Research A 2013 Jun 19. [Epub]

Yeh HY, Lin TY, Lin CH, Yen BL, Tsai CL, Hsu SH.“Neocartilage formation from mesenchymal stem cells grown in type II collagen-hyaluronan composite scaffolds.” Differentiation 2014 Jan 23 [Epub]

Zhang H, Liu S, Zhou Y, Tan J, Che H, Ning F, Zhang X, Xun W, Huo N, Tang L, Deng Z, Jin Y.“Natural mineralized scaffolds promote the dentinogenic potential of dental pulp stem cells via the MAPK signaling pathway.” Tissue Engineering Part A 2012;18:677-691.

Zhang J, Zhi W, Tan M, Chen X, Li X, Deng L.“[An experimental study on rabbit bone marrow mesenchymal stem cells double-labeled by PKH26 and 5-bromo-2'-deoxyuriding in vitro and application in cardiac patch].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2010;24:828-33.

Zhang KG, Zeng BF, Zhang CQ.“[Periosteum construction in vitro by small intestinal submucosa combined with bone marrow mesenchymal stem cell].” Zhonghua Wai Ke Za Zhi 2005;43:1594-1597.

Zhang Y, Kropp BP, Moore P, Cowan R, Furness PD, Kolligian ME, Frey P, Cheng EY.“Coculture of bladder urothelial and smooth muscle cells on small intestinal submucosa: potential applications for tissue engineering technology.” Journal of Urology 2000;164:928-935.

Zhou Y, Yan Z, Zhang H, Lu W, Liu S, Huang X, Luo H, Jin Y.“Expansion and delivery of adipose-derived mesenchymal stem cells on three microcarriers for soft tissue regeneration.” Tissue Engineering Part A 2011;17:2981-2997.

Colorectal Surgery

References noted with a yellow highlight refer to human patients.

“The Surgisis AFP anal fistula plug: report of a consensus conference.” Colorectal Disease 2008;10:17-20.

A Ba-bai-ke-re MMTJ, Wen H, Huang HG, Chu H, Lu M, Chang ZS, Ai EHT, Fan K.“Randomized controlled trial of minimally invasive surgery using acellular dermal matrix for complex anorectal fistula.” World Journal of Gastroenterology 2010;16:3279-3286.

Adamina M, Hoch JS, Burnstein MJ.“To plug or not to plug: A cost-effectiveness analysis for complex anal fistula.” Surgery 2010;147:72-78.

Al-Sahaf O, El-Masry S.“The use of porcine small intestinal submucosa mesh (SURGISIS) as a pelvic sling in a man and a woman with previous pelvic surgery: two case reports.” Journal of Medical Case Reports 2009;3:70.

Amrani S, Zimmern A, O'Hara K, Corman ML.“The Surgisis AFP anal fistula plug.” Gastroenterologie Clinique et Biologique 2008;32:946-948.

Blom J, Husberg-Sellberg B, Lindelius A, Gustafsson UM, Carlens S, Oppelstrup H, Bragmark M, Yin L, Nyström PO.“Results of collagen plug occlusion of anal fistula: a multicentre study of 126 patients.” Colorectal Disease 2014 Feb 10. [Epub]

Boereboom CL, Watson NF, Sivakumar R, Hurst NG, Speake WJ.“Biological tissue graft for pelvic floor reconstruction after cylindrical abdominoperineal excision of the rectum and anal canal.” Techniques in Coloproctology 2009;13:257-258.

Borda Mederos LA, Chiroque Benites LI, Pinto Elera JO, Manzaneda Pineda AJ.“[Experience with a biological plug for biological in complex anal fistula].” Revista de gastroenterología del Perú 2011;31:345-350.

Borowiec AM, McCall M, Lees GM.“The trans-sphincteric posterior sagittal repair of recto-urinary and recto-vaginal fistulae using Surgisis mesh and fibrin sealant.” Techniques in Coloproctology 2012 Oct 25. [Epub]

Buchberg B, Masoomi H, Choi J, Bergman H, Mills S, Stamos MJ.“A tale of two (anal fistula) plugs: is there a difference in short-term outcomes?” American Surgeon 2010;76:1150-1153.

Champagne BJ, O'connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN.“Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up.” Diseases of the Colon and Rectum 2006;49:1817-1821.

Chan S, McCullough J, Schizas A, Vasas P, Engledow A, Windsor A, Williams A, Cohen CR.“Initial experience of treating anal fistula with the Surgisis anal fistula plug.” Techniques in Coloproctology 2012;16:201-206.

Cheung HYS, Wong JCH, Chung CC, Ng DCK, Ng LWC, Li MKW.“Anal fistula plug in the treatment of anal fistula: Local experience in Chinese patients.” Surgical Practice 2010;14:8-11.

Chew MH, Lee PJ, Koh CE, Chew HE.“Appraisal of the LIFT and BIOLIFT procedure: Initial experience and short-term outcomes of 33 consecutive patients.” International Journal of Colorectal Disease 2013 May 1. [Epub]

Christoforidis D, Etzioni DA, Goldberg SM, Madoff RD, Mellgren A.“Treatment of complex anal fistulas with the collagen fistula plug.” Diseases of the Colon and Rectum 2008;51:1482-1487.

Christoforidis D, Pieh MC, Madoff RD, Mellgren AF.“Treatment of transsphincteric anal fistulas by endorectal advancement flap or collagen fistula plug: a comparative study.” Diseases of the Colon and Rectum 2009;52:18-22.

Chung W, Kazemi P, Ko D, Sun C, Brown CJ, Raval M, Phang T.“Anal fistula plug and fibrin glue versus conventional treatment in repair of complex anal fistulas.” American Journal of Surgery 2009;197:604-608.

Chung W, Ko D, Sun C, Raval MJ, Brown CJ, Phang PT.“Outcomes of anal fistula surgery in patients with inflammatory bowel disease.” American Journal of Surgery 2010;199:609-613.

Cintron JR, Abcarian H, Chaudhry V, Singer M, Hunt S, Birnbaum E, Mutch MG, Fleshman J.“Treatment of fistula-in-ano using a porcine small intestinal submucosa anal fistula plug.” Techniques in Coloproctology 2013;17:187-191.

Cui JJ, Wang ZJ, Zheng Y, Han JG, Yang XQ.“[Ligation of the intersphincteric fistula tract plus bioprosthetic anal fistula plug (LIFT-plug) in the treatment of transsphincteric perianal fistula].” Zhonghua Wei Chang Wai Ke Za Zhi 2012;15:1232-1235.

Echenique I, Mella JR, Rosado F, Echenique IA, Mella MT, Quevedo G.“Puerto rico experience with plugs in the treatment of anal fistulas.” Boletin de la Asociacion Medica de Puerto Rico 2008;100:8-12.

El-Gazzaz G, Hull T, Mignanelli E, Hammel J, Gurland B, Zutshi M.“Analysis of function and predictors of failure in women undergoing repair of Crohn's related rectovaginal fistula.” Journal of Gastrointestinal Surgery 2010;14:824-829

El-Gazzaz G, Zutshi M, Hull T.“A retrospective review of chronic anal fistulaee treated by anal fistulae plug.” Colorectal Disease 2010;12:442-447.

Ellis CN, Rostas JW, Greiner FG.“Long-term outcomes with the use of bioprosthetic plugs for the management of complex anal fistulas.” Diseases of the Colon & Rectum 2010;53:798-802.

Ellis CN.“Short-term outcomes with the use of bioprosthetics for the management of parastomal hernias.” Diseases of the Colon and Rectum 2010;53:279-283.

Ellis CN.“Outcomes with the use of bioprosthetic grafts to reinforce the ligation of the intersphincteric fistula tract (BioLIFT procedure) for the management of complex anal fistulas.” Diseases of the Colon & Rectum 2010;53:1361-1364.

Ellis CN.“Outcomes after the repair of rectoceles with transperineal insertion of a bioprosthetic graft.” Diseases of the Colon and Rectum 2010;53:213-218.

Ellis CN.“Outcomes after repair of rectovaginal fistulas using bioprosthetics.” Diseases of the Colon & Rectum 2008;51:1084-1088.

Ellis CN.“Bioprosthetic plugs for complex anal fistulas: an early experience.” Journal of Surgical Education 2007;64:36-40.

Gaertner WB, Decanini A, Mellgren A, Lowry AC, Goldberg SM, Madoff RD, Spencer MP.“Does infliximab infusion impact results of operative treatment for Crohn's perianal fistulas?” Diseases of the Colon and Rectum 2007;50:1754-1760.

Gaertner WB, Madoff RD, Spencer MP, Mellgren A, Goldberg SM, Lowry AC.“Results of combined medical and surgical treatment of rectovaginal fistula in Crohn's disease.” Colorectal Disease 2011;13:678-683.

Gajsek U, McArthur DR, Sagar PM.“Long-term efficacy of the button fistula plug in the treatment of Ileal pouch-vaginal and Crohn's-related rectovaginal fistulas.” Diseases of the Colon and Rectum 2011;54:999-1002.

Garg P, Song J, Bhatia A, Kalia H, Menon GR.“The efficacy of anal fistula plug in fistula-in-ano: A systematic review.” Colorectal Disease 2010;12:965-970.

Garg P.“Flaps, glues, and plugs - A view from the East.” Seminars in Colon & Rectal Surgery 2009;20:52-57.

Garg P.“To determine the efficacy of anal fistula plug in the treatment of high fistula-in-ano- an initial experience.” Colorectal Disease 2009;11:588-591.

Garg P.“To determine the efficacy of anal fistula plug in the treatment of high fistula-in-ano- an initial experience.” Colorectal Disease 2008 Jul 15. [Epub]

Gonsalves S, Sagar P, Lengyel J, Morrison C, Dunham R.“Assessment of the efficacy of the rectovaginal button fistula plug for the treatment of ileal pouch-vaginal and rectovaginal fistulas.” Diseases of the Colon and Rectum 2009;52:1877-1881.

Greca FH, de Noronha L, Marcolini FR, Verona A, Pereira IA, Bier RS.“Small intestinal submucosa as a graft to increase rectum diameter.” Journal of Surgical Research 2013 Feb 20. [Epub]

Gubitosi A, Moccia G, Malinconico FA, Docimo G, Ruggiero R, Iside G, Avenia N,Docimo L, Foroni F, Gilio F, Sparavigna L, Agresti M.“[Trattamento conservativo delle fistole perianali con plug in matrice extracellulare biologica e colla di fibrina umana: esperienza preliminare.]” Il Giornal di Chirurgica 2009;30:46-50.

Gurland B, Garrett KA, Firoozi F, Goldman HB.“Transvaginal sacrospinous rectopexy: initial clinical experience.” Techniques in Coloproctology 2010;14:169-173.

Hadzhiev B.“Our first experience in treatment of ano rectal fistula with SURGISIS AFP Anal Fistula Plug.” Khirurgiia (Sofiia) 2011;:33-38.

Hoeppner J, Crnogorac V, Marjanovic G, Jüttner E, Keck T, Weiser HF, Hopt UT.“Small intestinal submucosa for reinforcement of colonic anastomosis.” International Journal of Colorectal Disease 2009;24:543-550.

Hyman N, O'Brien S, Osler T.“Outcomes after fistulotomy: results of a prospective, multicenter regional study.” Diseases of the Colon and Rectum 2009;52:2022-2027.

Itah R, White I, Greenberg R.“[Initial experience with collagen plug for the treatment of complex anal fistula]” Harefuah 2009;148:157-160, 211.

Kleif J, Hagen K, Wille-Jørgensen P.“Acceptable results using plug for the treatment of complex anal fistulas.” Danish Medical Bulletin 2011;58:A4254.

Ky AJ, Moore B, Fleshner P, Hucks RD, Hodde JP.“Treatment of Crohn's fistulae using an anal fistula plug of porcine small intestinal submucosa origin.” The Open Gastroentrology Journal 2012;6:25-30.

Ky AJ, Sylla P, Steinhagen R, Steinhagen E, Khaitov S, Ly EK.“Collagen fistula plug for the treatment of anal fistulas.” Diseases of the Colon and Rectum 2008;51:838-843.

Lawes DA, Efron JE, Abbas M, Heppell J, Young-Fadok TM.“Early experience with the bioabsorbable anal fistula plug.” World Journal of Surgery 2008;32:1157-1159.

Lenisa L, Espìn-Basany E, Rusconi A, Mascheroni L, Escoll-Rufino J, Lozoya-Trujillo R, Vallribera-Valls F, Mégevand J.“Anal fistula plug is a valid alternative option for the treatment of complex anal fistula in the long term.” International Journal of Colorectal Disease 2010;25:1487-1493.

Lupinacci RM, Vallet C, Parc Y, Chafai N, Tiret E.“Treatment of fistula-in-ano with the Surgisis® AFP anal fistula plug.” Gastroentérologie clinique et biologique 2010;34:549-553.

McGee MF, Champagne B.“Surgisis fistula plug: The United States experience.” Seminars in Colon & Rectal Surgery 2009;20:43-47.

McGee MF, Champagne BJ, Stulberg JJ, Reynolds H, Marderstein E, Delaney CP.“Tract length predicts successful closure with anal fistula plug in cryptoglandular fistulas.” Diseases of the Colon and Rectum 2010;53:1116-1120.

Mercer-Jones MA, D'Hoore A, Dixon AR, Lehur P, Lindsey I, Mellgren A, Stevenson AR.“Consensus on ventral rectopexy: report of a panel of experts.” Colorectal Disease 2014;16:82-88.

Miranda LE, Sabat BD, Carvalho EA.“A low-output colocutaneous fistula healed by Surgisis® anal plug.” Techniques in Coloproctology 2009;13:315-316.

Mirnezami AH, Gonsalves S, Gatt M, Sagar PM.“Ileal pouch-vaginal fistula: Treatment with the new Surgisis® Biodesign fistula plug.” Techniques in Coloproctology 2009;13:259-260.

Muhlmann MD, Hayes JL, Merrie AE, Parry BR, Bissett IP.“Complex anal fistulas: plug or flap?” ANZ Journal of Surgery 2011;81:720-724.

Ortiz H, Marzo J, Ciga MA, Oteiza F, Armendáriz P, de Miguel M.“Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula in ano.” British Journal of Surgery 2009;96:608-612.

Owen G, Keshava A, Stewart P, Patterson J, Chapuis P, Bokey E, Rickard M.“Plugs unplugged. Anal fistula plug: the Concord experience.” ANZ Journal of Surgery 2010;80:341-343.

Peacock O, Pandya H, Sharp T, Hurst NG, Speake WJ, Tierney GM, Lund JN.“Biological mesh reconstruction of perineal wounds following enhanced abdominoperineal excision of rectum (APER).” International Journal of Colorectal Disease 2012;27:475-482.

Powar M, Ogilvie J, Stevenson A.“Day-case laparoscopic ventral rectopexy: An achievable reality.” Colorectal Disease 2013 Jan 15. [Epub]

Rajaian S, Rajadoss MP, Nayak S, Kekre NS.“Traumatic rectourethral fistula repair: A potential application of porcine small intestinal submucosa.” Indian Journal of Urology 2013;29:148-150.

Rasmussen OØ.“[Anal fistula treated with collagen plug].” Ugeskrift for laeger 2007;10;169:4369.

Safar B, Jobanputra S, Sands D, Weiss EG, Nogueras JJ, Wexner SD.“Anal fistula plug: initial experience and outcomes.” Diseases of the Colon and Rectum 2009;52:248-252.

Schwandner O, Fuerst A, Herold A.“Anal fistula plug: A European perspective.” Seminars in Colon & Rectal Surgery 2009;20:48-51.

Schwandner O, Fuerst A, Kunstreich K, Scherer R.“Innovative technique for the closure of rectovaginal fistula using Surgisis mesh.” Techniques in Coloproctology 2009;13:135-140.

Schwandner O, Fuerst A.“Preliminary results on efficacy in closure of transsphincteric and rectovaginal fistulas associated with Crohn's disease using new biomaterials.” Surgical Innovation 2009;16:162-168.

Schwandner O, Stadler F, Dietl O, Wirsching RP, Fuerst A.“Initial experience on efficacy in closure of cryptoglandular and Crohn's transsphincteric fistulas by the use of the anal fistula plug.” International Journal of Colorectal Disease 2008;23:319-324.

Schwandner O.“Innovative management of anal fistula by the use of the anal fistula plug: Hype or help?” Minerva Chirurgica 2008;63:413-419.

Schwandner T, Roblick MH, Kierer W, Brom A, Padberg W, Hirschburger M.“Surgical treatment of complex anal fistulas with the anal fistula plug: A prospective, multicenter study.” Diseases of the Colon and Rectum 2009;52:1578-1583.

Tan KK, Kaur G, Byrne CM, Young CJ, Wright C, Solomon MJ.“Long-term outcome of the anal fistula plug for anal fistula of cryptoglandular origin.” Colorectal Disease 2013 Aug 25. [Epub]

Tan KK, Lee PJ.“Early experience of reinforcing the ligation of the intersphincteric fistula tract procedure with a bioprosthetic graft (BioLIFT) for anal fistula.” ANZ Journal of Surgery 2013 Jun 25. [Epub]

Thekkinkattil D, Botterill I, Ambrose S, Lundby L, Sagar P, Buntzen S, Finan P.“Efficacy of the anal fistula plug in complex anorectal fistulae.” Colorectal Disease 2009;11:584-587.

Thekkinkattil D, Botterill I, Ambrose S, Lundby L, Sagar P, Buntzen S, Finan P.“Efficacy of the anal fistula plug in complex anorectal fistulae.” Colorectal Disease 2008 July 15. [Epub]

van Koperen PJ, Bemelman WA, Bossuyt PM, Gerhards MF, Eijsbouts QA, van Tets WF, Janssen LW, Dijkstra FR, van Dalsen AD, Slors JF.“The anal fistula plug versus the mucosal advancement flap for the treatment of anorectal fistula (PLUG trial).” BMC Surgery 2008;8:11.

van Koperen PJ, Bemelman WA, Gerhards MF, Janssen LW, van Tets WF, van Dalsen AD, Slors JF.“The anal fistula plug treatment compared with the mucosal advancement flap for cryptoglandular high transsphincteric perianal fistula: a double-blinded multicenter randomized trial.” Diseases of the Colon and Rectum 2011;54:387-393.

van Koperen PJ, D'Hoore A, Wolthuis AM, Bemelman WA, Slors JF.“Anal fistula plug for closure of difficult anorectal fistula: A prospective study.” Diseases of the Colon and Rectum 2007;50:2168-2172.

Vaughan-Shaw PG, Cheung T, Knight JS, Nichols PH, Pilkington SA, Mirnezami AH.“A prospective case-control study of extralevator abdominoperineal excision (ELAPE) of the rectum versus conventional laparoscopic and open abdominoperineal excision: comparative analysis of short-term outcomes and quality of life.” Techniques in Coloproctology 2012;16:355-362.

Wang JY, Garcia-Aguilar J, Sternberg JA, Abel ME, Varma MG.“Treatment of transsphincteric anal fistulas: Are fistula plugs an acceptable alternative?” Diseases of the Colon and Rectum 2009;52:692-697.

Yaramov N, Sokolov M, Angelov K, Petrov B, Pavlov V.“[Surgical treatment of the perianal and rectovaginal fistulas by means of Surgisis AFP anal fistula plug].” Khirurgiia (Sofiia). 2010;4-5:10-13.

Zawadzki A, Starck M.“[Kollagenplugg - ny behandling av komplexa anala fistlar].” Lakartidningen 2008;105:1489-1491.

Zubaidi A, Al-Obeed O.“Anal fistula plug in high fistula-in-ano: An early Saudi experience.” Diseases of the Colon and Rectum 2009;52:1584-1588.

Zutshi M, Hull T, Gurland B.“Anal encirclement with sphincter repair (AESR procedure) using a biological graft for anal sphincter damage involving the entire circumference.” Colorectal Disease 2012;14:592-595.

Dental

References noted with a yellow highlight refer to human patients.

Kim DM, Nevins M, Camelo M, Schupbach P, Kim SW, Camelo JM, Al Hezaimi K, Nevins ML.“The feasibility of demineralized bone matrix and cancellous bone chips in conjunction with an extracellular matrix membrane for alveolar ridge preservation: a case series.” International Journal of Periodontics and Restorative Dentistry 2011;31:39-47.

Nevins M, Nevins ML, Camelo M, Camelo JM, Schupbach P, Kim DM.“The clinical efficacy of DynaMatrix Extracellular Membrane in augmenting keratinized tissue.” International Journal of Periodontics & Restorative Dentistry 2010;30:151-161.

Sommerlad S, Mackenzie D, Johansson C, Atwell R.“Guided bone augmentation around a titanium bone-anchored hearing aid implant in canine calvarium: An initial comparison of two barrier membranes.” Clinical Implant Dentistry and Related Research 2007;9:22-33.

Gastroenterology

References noted with a yellow highlight refer to human patients.

Ansaloni L, Bonasoni P, Cambrini P, Catena F, De Cataldis A, Gagliardi S, Gazzotti F, Peruzzi S, Santini D, Taffurelli M.“Experimental evaluation of Surgisis as scaffold for neointestine regeneration in a rat model.” Transplant Proceedings 2006;38:1844-1848.

Badylak S, Meurling S, Chen M, Spievack A, Simmons-Byrd A.“Resorbable bioscaffold for esophageal repair in a dog model.” Journal of Pediatric Surgery 2000;35:1097-1103.

Badylak SF, Hoppo T, Nieponice A, Gilbert TW, Davison JM, Jobe BA.“Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: A regenerative medicine approach with a biologic scaffold.” Tissue Engineering 2011;17:1643-1650.

Badylak SF, Vorp DA, Spievack AR, Simmons-Byrd A, Hanke J, Freytes DO, Thapa A, Gilbert TW, Nieponice A.“Esophageal reconstruction with ECM and muscle tissue in a dog model.” Journal of Surgical Research 2005;128:87-97.

Burugapalli K, Chan JC, Kelly JL, Pandit A.“Buttressing staples with cholecyst-derived extracellular matrix (cem) reinforces staple lines in an ex vivo peristaltic inflation model.” Obesity Surgery 2008;18:1418-1423.

Chen MK, Badylak SF“Small bowel tissue engineering using small intestinal submucosa as a scaffold.” Journal of Surgical Research 2001;99:352-358.

Chen MK, Beierle EA.“Animal models for intestinal tissue engineering.” Biomaterials 2004;25:1675-1681.

Choi JW, Park JK, Chang JW, Kim DY, Kim MS, Shin YS, Kim CH.“Small intestine submucosa and mesenchymal stem cells composite gel for scarless vocal fold regeneration. ” Biomaterials 2014 Mar 25 [Epub]

Choi JW, Park JK, Chang JW, Kim DY, Kim MS, Shin YS, Kim CH.“Small intestine submucosa and mesenchymal stem cells composite gel for scarless vocal fold regeneration. ” Biomaterials 2014 Mar 25 [Epub]

Clough A, Ball J, Smith GS, Leibman S.“Porcine small intestine submucosa matrix (Surgisis) for esophageal perforation.” Annals of Thoracic Surgery 2011;91:e15-6.

Darrien JH, Kasem H.“Successful closure of gastrocutaneous fistulas using the Surgisis® anal fistula plug.” Annals of the Royal College of Surgeons of England 2014; [E-pub]

Darrien JH, Kasem H.“Minimally invasive endoscopic therapy for the management of Boerhaave's syndrome.” Annals of the Royal College of Surgeons of England 2013;95:552-556.

de la Fuente SG, Gottfried MR, Lawson DC, Harris MB, Mantyh CR, Pappas TN“Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing.” Journal of Gastrointestinal Surgery 2003;7:96-101.

De Ugarte DA, Choi E, Weitzbuch H, Wulur I, Caulkins C, Wu B, Fonkalsrud EW, Atkinson JB, Dunn JC.“Mucosal regeneration of a duodenal defect using small intestine submucosa.” American Surgeon 2004;70:49-51.

Demirbilek S, Kanmaz T, Ozardali I, Edali MN, Yucesan S.“Using porcine small intestinal submucosa in intestinal regeneration.” Pediatric Surgery International 2003;19:588-592.

Diaz S, Brunt LM, Klingensmith ME, Frisella PM, Soper NJ.“Laparoscopic paraesophageal hernia repair, a challenging operation: medium-term outcome of 116 patients.” Journal of Gastroenterology 2003;7:59-67.

Doede T, Bondartschuk M, Joerck C, Schulze E, Goernig M.“Unsuccessful alloplastic esophageal replacement with porcine small intestinal submucosa.” Artificial Organs 2009;33:328-333.

Downey DM, Harre JG, Dolan JR.“Increased burst pressure in gastrointestinal staple-lines using reinforcement with a bioprosthetic material.” Obesity Surgery 2005;15:1379-1383.

Du XF, Kwon SK, Song JJ, Cho CG, Park SW.“Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits.” International Journal of Pediatric Otorhinolaryngology 2012;76:345-351.

el-Ghoul W“The effects of combined liquid and membrane barriers in prevention of post-operative intra-abdominal adhesions after experimental jejunal anastomosis in dogs.” Deutsche tierarztliche Wochenschrift. 2005;112:3-10.

Felsher J, Rosen M, Farres H, Walsh RM.“A novel endolaparoscopic intragastric partitioning for treatment of morbid obesity.” Surgical Laparoscopy, Endoscopy, and Percutaneous Techniques 2004;14:243-246.

Friedrich U, Vetter R, Klimas A, Reinsch S, Grosser K.“Oesophagusersatz mit einem Biodesign Surgisis (SIS)-Transplantat.” Chirurgische Allgemeine Zeitung 2013;4:259-262.

Fumagalli U, Rosati R, Caputo M, Bona S, Zago M, Lutmann F, Peracchia A.“Diaphragmatic acute massive herniation after laparoscopic gastroplasty for esophagectomy.” Diseases of the Esophagus 2006;19:40-43.

Gilbert TW, Agrawal V, Gilbert MR, Povirk KM, Badylak SF, Rosen CA.“Liver-derived extracellular matrix as a biologic scaffold for acute vocal fold repair in a canine model.” Laryngoscope 2009;119:1856-1863.

Goers TA, Cassera MA, Dunst CM, Swanstrom LL“Paraesophageal hernia repair with biomesh does not increase postoperative dysphagia. ” Journal of Gastrointestinal Surgery 2011;15-1743-1749.

Goers TA, Cassera MA, Dunst CM, Swanstrom LL“Paraesophageal hernia repair with biomesh does not increase postoperative dysphagia. ” Journal of Gastrointestinal Surgery 2011;15-1743-1749.

Gubbels SP, Richardson M, Trune D, Bascom DA, Wax MK.“Tracheal reconstruction with porcine small intestine submucosa in a rabbit model.” Otolaryngology and head and neck surgery 2006;134:1028-1035.

Hoeppner J, Crnogorac V, Marjanovic G, Jüttner E, Karcz W, Weiser HF, Hopt UT.“Small intestinal submucosa as a bioscaffold for tissue regeneration in defects of the colonic wall.” Journal of Gastrointestinal Surgery 2009;13:113-119.

Hoeppner J, Crnogorac V, Marjanovic G, Jüttner E, Karcz W, Weiser HF, Hopt UT.“Small intestinal submucosa as a bioscaffold for tissue regeneration in defects of the colonic wall.” Journal of Gastrointestinal Surgery 2008 Sep 3. [Epub]

Hoeppner J, Marjanovic G, Helwig P, Hopt UT, Keck T.“Extracellular matrices for gastrointestinal surgery: ex vivo testing and current applications.” World Journal of Gastroenterology 2010;16:4031-4038.

Hoeppner J, Wassmuth B, Marjanovic G, Timme S, Hopt UT, Keck T.“Anastomotic sealing by extracellular matrices (ECM) improves healing of colonic anastomoses in the critical early phase.” Journal of Gastrointestinal Surgery 2010;14:977-986.

Jacobs M, Gomez E; Plasencia G, Lopez-Penalver C, Lujan H, Velarde D, Jessee T.“Use of Surgisis mesh in laparoscopic repair of hiatal hernias.” Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 2007;17:365-368.

Jernigan TW, Croce MA, Cagiannos C, Shell DH, Handorf CR, Fabian TC.“Small intestinal submucosa for vascular reconstruction in the presence of gastrointestinal contamination.” Annals of Surgery 2004;239:733-740.

Johnson EK, Gaw JU, Armstrong DN.“Efficacy of anal fistula plug vs. fibrin glue in closure of anorectal fistulas.” Diseases of the Colon and Rectum 2006;49:371-376.

Jönsson L, Friberg LG, Gatzinsky V, Jennische E, Sandin A, Abrahamsson K.“Early regenerative response in the intrathoracic porcine esophagus - The impact of the inflammation.” Artificial Organs 2013 Dec 4. [E-Pub]

Jönsson L, Gatzinsky V, Jennische E, Johansson C, Nannmark U, Friberg LG.“Piglet model for studying esophageal regrowth after resection and interposition of a silicone stented small intestinal submucosa tube.” European Surgical Research 2011;46:169-179.

Kajitani M, Wadia Y, Xie H, Hinds MT, Shalaby SW, Swartz KR, Gregory KW.“Use of a new elastin patch and glue for repair of a major duodenal injury.” ASAIO Journal 2000;46:409-414.

Keckler SJ, St Peter SD, Calkins CM, Holcomb GW.“Occlusion of a recurrent tracheoesophageal fistula with Surgisis.” Journal of Laparoendoscopic and Advanced Surgical Techniques. Part A. 2008;18:465-468.

Kini S, Gagner M, de Csepel J, Gentileschi P, Dakin G.“A biodegradeable membrane from porcine intestinal submucosa to reinforce the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass: Preliminary report.” Obesity Surgery 2001;11:469-474.

Konstantinovic ML, Lagae P, Zheng F, Verbeken EK, De Ridder D, Deprest JA.“Comparison of host response to polypropylene and non-cross-linked porcine small intestine serosal-derived collagen implants in a rat model.” British Journal of Obstetrics and Gynecology 2005;112:1554-1560.

Lee M, Chang PC, Dunn JC.“Evaluation of small intestinal submucosa as scaffolds for intestinal tissue engineering.” Journal of Surgical Research 2008;147:168-171.

Lopes MF, Cabrita A, Ilharco J, Pessa P, Paiva-Carvalho J, Pires A, Patricio J.“Esophageal replacement in rat using porcine intestinal submucosa as a patch or a tube-shaped graft.” Diseases of the Esophagus 2006;19:254-259.

Lopes MF, Cabrita A, Ilharco J, Pessa P, Patricio J.“Grafts of porcine intestinal submucosa for repair of cervical and abdominal esophageal defects in the rat.” Journal of Investigative Surgery 2006;19:105-111.

Lyon JW, Hodde JP, Hucks D, Changkuon DI.“First experience with the use of a collagen fistula plug to treat enterocutaneous fistulas.” Journal of Vascular and Interventional Radiology 2013;24:1559-1565.

Maluf-Filho F, Hondo F, Halwan B, de Lima MS, Giordano-Nappi JH, Sakai P.“Endoscopic treatment of Roux-en-Y gastric bypass-related gastrocutaneous fistulas using a novel biomaterial.” Surgical Endoscopy 2009;23:1541-1545.

Marsh RE, Awad ZT, Cornet DA, Tomonaga T, Smyrk T, Filipi CJ.“Endoscopic SIS injection into the lower oesophageal sphincter in dogs.” Irish Journal of Medical Science 2003;172:20-23.

Martins MV, Skinovsky J, Chibata M.“[Bursting pressure comparison between stapler and staple line reinforcement with sutures and butress biologic material: an experimental study].” Arq Bras Cir Dig. 2013;26:80-83.

Nakatsu H, Ueno T, Oga A, Nakao M, Nishimura T, Kobayashi S, Oka M.“Influence of mesenchymal stem cells on stomach tissue engineering using small intestinal submucosa.” Journal of Tissue Engineering and Regenerative Medicine 2013 Aug 4. [Epub]

Nieponice A, Ciotola FF, Nachman F, Jobe BA, Hoppo T, Londono R, Badylak S, Badaloni AE.“Patch esophagoplasty: Esophageal reconstruction using biologic scaffolds.” Annals of Thoracic Surgery 2013 Nov 20. [Epub]

Nieponice A, Gilbert TW, Badylak SF.“Reinforcement of esophageal anastomoses with an extracellular matrix scaffold in a canine model.” Annals of Thoracic Surgery 2006;82:2050-2058.

Nieponice A, McGrath K, Qureshi I, Beckman EJ, Luketich JD, Gilbert TW, Badylak SF.“An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR.” Gastrointestinal Endoscopy 2009;69:289-296.

Nieponice A, McGrath K, Qureshi I, Beckman EJ, Luketich JD, Gilbert TW, Badylak SF.“An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR.” Gastrointestinal Endoscopy 2008 Jul 25. [Epub]

Nishimura T, Ueno T, Nakatsu H, Oga A, Kobayashi S, Oka M.“In vivo motility evaluation of the grafted gastric wall with small intestinal submucosa (SIS).” Tissue Engineering Part A 2010;16:1761-1768.

O'Connor L, Champagne BJ, Ferguson MA, Orangio GR, Schertzer ME, Armstrong DN.“Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas.” Diseases of the Colon and Rectum 2006;49:1569-1573.

Ong ES, Helton WS, Jho D, Espat NJ.“Surgisis-assisted surgical site control in the delayed repair of a complex bile duct injury after laparoscopic cholecystectomy.” Journal of Gastrointestinal Surgery 2006;10:202-206.

Pinheiro JS, Correa JL, Cohen RV, Novaes JA, Schiavon CA.“Staple line reinforcement with new biomaterial increased burst strength pressure: An animal study.” Surgery for Obesity and Related Diseases. 2006;2:397-399.

Pye PK, Dada T, Duthie G, Phillips K.“Surgisis mesh: a novel approach to repair of a recurrent rectovaginal fistula.” Diseases of the Colon and Rectum 2004;47:1554-1556.

Qin HH, Dunn JC.“Small intestinal submucosa seeded with intestinal smooth muscle cells in a rodent jejunal interposition model.” Journal of Surgical Research 2011;171:e21-e26.

Rajan E, Gostout C, Feitoza A, Herman L, Knipschield M, Burgart L, Chung S, Cotton P, Hawes R, Kalloo A, Kantsevoy S, Pasricha P.“Widespread endoscopic mucosal resection of the esophagus with strategies for stricture prevention: a preclinical study.” Endoscopy 2005;37:1111-1115.

Ringel RL, Kahane JC, Hillsamer PJ, Lee AS, Badylak SF.“The application of tissue engineering procedures to repair the larynx.” Journal of Speech, Language, and Hearing Research 2006;49:194-208.

Rosen M, Ponsky J, Petras R, Fanning A, Brody F, Duperior F.“Small intestinal submucosa as a bioscaffold for biliary tract regeneration.” Surgery 2002;132:480-486.

Satya R, Satya RJ.“Successful treatment of an enterocutaneous fistula with an anal fistula plug after an abdominal stab wound.” Journal of Vascular and Interventional Radiology 2010;21:414-415.

Schomisch SJ, Yu L, Wu Y, Pauli EM, Cipriano C, Chak A, Lash RH, Ponsky JL, Marks JM.“Commercially available biological mesh does not prevent stricture after esophageal mucosectomy.” Endoscopy 2014;46:144-148.

Schultz DJ, Brasel KJ, Spinelli KS, Rasmussen J, Weigelt JA.“Porcine small intestine submucosa as a treatment for enterocutaneous fistulas.” Journal of the American College of Surgeons 2002;194:541-543.

Smith AM, Walsh RM, Henderson JM.“Novel bile duct repair for bleeding biliary anastomotic varices: case report and literature review.” Journal of Gastrointestinal Surgery 2005;9:832-836.

Souza Filho ZA, Greca FH, Rocha SL, Ioshii SO, Domanski AC, Kfouri D, Campos PD, Silva RF.“[Porcine submucosa graft for the treatment of duodenal injuries in dogs].” Acta Chirgica Brasiliera 2005;20:394-398.

Souza Filho ZA, Ioshii SO, Greca FH, Lourdes Pessole Biondo-Simoes M, Rocha SL, Duda JR, Oliveira Filho HR“[Small intestine submucosa for repair of cervical esophageal lesions in a dog model].” Acta Cirurgica Brasileira 2003;18:224-231.

Tan B, Wang M, Chen X, Hou J, Chen X, Wang Y, Li-Ling J, Xie H.“Tissue engineered esophagus by copper-small intestinal submucosa graft for esophageal repair in a canine model.” Science China. Life Sciences. 2014 Jan 17. [Epub]

Tan B, Wei RQ, Tan MY, Luo JC, Deng L, Chen XH, Hou JL, Li XQ, Yang ZM, Xie HQ.“Tissue engineered esophagus by mesenchymal stem cell seeding for esophageal repair in a canine model.” Journal of Surgical Research 2012 Aug 17. [Epub]

Toussaint E, Eisendrath P, Kwan V, Dugardeyn S, Devière J, Le Moine O.“Endoscopic treatment of postoperative enterocutaneous fistulas after bariatric surgery with the use of a fistula plug: report of five cases.” Endoscopy 2009;41:560-563.

Tringali A, Daniel FB, Familiari P, Perri V, Mutignani M, Vitelli CE, Costamagna G.“Endoscopic treatment of a recalcitrant esophageal fistula with new tools: stents, Surgisis, and nitinol staples.” Gastrointestinal Endoscopy 2010;72:647-650.

Turner BG, Cizginer S, Kim MC, Mino-Kenudson M, Ducharme RW, Surti VC, Sylla P, Brugge WR, Rattner DW, Gee DW.“Stent placement provides safe esophageal closure in thoracic NOTES procedures.” Surgical Endoscopy 2011;25:913-918.

Ueno T, de la Fuente SG, Abdel-Wahab OI, Takahashi T, Gottfried M, Harris MB, Tatewaki M, Uemura K, Lawson DC, Mantyh CR, Pappas TN.“Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats.” Surgery 2007;142:376-383.

Ueno T, Oga A, Takahashi T, Pappas TN.“Small Intestinal Submucosa (SIS) in the repair of a cecal wound in unprepared bowel in rats.” Journal of Gastrointestinal Surgery 2007;11:918-922.

Wang ZQ, Watanabe Y, Noda T, Yoshida A, Oyama T, Toki A.“Morphologic evaluation of regenerated small bowel by small intestinal submucosa.” Journal of Pediatric Surgery 2005;40:1898-1902.

Wang ZQ, Watanabe Y, Toki A.“Experimental assessment of small intestinal submucosa as a small bowel graft in a rat model.” Journal of Pediatric Surgery 2003;38:1596-1601.

Wei RQ, Tan B, Tan MY, Luo JC, Deng L, Chen XH, Li XQ, Zuo X, Zhi W, Yang P, Xie HQ, Yang ZM.“Grafts of porcine small intestinal submucosa with cultured autologous oral mucosal epithelial cells for esophageal repair in a canine model.” Experimental Biology and Medicine 2009;234:453-461.

Wiedeman JE, Ritter EM.“Use of porcine small intestinal submucosa in Ehlers-Danlos syndrome Type IV.” American Surgeon 2003;69:424-426.

Zeng YJ, Quao AK, Yu JD, Zhao JB, Liao DH, Hu XH, Hans G.“Collagen fiber angle in the submucosa of small intestine and its application in gastroenterology.” World Journal of Gastroenterology 2003;9:804-807.

Zhang L, Liu Z, Cui P, Zhao D, Chen W.“SIS with tissue-cultured allogenic cartilages patch tracheoplasty in a rabbit model for tracheal defect.” Acta Otolaryngology 2007;127:631-636.

General Surgery

References noted with a yellow highlight refer to human patients.

Admire AA, Greenfeld JI, Cosentino CM, Ghory MJ, Samimi KJ“Repair of cloacal exstrophy, omphalocele, and gastroschisis using porcine small-intestinal submucosa or cadaveric skin homograft.” Plastic and Reconstructive Surgery 2003;112:1059-1062.

Agrawal V, Brown BN, Beattie AJ, Gilbert TW, Badylak SF.“Evidence of innervation following extracellular matrix scaffold-mediated remodelling of muscular tissues.” Journal of Tissue Engineering and Regenerative Medicine 2009;3:590-600.

Agresta F, Bedin N.“Transabdominal laparoscopic inguinal hernia repair: Is there a place for biological mesh?” Hernia 2008;12:609-612.

Al-Haddad AA, Hellinger MD, Akermant SC.“Surgisis mesh repair of a postsacrectomy perineal hernia along with posterior proctosigmoidectomy for concomitant stricture.” American Surgeon 2007;73:1129-1132.

Alaedeen DI, Lipman J, Medalie D, Rosen MJ.“The single-staged approach to the surgical management of abdominal wall hernias in contaminated fields.” Hernia 2007;11:41-45.

Amini A, Vaziri K, Nagle AP.“Simultaneous laparoscopic type III paraesophageal hernia repair with porcine small intestine submucosa and Roux-en-Y gastric bypass.” Surgery for Obesity and Related Diseases 2008;4:764-767.

Ansaloni L, Cambrini P, Catena F, De Savario S, Gagliardi S, Gazzotti F, Hodde JP, Metzger DW, DÕAlessandro L, Pinna AD.“Immune response to small intestinal submucosa (Surgisis) implant in humans: Preliminary observations..” Journal of Investigative Surgery 2007;20:237-241.

Ansaloni L, Catena F, Coccolini F, Fini M, Gazzotti F, Giardino R, Pinna AD.“Peritoneal adhesions to prosthetic materials: An experimental comparative study of treated and untreated polypropylene meshes placed in the abdominal cavity.” Journal of Laparoendoscopic and Advanced Surgical Techniques 2009;19:369-374.

Ansaloni L, Catena F, Coccolini F, Gazzotti F, D'Alessandro L, Pinna AD.“Inguinal hernia repair with porcine small intestine submucosa: 3-years follow-up results of a randomized controlled trial of lichtenstein's repair with polypropylene mesh vs. Surgisis IHM.” American Journal of Surgery 2009;198:303-312.

Ansaloni L, Catena F, Coccolini F, Negro P, Campanelli G, Miserez M.“New "biological" meshes: the need for a register. The EHS Registry for Biological Prostheses: Call for participating European surgeons.” Hernia 2009;13:103-108.

Ansaloni L, Catena F, Coccolini F, Negro P, Campanelli G, Miserez M.“New 'biological' meshes: the need for a register. The EHS Registry for Biological Prostheses: Call for participating European surgeons.” Hernia 2008 Oct 23. [Epub]

Ansaloni L, Catena F, D'Alessandro L“Prospective randomized, double-blind, controlled trial comparing Lichtenstein's repair of inguinal hernia with polypropylene mesh versus Surgisis gold soft tissue graft: preliminary results.” Acta Biomedica Ateneo Parmense 2003;74:10-14.

Ansaloni L, Catena F, Gagliardi S, Gazzotti F, D'Alessandro L, Pinna AD.“Hernia repair with porcine small-intestinal submucosa.” Hernia 2007;11:321-326.

Ayubi FS, Armstrong PJ, Mattia MS, Parker DM.“Abdominal wall hernia repair: a comparison of Permacol and Surgisis grafts in a rat hernia model.” Hernia 2008;12:373-378.

Bachman SL, Ramaswamy A, Ramshaw BJ.“Early results of midline hernia repair using a minimally invasive component separation technique.” American Surgeon 2009;75:572-578.

Badylak S, Kokini K, Tullius B, Simmons-Byrd A, Morff R.“Morphologic study of small intestinal submucosa as a body wall repair device.” Journal of Surgical Research 2002;103:190-202.

Badylak S, Kokini K, Tullius B, Whitson B.“Strength over time of a resorbable bioscaffold for body wall repair in a dog model.” Journal of Surgical Research 2001;99:282-287.

Baroncello JB, Czeczko NG, Malafaia O, Ribas-Filho JM, Nassif PAN, Dietz AU.“The repair of abdominal defects in rabbits with Parietex and Surgisis meshes abdominal wall.” Arquivos de Gastroenterologia 2008;45:323-329.

Bellón JM, Rodríguez M, Gómez-Gil V, Sotomayor S, Buján J, Pascual G.“Postimplant intraperitoneal behavior of collagen-based meshes followed by laparoscopy.” Surgical Endoscopy 2012;26:27-35.

Bellon-Caneiro JM, Carnicer-Escusol E, Rodriguez-Mancheno M, Garcia-Honduvilla N, Serrano-Amarilla N, Bujan-Varela J.“[Use of a composite prosthesis (PL-PU99) versus a biological prosthesis (Surgisis(R)) in an experimental model of temporary abdominal closure.]” Cirugia Espoanola 2005;78:103-108.

Bellows CF, Wheatley BM, Moroz K, Rosales SC, Morici LA.“The effect of bacterial infection on the biomechanical properties of biological mesh in a rat model.” PLoS One 2011;6(6):e21228.

Beres A, Christison-Lagay ER, Romao RL, Langer JC.“Evaluation of Surgisis for patch repair of abdominal wall defects in children.” Journal of Pediatric Surgery 2012;47:917-919.

Bettolli M, Rubin SZ, Gutauskas A.“Large paraesophageal hernias in children. Early experience with laparoscopic repair.” European Journal of Pediatric Surgery 2008;18:72-74.

Bhende S, Barbolt T, Rothenburger S, Piccoli L.“Infection potentiation study of synthetic and naturally derived surgical mesh in mice.” Surgical Infections 2007;8:405-414.

Bochicchio GV, Jain A, McGonigal K, Turner D, Ilahi O, Reese S, Bochicchio K.“Biologic vs synthetic inguinal hernia repair: 1-year results of a randomized double-blinded trial. ” Journal of the American College of Surgeons 2014;218:751-757.

Bochicchio GV, Jain A, McGonigal K, Turner D, Ilahi O, Reese S, Bochicchio K.“Biologic vs synthetic inguinal hernia repair: 1-year results of a randomized double-blinded trial. ” Journal of the American College of Surgeons 2014;218:751-757.

Bohm G, Binnebosel M, Karahling E, Schumpelick V, Steinau G, Stanzel S, Anurov M, Titkova S, Ottinger A, Speer M.“Influence of the elasticity module of synthetic and natural polymeric tissue substitutes on the mobility of the diaphragm and healing process in a rabbit model.” Journal of Biomaterials Applications 2011;25:771-793.

Boutros C, Somasundar P, Espat NJ.“Early results on the use of biomaterials as adjuvant to abdominal wall closure following cytoreduction and hyperthermic intraperitoneal chemotherapy.” World Journal of surgical Oncology 2010;8:72.

Bryan N, Ahswin H, Smart N, Bayon Y, Wohlert S, Hunt JA.“The in vivo evaluation of tissue-based biomaterials in a rat full-thickness abdominal wall defect model.” Journal of Biomedical Materials Research 2013 Oct 24. [E-pub]

Böhm G, Steinau G, Krähling E, Schumpelick V, Hermanns-Sachweh B, Stanzel S, Ottinger A.“Is biocompatibility affected by constant shear stress? - Comparison of three commercially available meshes in a rabbit model.” Journal of Biomaterials Applications 2011;25:721-741.

Catena F, Ansaloni L, Leone A, De Cataldis A, Gagliardi S, Gazzotti F, Peruzzi S, Agrusti S, D'Alessandro L, Taffurelli M.“Lichtenstein repair of inguinal hernia with Surgisis inguinal hernia matrix soft-tissue graft in immunodepressed patients.” Hernia 2005;9:29-31.

Clarke KM, Lantz GC, Salisbury SK, Badylak SF, Hiles MC, Voytik SL.“Intestine submucosa and polypropylene mesh for abdominal wall repair in dogs.” Journal of Surgical Research 1996;60:107-114.

Coccolini F, Catena F, Bertuzzo VR, Ercolani G, Pinna A, Ansaloni L.“Abdominal wall defect repair with biological prosthesis in transplanted patients: Single center retrospective analysis and review of the literature.” Updates in surgery 2013 May 1. [Epub]

Costa RG, Lontra MB, Scalco P, Cavazzola LT, Gurski RR.“Polylactic acid film versus acellular porcine small intestinal submucosa mesh in peritoneal adhesion formation in rats.” Acta Cirurgica Brasileira 2009;24:128-135.

Dalla Vecchia L, Engum S, Kogon B, Jensen E, Davis M, Grosfeld J.“Evaluation of small intestine submucosa and acellular dermis as diaphragmatic prostheses.” Journal of Pediatric Surgery 1999;34:167-171.

Daly K, Stewart-Akers A, Hara H, Ezzelarab M, Long C, Cordero K, Johnson S, Ayares D, Cooper D, Badylak SF.“Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.” Tissue Engineering Part A. 2009;15:3877-3888.

Dasgupta R, Wales PW, Zuker RM, Fisher DM, Langer JC.“The use of Surgisis for abdominal wall reconstruction in the separation of omphalopagus conjoined twins.” Pediatric Surgery International 2007;23:923-926.

de Castro Brás LE, Shurey S, Sibbons PD.“Evaluation of crosslinked and non-crosslinked biologic prostheses for abdominal hernia repair.” Hernia 2012;16:77-89.

De Ugarte DA, Puapong D, Roostaeian J, Gillis N, Fonkalsrud EW, Atkinson JB, Dunn JC.“Surgisis patch tracheoplasty in a rodent model for tracheal stenosis.” Journal of Surgical Research 2003;112:65-69.

Desai KM, Diaz S, Dorward IG, Winslow ER, La Regina MC, Halpin V, Soper NJ.“ Histologic results 1 year after bioprosthetic repair of paraesophageal hernia in a canine model.” Surgical Endoscopy 2006;20:1693-1697.

Ditzel M, Deerenberg EB, Grotenhuis N, Harlaar JJ, Monkhorst K, Bastiaansen-Jenniskens YM, Jeekel J, Lange JF.“Biologic meshes are not superior to synthetic meshes in ventral hernia repair: an experimental study with long-term follow-up evaluation.” Surgical Endoscopy 2013 Apr 3. [Epub]

Edelman DS, Bellows CF.“Umbilical herniorrhaphy reinforced with biologic mesh.” American Surgeon 2010;76:1205-1209.

Edelman DS, Hodde JP.“Update on bioactive prosthetic material for the treatment of hernias.” Surgical Techniques International 2012;XXI:135-139.

Edelman DS, Hodde JP.“Bioactive prosthetic material for treatment of hernias.” Surgery Technology International 2006;15:104-108.

Edelman DS, Selesnick H.“Sports hernia: treatment with biologic mesh (Surgisis) : A preliminary study.” Surgical Endoscopy 2006;20:971-973.

Edelman DS.“Fibrin glue fixation of bioactive extracellular matrix mesh compared with soft prolene mesh for laparoscopic hernia repair.” Surgical Laparoscopy, Endoscopy, and Percutaneous Techniques 2008;18:569-572.

Edelman DS.“Laparoscopic herniorrhaphy with porcine small intestinal submucosa: a preliminary study.” Journal of the Society of Laparoendoscopic Surgeons 2002;6:203-205.

Eid GM, Mattar SG, Hamad G, Cottam DR, Lord JL, Watson A, Dallal M, Schauer PR.“Repair of ventral hernias in morbidly obese patients undergoing laparoscopic gastric bypass should not be deferred.” Surgical Endoscopy 2004;18:207-210.

Eid GM, Wikiel KJ, Entabi F, Saleem M.“Ventral hernias in morbidly obese patients: A suggested algorithm for operative repair.” Obesity surgery 2013 Mar 14. [Epub]

Figel NA, Rostas JW, Ellis CN.“Outcomes using a bioprosthetic mesh at the time of permanent stoma creation in preventing a parastomal hernia: a value analysis.” American Journal of Surgery 2012;203:323-326.

Fine AP.“Laparoscopic repair of inguinal hernia using Surgisis meash and fibrin sealant.” Journal of the Society of Laparoendoscopic Surgeons 2006;10:461-465.

Franklin ME Jr, Gonzalez, JJ Jr, Glass JL.“Use of porcine small intestinal submucosa as a prosthetic device for laparoscopic repair of hernias in contaminated fields: 2-year follow-up.” Hernia 2004;8:186-189.

Franklin ME Jr, Trevio JM, Portillo G, Vela I, Glass JL, Gonz�lez JJ.“The use of porcine small intestinal submucosa as a prosthetic material for laparoscopic hernia repair in infected and potentially contaminated fields: long-term follow-up.” Surgical Endoscopy 2008;22:1941-1946.

Franklin ME, Gonzalez JJ, Michaelson RP, Glass JL, Chock DA.“Preliminary experience with new bioactive prosthetic material for repair of hernias in infected fields.” Hernia 2002;6:171-174.

Fumagalli U, Bona S, Caputo M, Elmore U, Battafarano F, Pestalozza A, Rosati R.“Are Surgisis biomeshes effective in reducing recurrences after laparoscopic repair of large hiatal hernias?” Surgical Laparoscopy, Endoscopy and Percutaneous Techniques 2008;18:433-436.

Gagliardi S, Ansaloni L, Catena F, Gazzotti F, D'Alessandro L, Pinna AD.“Hernioplasty with Surgisis Inguinal Hernia Matrix (IHM).” Surgical Technology International 2007;16:128-133.

García-Pumarino R, Pascual G, Rodríguez M, Pérez-Köhler B, Manuel Bellón J.“Do collagen meshes offer any benefits over preclude® ePTFE implants in contaminated surgical fields? A comparative in vitro and in vivo study.” Journal of Biomedical Materials Research B Applied Biomaterials 2013 Sep 2. [Epub]

Ginting N, Tremblay L, Kortbeek JB.“Surgisis® in the management of the complex abdominal wall in trauma: A case series and review of the literature.” Injury 2010;41:1052-1055.

Gomez NA, Zapatier JA, Vargas PE.“Small intestinal submucosa as a bioscaffold for biliary tract regeneration (Letter to the editor).” Surgery 2004;135:460.

Gonzalez R, Hill SJ, Mattar SG, Lin E, Ramshaw BJ, Smith CD, Wulkan ML.“Absorbable versus nonabsorbable mesh repair of congenital diaphragmatic hernias in a growing animal model.” Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. 2011;21:449-454.

Grethel EJ, Cortes RA, Wagner AJ, Clifton MS, Lee H, Farmer DL, Harrison MR, Keller RL, Nobuhara KK.“Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex.” Journal of Pediatric Surgery 2006;41:29-33.

Gupta A, Zahriya K, Mullens PL, Salmassi S, Keshishian A.“Ventral herniorrhaphy: experience with two different biosynthetic mesh materials, Surgisis and Alloderm.” Hernia 2006;10:419-425.

Guzzo JL, Bochicchio GV, Henry S, Keller E, Scalea TM.“Incarcerated inguinal hernia in the presence of Fournier's gangrene: a novel approach to a complex problem.” American Surgeon 2007;73:93-95.

Harth KC, Broome AM, Jacobs MR, Blatnik JA, Zeinali F, Bajaksouzian S, Rosen MJ.“Bacterial clearance of biologic grafts used in hernia repair: An experimental study.” Surgical Endoscopy 2011;25:2224-2229.

Helton WS, Fisichella PM, Berger R, Horgan S, Espat NJ, Abcarian H.“Short-term outcomes with small intestinal submucosa for ventral abdominal hernia.” Archives of Surgery 2005;140:549-562.

Ho CH, Liao PW, Yang SS, Jaw FS, Tsai YC.“The use of porcine small intestine submucosa implants might be associated with a high recurrence rate following laparoscopic herniorrhaphy.” Journal of the Formosan Medical Association 2013 May 28. [Epub]

Hodde JP, Suckow MA, Wolter WR, Hiles MC.“Small intestinal submucosa does not promote PAIII tumor growth in Lobund-Wistar rats.” Journal of Surgical Research 2004;120:189-194.

Holcomb GW, Ostlie DJ, Miller KA.“Laparoscopic patch repair of diaphragmatic hernias with Surgisis.” Journal of Pediatric Surgery 2005;40:E1-5.

Huber JE, Spievack A, Simmons-Byrd A, Ringel RL, Badylak S.“Extracellular matrix as a scaffold for laryngeal reconstruction.” Annals of Otology, Rhinology, and Laryngology 2003;112:428-433.

Jawaid WB, Qasem E, Jones MO, Shaw NJ, Losty PD.“Outcomes following prosthetic patch repair in newborns with congenital diaphragmatic hernia.” British Journal of Surgery 2013;100:1833-1837.

Jenkins ED, Lerdsirisopon S, Costello KP, Melman L, Greco SC, Frisella MM, Matthews BD, Deeken CR.“Laparoscopic fixation of biologic mesh at the hiatus with fibrin or polyethylene glycol sealant in a porcine model.” Surgical Endoscopy 2011;25:3405-3413.

Johnson BM, Ko JC, Hall PJ, Saunders AT, Lantz GC.“Analgesic effect of bupivacaine eluting porcine small intestinal submucosa (SIS) in ferrets undergoing acute abdominal hernia defect surgery.” Journal of Surgical Research 2011;167:e403-e412.

Johnson EK, Paquette EL.“Use of Surgisis for abdominal wall reconstruction/closure in battlefield casualties during Operation Iraqi Freedom.” Military Medicine 2007;172:1119-1124.

Jones VS, Thomas G, Stormon M, Shun A.“The ping-pong ball as a surgical aid in liver transplantation.” Journal of Pediatric Surgery 2008;43:1745-1748.

Karpelowsky JS, Thomas G, Shun A.“Definitive abdominal wall closure using a porcine intestinal submucosa biodegradable membrane in pediatric transplantation.” Pediatric Transplantation 2009;13:285-289.

Karpelowsky JS, Thomas G, Shun A.“Definitive abdominal wall closure using a porcine intestinal submucosa biodegradable membrane in pediatric transplantation.” Pediatric Transplantation 2008 Nov 10. [Epub]

Kathju S, Nistico L, Lasko LA, Stoodley P.“Bacterial biofilm on monofilament suture and porcine xenograft after inguinal herniorrhaphy.” FEMS Immunology and Medical Microbiology 2010;59:405-409.

Ko R, Kazacos EA, Snyder S, Ernst DM, Lantz GC.“Tensile strength comparison of small intestinal submucosa body wall repair.” Journal of Surgical Research 2006;135:9-17.

Konstantinovic ML, Ozog Y, Spelzini F, Pottier C, De Ridder D, Deprest J.“Biomechanical findings in rats undergoing fascial reconstruction with graft materials suggested as an alternative to polypropylene.” Neurourology and Urodynamics 2010;29:488-493.

Korwar V, Peters M, Adjepong S, Sigurdsson A.“Laparoscopic hiatus hernia repair and simultaneous sleeve gastrectomy: A novel approach in the treatment of gastroesophageal reflux disease associated with morbid obesity.” Journal of Laparoendoscopic and Advanced Surgical Techniques. Part A. 2009;19:761-763.

Lafosse A, de Magnee C, Brunati A, Bayet B, Vanwijck R, Manzanares J, Reding R.“Combination of tissue expansion and porcine mesh for secondary abdominal wall closure after pediatric liver transplantation.” Pediatric Transplantation 2012;16:e150-e152.

Lai JY, Chang PY, Lin JN.“Body wall repair using small intestinal submucosa seeded with cells.” Journal of Pediatric Surgery 2003;38:1752-1755.

Laituri CA, Garey CL, Ostlie DJ, Holcomb GW, Peter SD.“Morgagni hernia repair in children: comparison of laparoscopic and open results.” Journal of Laparoendoscopic and Advanced Surgical Techniques A 2011;21:89-91.

Laituri CA, Garey CL, Valusek PA, Fike FB, Kaye AJ, Ostlie DJ, Snyder CL, St Peter SD.“Outcome of congenital diaphragmatic hernia repair depending on patch type.” European Journal of Pediatric Surgery 2010;20:363-365.

Le Visage C, Yang SH, Kadakia L, Sieber AN, Kostuik JP, Leong KW.“Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration.” Spine 2006;31:2423-2431.

Lee AJ, Lee SH, Chung WH, Kim DH, Chung DJ, Do SH, Kim HY.“Evaluation of canine small intestinal submucosal xenograft and polypropylene mesh as bioscaffolds on an abdominal full-thickness resection model in growing rats.” Journal of Veterinary Science 2013;14:175-184.

Liu Z, Feng X, Wang H, Ma J, Liu W, Cui D, Gu Y, Tang R.“Carbon nanotubes as VEGF carriers to improve the early vascularization of porcine small intestinal submucosa in abdominal wall defect repair.” International Journal of Nanomedicine 2014;9:1275-1286.

Liu Z, Tang R, Zhou Z, Song Z, Wang H, Gu Y.“Comparison of two porcine-derived materials for repairing abdominal wall defects in rats.” PLoS One 2011;6:e20520.

Liu Z, Yang Z, Zhou Z, Song Z, Wang H, Yang J, Tang R, Tan Q, Gu Y.“Host tissue integration process in abdominal wall defect repair: a comparison of two porcine-derived grafts in a long-term study. Study ” Expert Opinion on Biological Therapy 2014 Apr 7[Epub]

Liu Z, Yang Z, Zhou Z, Song Z, Wang H, Yang J, Tang R, Tan Q, Gu Y.“Host tissue integration process in abdominal wall defect repair: a comparison of two porcine-derived grafts in a long-term study. Study ” Expert Opinion on Biological Therapy 2014 Apr 7[Epub]

Ma X, Zhang C, Zhang K.“[Experimental study on repairing rabbit femoral condyles defect by small intestinal submucosa and HA-TCP compositions at different ratios.]” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006;20:1061-1065.

Mak T, Howes R, Porter KM, Ismail T.“Management of a large abdominal wall defect using Surgisis and partial omentoplasty following blast injury in Afghanistan.” Injury Extra 2010;41:118-119.

Miedema BW, Bachman SL, Sporn E, Astudillo JA, Thaler K.“Transgastric placement of biologic mesh to the anterior abdominal wall.” Surgical Endoscopy 2009;23:1212-1218.

Morey P.“Repair of a laparostomy using biological mesh, topical negative pressure therapy and skin graft.” Wound Practice and Research 2011;19:130-134.

Naji H, Foley J, Ehren H.“Use of Surgisis for abdominal wall reconstruction in children with abdominal wall defects.” European Journal of Pediatric Surgery 2013 Sep 5. [Epub]

Napolitano L, Di Bartolomeo N, Aceto L, Waku M, Innocenti P.“[Use of prosthetic matherials in incisional hernias: our clinical experience].” Il Giornale di chirurgia 2004;25:141-145.

Nasr A, Struijs MC, Ein SH, Langer JC, Chiu PP.“Outcomes after muscle flap vs prosthetic patch repair for large congenital diaphragmatic hernias.” Journal of Pediatric Surgery 2010;45:151-154.

Nowak DD, Chin AC, Singer MA, Helton WS.“Large scrotal hernia: A complicated case of mesh migration, ascites, and bowel strangulation.” Hernia 2005;9:96-99.

Oelschlager BK, Pellegrini CA, Hunter J, Soper N, Brunt M, Sheppard B, Jobe B, Polissar N, Mitsumori L, Nelson J, Swanstrom L.“Biologic prosthesis reduces recurrence after laparoscopic paraesophageal hernia repair: A multicenter, prospective, randomized trial.” Annals of Surgery 2006;244:481-490.

Oelschlager BK, Pellegrini CA, Hunter JG, Brunt ML, Soper NJ, Sheppard BC, Polissar NL, Neradilek MB, Mitsumori LM, Rohrmann CA, Swanstrom LL.“Biologic prosthesis to prevent recurrence after laparoscopic paraesophageal hernia repair: Long-term follow-up from a multicenter, prospective, randomized trial.” Journal of the American College of Surgeons 2011;213:461-468.

Oelschlager BK, Petersen RP, Brunt LM, Soper NJ, Sheppard BC, Mitsumori L, Rohrmann C, Swanstrom LL, Pellegrini CA.“Laparoscopic paraesophageal hernia repair: defining long-term clinical and anatomic outcomes.” Journal of Gastrointestinal Surgery 2012;16:453-459.

Ort SA, Ehrlich HP, Isaacson JE.“Acellular porcine intestinal submucosa as fascial graft in an animal model: Applications for revision tympanoplasty.” Otolaryngology - Head and Neck Surgery 2010;143:435-440.

Ozog Y, Konstantinovic ML, Verschueren S, Spelzini F, De Ridder D, Deprest J.“Experimental comparison of abdominal wall repair using different methods of enhancement by small intestinal submucosa graft.” International Urogynecology Journal and Pelvic Floor Dysfunction 2009;20:435-441.

Pallati PK, Puri V, Mittal SK.“Gastric outlet obstruction secondary to Morgagni hernia: a case report.” Hernia 2008;12:209-212.

Pandit AS, Henry JA.“Design of surgical meshes - an engineering perspective.” Technology and Health Care 2004;12:51-65.

Pascual G, Rodríguez M, Sotomayor S, Moraleda E, Bellón JM.“Effects of collagen prosthesis cross-linking on long-term tissue regeneration following the repair of an abdominal wall defect.” Wound Repair and Regeneration 2012;20:402-413.

Pascual G, Sotomayor S, Pérez-López P, Buján J, Bellón JM.“Long term behavior of biological prostheses used as abdominal wall substitutes.” Histology and Histopathology 2013 Jul 19. [Epub]

Peeters E, van Barneveld KWY, Schreinemacher MH, De Hertogh G, Ing YO, Bouvy N, Miserez M.“One-year outcome of biological and synthetic bioabsorbable meshes for augmentation of large abdominal wall defects in a rabbit model.” Journal of Surgical Research 2013;180:274-283.

Petter-Puchner AH, Fortelny RH, Mittermayr R, Walder N, Ohlinger W, Redl H.“Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair.” Surgical Endoscopy 2006;20:942-946.

Petter-Puchner AH, Fortelny RH, Silic K, Brand J, Gruber-Blum S, Redl H.“Biologic hernia implants in experimental intraperitoneal onlay mesh plasty repair: the impact of proprietary collagen processing methods and fibrin sealant application on tissue integration.” Surgical Endoscopy 2011;25:3245-3252.

Petter-Puchner AH, Fortelny RH, Walder N, Morales-Conde S, Gruber-Blum S, Ohlinger W, Redl H.“Small intestine submucosa (SIS) implants in experimental IPOM repair.” Journal of Surgical Research 2010;161:264-271.

Poulose BK, Scholz S, Moore DE, Schmidt CR, Grogan EL, Lao OB, Nanney L, Davidson J, Holzman MD.“Physiologic properties of small intestine submucosa.” Journal of Surgical Research 2005;123:262-267.

Prevel CD, Eppley BL, Summerlin DJ, Jackson JR, McCarty M, Badylak SF.“Small intestinal submucosa: utilization for repair of rodent abdominal wall defects.” Annals of Plastic Surgery 1995;35:374-380.

Puccio F, Solazzo M, Marciano P.“Comparison of three different mesh materials in tension-free inguinal hernia repair: Prolene versus Vypro versus Surgisis.” International Surgery 2005;90:S21-S23.

Puglisi F, Capuano P, Iambrenghi OC, Armenise N, Carlucci F, Memeo M, Memeo R, Martines G.“Laparoscopic repair of Morgagni hernia in an adult: use of a porcine small intestine submucosa biocompatible prosthesis.” Chirurgia Italiana 2009;61:351-356.

Rauth TP, Poulose BK, Nanney LB, Holzman MD.“A comparative analysis of expanded polytetrafluoroethylene and small intestinal submucosa-implications for patch repair in ventral herniorrhaphy.” Journal of Surgical Research 2007;143:43-49.

Rice RD, Ayubi FS, Shaub ZJ, Parker DM, Armstrong PJ, Tsai JW.“Comparison of Surgisis®, AlloDerm®, and Vicryl Woven Mesh® grafts for abdominal wall defect repair in an animal model.” Aesthetic Plastic Surgery 2010;34:290-296.

Romao RL, Nasr A, Chiu PP, Langer JC.“What is the best prosthetic material for patch repair of congenital diaphragmatic hernia? Comparison and meta-analysis of porcine small intestinal submucosa and polytetrafluoroethylene.” Journal of Pediatric Surgery 2012;47:1496-500.

Ross JW.“Pelvic Floor Hernias: Tissue Repair or Replacement?” Laparoscopy and SLS Report 2003;2:12-16.

Sandor M, Xu H, Connor J, Lombardi J, Harper JR, Silverman RP, McQuillan DJ.“Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair.” Tissue Engineering 2008;14:2021-2031.

Sandoval JA, Lou D, Engum SA, Fisher LM, Bouchard CM, Davis MM, Grosfeld JL.“The whole truth: comparative analysis of diaphragmatic hernia repair using 4-ply vs 8-ply small intestinal submucosa in a growing animal model.” Journal of Pediatric Surgery 2006;41:518-523.

Shah BC, Tiwari MM, Goede MR, Eichler MJ, Hollins RR, McBride CL, Thompson JS, Oleynikov D.“Not all biologics are equal!” Hernia 2011;15:165-171.

Sicari BM, Johnson SA, Siu BF, Crapo PM, Daly KA, Jiang H, Medberry CJ, Tottey S, Turner NJ, Badylak SF.“The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold.” Biomaterials 2012;33:5524-5533.

Smith MJ, Paran TS, Quinn F, Corbally MT.“The SIS extracellular matrix scaffold-preliminary results of use in congenital diaphragmatic hernia (CDH) repair.” Pediatric Surgery International 2004;20:859-862.

Soccol AT, Bettega S, Noronha L, Sass S, Soccol VT, Scholz MR, Mocellin M.“[Defect repair in rat mandible with hydroxyapatite cement compared to small intestine submucosa].” Rev Bras Otorrinolaringol (Engl Ed). 2006;72:195-199.

Soiderer EE, Lantz GC, Kazacos EA, Hodde JP, Wiegand RE.“Morphologic study of three collagen materials for body wall repair.” Journal of Surgical Research 2004;118:161-175.

Song Z, Peng Z, Liu Z, Yang J, Tang R, Yan G.“Reconstruction of abdominal wall musculofascial defects with SIS scaffolds seeded with tenocytes in rats.” Tissue Engineering Part A 2013;19:1543-1553.

St Peter SD, Ostlie DJ, Holcomb GW 3rd.“The use of biosynthetic mesh to enhance hiatal repair at the time of redo Nissen fundoplication.” Journal of Pediatric Surgery 2007;42:1298-1301.

St Peter SD, Valusek PA, Tsao K, Holcomb GW 3rd, Ostlie DJ, Snyder CL.“Abdominal complications related to type of repair for congenital diaphragmatic hernia.” Journal of Surgical Research 2007;140:234-236.

Stadlhuber RJ, Sherif AE, Mittal SK, Fitzgibbons RJ Jr, Michael Brunt L, Hunter JG, Demeester TR, Swanstrom LL, Daniel Smith C, Filipi CJ.“Mesh complications after prosthetic reinforcement of hiatal closure: a 28-case series.” Surgical Endoscopy 2009;23:1219-1226.

Steurer JA, Lantz GC, Kazacos EA, Saunders AT, Altizer AM.“Chronic hernia repair in a rat model using small intestinal submucosa.” Journal of Investigative Surgery 2011;24:227-235.

Stoll MR, Cook JL, Pope ER, Carson WL, Kreeger JM.“The use of porcine small intestinal submucosa as a biomaterial for perineal herniorrhaphy in the dog.” Veterinary Surgery 2002;31:379-390.

Strange PS.“Small intestinal submucosa for laparoscopic repair of large paraesophageal hiatal hernias: a preliminary report.” Surgical Technology International 2003;11:141-143.

Suckow MA, Hodde JP, Wolter WR, Wood KV, Hiles MC, Janis AD.“Addition of nimesulide to small intestinal submucosa biomaterial inhibits postsurgical adhesiogenesis in rats.” Journal of Biomedical Materials Research B. Applied Biomaterials 2010;93:18-23.

Suckow MA, Wolter WR, Fecteau C, Labadie-Suckow SM, Johnson C.“Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair device.” Journal of Biomaterials Applications 2012;27:231-237.

Swain JM, Klaus A, Achem SR, Hinder RA.“Congenital diaphragmatic hernia in adults.” Seminars in Laparoscopic Surgery 2001;8:246-255.

Thomas N, Thomas G, Verran D, Stormon M, O'Loughlin E, Shun A.“Liver transplantation in children with hyper-reduced grafts - A single-center experience.” Pediatric Transplantation 2010;14:426-430.

Trevino JM, Franklin ME Jr, Berghoff KR, Glass JL, Jaramillo EJ.“Preliminary results of a two-layered prosthetic repair for recurrent inguinal and ventral hernias combining open and laparoscopic techniques.” Hernia 2006;10:253-257.

Turner NJ, Londono R, Dearth CL, Culiat CT, Badylak SF.“Human NELL1 protein augments constructive tissue remodeling with biologic scaffolds.” Cells Tissues Organs 2013 Dec 7. [Epub]

Tuveri M, Tuveri A, Nicolò E.“Repair of large abdominal incisional hernia by reconstructing the midline and use of an onlay of biological material.” American Journal of Surgery 2011;202:e7-e11.

Ueno T, Pickett LC, de la Fuente SG, Lawson DC, Pappas TN.“Clinical application of porcine small intestinal submucosa in the management of infected or potentially contaminated abdominal defects.” Journal of Gastrointestinal Surgery 2004;8:109-112.

Ulmer TF, Stumpf M, Rosch R, Junge K, Binnebösel M, Trotha KT, Oettinger AP, Neumann U.“Suture-free and mesh reinforced small intestinal anstomoses: a feasibility study in rabbits.” Journal of Investigative Surgery 2013;26:210-216.

Valentin JE, Turner NJ, Gilbert TW, Badylak SF.“Functional skeletal muscle formation with a biologic scaffold.” Biomaterials 2010;31:7475-7484.

Voskerician G, Jin J, White MF, Williams CP, Rosen MJ.“Effect of biomaterial design criteria on the performance of surgical meshes for abdominal hernia repair: a pre-clinical evaluation in a chronic rat model.” Journal of Materials Science: Materials in Medicine 2010;21:1989-1995.

Walter CJ, Beral DL, Drew P.“Optimum mesh and port sizes for laparoscopic incisional hernia repair.” Journal of Laparoendoscopic and Advanced Surgical Techniques 2007;17:58-63.

Wassenaar EB, Mier F, Sinan H, Petersen RP, Martin AV, Pellegrini CA, Oelschlager BK.“The safety of biologic mesh for laparoscopic repair of large, complicated hiatal hernia.” Surgical Endoscopy 2012;26:1390-1396.

Winkler JT, Swaim SF, Sartin EA, Henderson RA, Welch JA.“The effect of a porcine-derived small intestinal submucosa product on wounds with exposed bone in dogs.” Veterinary Surgery 2002;31:541-551.

Yamakado K, Pavcnik D, Uchida BT, Timmermans H, Corless CL, Park JW, Yamada K, Keller FS, Rosch J.“Biliary small intestinal submucosa covered Z-stents: preliminary results in an animal model.” Radiology Oncology 2001;35:1-10.

Zhang J, Wang GY, Xiao YP, Fan LY, Wang Q.“The biomechanical behavior and host response to porcine-derived small intestine submucosa, pericardium and dermal matrix acellular grafts in a rat abdominal defect model.” Biomaterials 2011;32:7086-7095.

Zhang X, Luo J, Yang Z.“[Elementary evaluation of small intestinal submucosa and polypropylene mesh used for repairing abdominal wall defect in rats].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2005;19:574-577.

Zhang Y, Frimberger D, Cheng EY, Lin HK, Kropp BP.“Challenges in a larger bladder replacement with cell-seeded and unseeded small intestinal submucosa grafts in a subtotal cystectomy model.” BJU International 2006;98:1100-1105.

Immunology

References noted with a yellow highlight refer to human patients.

Aachoui Y, Ghosh SK.“Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice: Relative efficacy and safety.” BMC Immunology 2011;12:61.

Aachoui Y, Ghosh SK.“Extracellular matrix from porcine small intestinal submucosa (SIS) as immune adjuvants.” PLoS One 2011;6:e27083.

Allman AJ, McPherson TB, Badylak SF, Merrill LC, Kallakury B, Sheehan C, Raeder RH, Metzger DW.“Xenogeneic extracellular matrix grafts elicit a th2-restricted immune response.” Transplantation 2001;71:1631-1340.

Allman AJ, McPherson TB, Merrill LC, Badylak SF, Metzger DW“The Th2-restricted immune response to xenogeneic small intestinal submucosa does not influence protective immunity to viral and bacterial pathogens.” Tissue Engineering 2002;8:53-62.

Brown BN, Valentin JE, Stewart-Akers AM, McCabe GP, Badylak SF.“Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component.” Biomaterials 2009;30:1482-1491.

Harlan DM, Karp CL, Matzinger P, Munn DH, Ransohoff RM, Metzger DW.“Immunological concerns with bioengineering approaches.” Annals of the New York Academy of Sciences 2002;961:323-330.

Keane TJ, Londono R, Turner NJ, Badylak SF.“Consequences of ineffective decellularization of biologic scaffolds on the host response.” Biomaterials 2012;33:1771-1781.

McPherson TB, Liang H, Record RD, Badylak SF.“Gal alpha (1,3) Gal epitope in porcine small intestinal submucsa (SIS).” Tissue Engineering 2000;6:233-239.

Metzger DW.“Immune responses to tissue-engineered extracellular matrix used as a bioscaffold.” Annals of the New York Academy of Sciences 2002;961:335-336.

Orenstein SB, Qiao Y, Klueh U, Kreutzer DL, Novitsky YW.“Activation of human mononuclear cells by porcine biologic meshes in vitro.” Hernia 2010;14:401-407.

Palmer EM, Baum LG, Van Seventer GA.“Small Intestinal Submucosa (SIS) induces loss of mitochondrial integrity and caspase-dependent apoptosis in human T cells.” Tissue Engineering 2003;9:307-314.

Palmer EM, Beilfuss BA, Nagai T, Semnani RT, Badylak SF, Van Seventer GA.“Human helper T cell activation and differentiation is suppressed by porcine small intestinal submucosa.” Tissue Engineering 2002;8:893-900.

Raeder RH, Badylak SF, Sheehan C, Kallakury B, Metzger DW.“Natural anti-galactose alpha1,3 galctose antibodies delay, but do not prevent the acceptance of extracellular matrix xenografts.” Transplant Immunology 2002;10:15-24.

Song KH.“An in vivo study of the host tissue response to subcutaneous implantation of PLGA- and/or porcine small intestinal submucosa-based scaffolds.” Biomaterials 2007;28:5137-5143.

Valentin JE, Stewart-Akers AM, Gilbert TW, Badylak SF.“Macrophage participation in the degradation and remodeling of ECM scaffolds.” Tissue Engineering Part A 2009;15:1687-1694.

Material Properties

References noted with a yellow highlight refer to human patients.

Abraham GA, Murray J, Billiar K, Sullivan SJ“Evaluation of the porcine intestinal collagen layer as a biomaterial.” Journal of Biomedical Materials Research 2000;51:442-452.

Androjna C, Gatica JE, Belovich JM, Derwin KA.“Oxygen diffusion through natural extracellular matrices: Implications for estimating 'critical thickness' values in tendon tissue engineering.” Tissue Engineering 2008;14:559-569.

Annor AH, Tang ME, Pui CL, Ebersole GC, Frisella MM, Matthews BD, Deeken CR.“Effect of enzymatic degradation on the mechanical properties of biological scaffold materials.” Surgical Endoscopy 2012;26:2767-2778.

Arnold GA, Mathews KG, Roe S, Mente P, Seaboch T.“Biomechanical comparison of four soft tissue replacement materials: an in vitro evaluation of single and multilaminate porcine small intestinal submucosa, canine fascia lata, and polypropylene mesh.” Veterinary Surgery 2009;38:834-844.

Barber FA, Herbert MA, Coons DA.“Tendon augmentation grafts: biomechanical failure loads and failure patterns.” Arthroscopy 2006;22:534-538.

Billiar K, Murray J, Laude D, Abraham G, Bachrach N“Effects of carbodiimide crosslinking conditions on the physical properties of laminated intestinal submucosa.” Journal of Biomedical Materials Research 2001;56:101-108.

Brown BN, Barnes CA, Kasick RT, Michel R, Gilbert TW, Beer-Stolz D, Castner DG, Ratner BD, Badylak SF.“Surface characterization of extracellular matrix scaffolds.” Biomaterials 2010;31:428-437.

Davis LM, Callanan A, Carroll GT, Doyle BJ, Walsh MT, McGloughlin TM“On the potential of hydrated storage for naturally derived ECMs and associated effects on mechanical and cellular performance” Journal of Biomedical Materials Research B: Applied Biomaterials 2013 Jul 13. [Epub]

Deeken CR, Eliason BJ, Pichert MD, Grant SA, Frisella MM, Matthews BD.“Differentiation of biologic scaffold materials through physicomechanical, thermal, and enzymatic degradation techniques.” Annals of Surgery 2012;255:595-604.

Derwin KA, Baker AR, Spragg RK, Leigh DR, Iannotti JP.“Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties.” Journal of Bone and Joint Surgery 2006;88:2665-2672.

Feng C, Xu YM, Fu Q, Zhu WD, Cui L, Chen J.“Evaluation of the biocompatibility and mechanical properties of naturally derived and synthetic scaffolds for urethral reconstruction.” Journal of Biomedical Materials Research A 2010;94:317-325.

Ferrand BK, Kokini K, Badylak SF, Geddes LA, Hiles MC, Morff RJ.“Directional porosity of porcine small-intestinal submucosa.” Journal of Biomedical Materials Research 1993;27:1235-1241.

Freytes DO, Badylak SF, Webster TJ, Geddes LA, Rundell AE.“Biaxial strength of multilaminated extracellular matrix scaffolds.” Biomaterials 2004;25:2353-2361.

Freytes DO, Rundell AE, Vande Geest J, Vorp DA, Webster TJ, Badylak SF.“Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test.” Biomaterials 2005;26:5518-5531.

Freytes DO, Stoner RM, Badylak SF.“Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds.” Journal of Biomedical Materials Research 2008;84:408-414.

Freytes DO, Tullius RS, Valentin JE, Stewart-Akers AM, Badylak SF.“Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder.” Journal of Biomedical Materials Research 2008;87:862-872.

Gilbert TW, Sacks MS, Grashow JS, Woo SL, Badylak SF, Chancellor MB.“Fiber kinematics of small intestinal submucosa under biaxial and uniaxial stretch.” Journal of Biomechanical Engineering 2006;128:890-898.

Gilbert TW, Stolz DB, Biancaniello F, Simmons-Byrd A, Badylak SF.“Production and characterization of ECM powder: implications for tissue engineering applications.” Biomaterials 2005;26:1431-1435.

Gilbert TW, Wognum S, Joyce EM, Freytes DO, Sacks MS, Badylak SF.“Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix.” Biomaterials 2008;29:4775-4782.

Gloeckner DC, Sacks MS, Billiar KL, Bachrach N.“Mechanical evaluation and design of a multilayered collagenous repair biomaterial.” Journal of Biomedical Materials Research 2000;52:365-373.

Hiles MC, Badylak SF, Geddes LA, Kokini K, Morff RJ.“Porosity of porcine small-intestinal submucosa for use as a vascular graft.” Journal of Biomedical Materials Research 1993;27:139-144.

Hodde J, Hiles M.“Virus safety of a porcine-derived medical device: Evaluation of a viral inactivation method.” Biotechnology and Bioengineering 2002;79:211-216.

Janis AD, Johnson CC, Ernst DM, Brightman AO.“Structural characteristics of small intestinal submucosa constructs dictate in vivo incorporation and angiogenic response.” Journal of Biomaterials Applications 2012;26:1013-1033.

Lawrence BJ, Maase EL, Lin HK, Madihally SV.“Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa.” Journal of Biomedical Materials Research 2009;88A:634-643.

Leng Y, Ding Z, Gong L.“[Elastic modulus of small intestinal submucosa].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006;20:292-294.

Luo JC, Chen W, Chen XH, Qin TW, Huang YC, Xie HQ, Li XQ, Qian ZY, Yang ZM.“A multi-step method for preparation of porcine small intestinal submucosa (SIS).” Biomaterials 2011;32:706-713.

Mirani RD, Pratt J, Iyer P, Madihally SV.“The stress relaxation characteristics of composite matrices etched to produce nanoscale surface features” Biomaterials 2009;30:703-710.

Nicoson ZR, Buckley CA“Bond strength of fibrin glue between layers of porcine small intestine submucosa (SIS).” Biomedical Sciences Instrumentation 2002;38:179-184.

Obermiller FJ, Hodde JP, McAlexander CS, Kokini K, Badylak SF.“A comparison of suture retention strengths for three biomaterials.” Medical Science Monitor 2004;10:PI1-5.

Pui CL, Tang ME, Annor AH, Ebersole GC, Frisella MM, Matthews BD, Deeken CR.“Effect of repetitive loading on the mechanical properties of biological scaffold materials.” Journal of the American College of Surgeons 2012;215:216-228.

Raghavan D, Kropp BP, Lin HK, Zhang Y, Cowan R, Madihally SV.“Physical characteristics of small intestinal submucosa scaffolds are location-dependent.” Journal of Biomedical Materials Research 2005;73A:90-96.

Roeder R, Wolfe J, Lianakis N, Hinson T, Geddes LA, Obermiller J.“Compliance, elastic modulus, and burst pressure of small-intestine submucosa (SIS), small-diameter vascular grafts.” Journal of Biomedical Materials Research 1999;47:65-70.

Sacks MS, Gloeckner GC.“Quantification of the fiber architecture and biaxial mechanical behavior of porcine intestinal submucosa.” Journal of Biomedical Materials Research 1999;46:1-10.

Schäfer-Nolte F, Hennecke K, Reimers K, Schnabel R, Allmeling C, Vogt PM, Kuhbier JW, Mirastschijski U.“Biomechanics and biocompatibility of woven spider silk meshes during remodeling in a rodent fascia replacement model.” Annals of Surgery 2013 Jul 18. [Epub]

Stankus JJ, Freytes DO, Badylak SF, Wagner WR.“Hybrid nanofibrous scaffolds from electrospinning of a synthetic biodegradable elastomer and urinary bladder matrix.” Journal of Biomaterials Sciences Polymer Edition 2008;19:635-652.

Tottey S, Johnson SA, Crapo PM, Reing JE, Zhang L, Jiang H, Medberry CJ, Reines B, Badylak SF.“The effect of source animal age upon extracellular matrix scaffold properties.” Biomaterials 2011;32:128-136.

Tseng SJ, Chuang CJ, Tang SC.“Electrostatic immobilization of DNA polyplexes on small intestinal submucosa for tissue substrate-mediated transfection.” Acta Biomaterialia 2008;4:799-807.

Valentin JE, Freytes DO, Grasman JM, Pesyna C, Freund J, Gilbert TW, Badylak SF.“Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering.” Journal of Biomedical Materials Research 2009;91:1010-1017.

Valentin JE, Freytes DO, Grasman JM, Pesyna C, Freund J, Gilbert TW, Badylak SF.“Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering.” Journal of Biomedical Materials Research 2008 Dec 18. [Epub]

Whitson BA, Cheng BC, Kokini K, Badylak SF, Patel U, Morff R, O'Keefe CR.“Multilaminate resorbable biomedical device under biaxial loading.” Journal of Biomedical Materials Research 1998;43:277-281.

You Q, Wang F, Duan L, Du X, Xiao M, Shen Z.“Construction of small-caliber, polydioxanone cyclohexanone vascular stents.” Cell Biochemistry & Biophyisics 2010;57:35-43.

Zheng MH, Chen J, Kirilak Y, Willers C, Xu J, Wood D.“Porcine small intestine submucosa (SIS) is not an acellular collagenous matrix and contains porcine DNA: Possible implications in human implantation.” Journal of Biomedical Materials Research B Applied Biomaterials 2005;73B:61-67.

Neurology

References noted with a yellow highlight refer to human patients.

Alexander NS, Chaaban MR, Riley KO, Woodworth BA.“Treatment strategies for lateral sphenoid sinus recess cerebrospinal fluid leaks.” Archives of Otolaryngology--Head & Neck Surgery 2012;138:471-478.

Bejjani GK, Zabramski J, Durasis Study Group.“Safety and efficacy of the porcine small intestinal submucosa dural substitute: results of a prospective multicenter study and literature review.” Journal of Neurosurgery 2007;106:1028-1033.

Blount A, Riley K, Cure J, Woodworth BA.“Cerebrospinal fluid volume replacement following large endoscopic anterior cranial base resection.” International Forum of Allergy & Rhinology 2012;2:217-221.

Chaaban MR, Conger B, Riley KO, Woodworth BA.“Transnasal endoscopic repair of posterior table fractures.” Otolaryngology - Head and Neck Surgery 2012;147:1142-147.

Cobb MA, Badylak SF, Janas W, Boop FA.“Histology after dural grafting with small intestinal submucosa.” Surgical Neurology 1996;46:389-394.

Cobb MA, Badylak SF, Janas W, Simmons-Byrd A, Boop FA.“Porcine small intestinal submucosa as a dural substitute.” Surgical Neurology 1999;51:99-104.

Ducic I, Fu R, Iorio ML.“Innovative treatment of peripheral nerve injuries: combined reconstructive concepts.” Annals of Plastic Surgery 2012;68:180-187.

Eggink AJ, Roelofs LA, Feitz WF, Wijnen RM, Mullaart RA, Grotenhuis JA, van Kuppevelt TH, Lammens MM, Crevels AJ, Hanssen A, van den Berg PP.“In utero repair of an experimental neural tube defect in a chronic sheep model using biomatrices.” Fetal Diagnostics and Therapeutics 2005;20:335-340.

Eggink AJ, Roelofs LA, Lammens MM, Feitz WF, Wijnen RM, Mullaart RA, van Moerkerk HT, van Kuppevelt TH, Crevels AJ, Hanssen A, Lotgering FK, van den B“Histological evaluation of acute covering of an experimental neural tube defect with biomatrices in fetal sheep.” Fetal Diagnostics and Therapeutics 2006;21:210-216.

Fandiño M, Macdonald K, Singh D, Whyne C, Witterick I.“Determining the best graft-sealant combination for skull base repair using a soft tissue in vitro porcine model.” International Forum of Allergy and Rhinology 2012 Oct 25 [Epub]

Hadlock TA, Sundback CA, Hunter DA, Vacanti JP, Cheney ML.“A new artificial nerve graft containing rolled schwann cell monolayers.” Microsurgery 2001;21:96-101.


Haq I, Cruz-Almeida Y, Siqueira EB, Norenberg M, Green BA, Levi AD.“Postoperative fibrosis after surgical treatment of the porcine spinal cord: a comparison of dural substitutes.” Journal of Neurosurgery Spine 2005;2:50-54.

Hong S, Kim G.“Electrospun micro/nanofibrous conduits composed of poly(epsilon-caprolactone) and small intestine submucosa powder for nerve tissue regeneration.” Journal of Biomedical Materials Research Part B: Applied Biomaterials 2010;94:421-428.

Illing E, Chaaban MR, Riley KO, Woodworth BA.“Porcine small intestine submucosal graft for endoscopic skull base reconstruction.” International Forum of Allergy and Rhinology 2013 Aug 16. [Epub]

Jones V, Virgin F, Riley K, Woodworth BA.“Changing paradigms in frontal sinus cerebrospinal fluid leak repair.” International Forum of Allergy & Rhinology 2012;2:227-232.

Kang KN, Lee JY, Kim DY, Lee BN, Ahn HH, Lee B, Khang G, Park SR, Min BH, Kim JH, Lee HB, Kim MS.“Regeneration of Completely Transected Spinal Cord using Scaffold of Poly(D,L-lactide-co-glycolide)/Small Intestinal Submucosa seeded with rat bone marrow stem cells.” Tissue Engineering Part A 2011;17:2143-2152.

Kim KS, Lee JY, Kang YM, Kim ES, Kim GH, Rhee SD, Cheon HG, Kim JH, Min BH, Lee HB, Kim MS.“Small intestine submucosa sponge for in vivo support of tissue-engineered bone formation in the presence of rat bone marrow stem cells.” Biomaterials 2010;31:1104-1113.

Kokkalis ZT, Pu C, Small GA, Weiser RW, Venouziou AI, Sotereanos DG.“Assessment of processed porcine extracellular matrix as a protective barrier in a rabbit nerve wrap model.” Journal of Reconstructive Microsurgery 2011;27:19-28.

Smith RM, Wiedl C, Chubb P, Greene CH.“Role of small intestine submucosa (SIS) as a nerve conduit: Preliminary report.” Journal of Investigative Surgery 2004;17:339-344.

Virgin F, Barañano CF, Riley K, Woodworth BA.“Frontal sinus skull base defect repair using the pedicled nasoseptal flap.” Otolaryngology - Head and Neck Surgery 2011;145:338-340.

Xei X, Zhang C, Su Y.“[Comparison between effects of small intestinal submucosa graft and inside-out vein graft on repairing peripheral nerve defects].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007;21:149-153.

Yi JS, Lee HJ, Lee HJ, Lee IW, Yang JH.“Rat peripheral nerve regeneration using nerve guidance channel by porcine small intestinal submucosa.” Journal of Korean Neurosurgical Society 2013;53:65-71.

Ophthalmology

References noted with a yellow highlight refer to human patients.

Briksawan P, Wongaumnuaykul S, Tuntivanich P, Tuntivanich N, Sunthornvipat K.“The use of porcine small intestinal submucosa (PSIS) in a canine deep corneal ulcer.” Thai Journal of Veterinary Medicine 2003;33:101-106.

Duffy MT, Bloom JN, McNally-Heintzelman KM, Heintzelman DL, Soller EC, Hoffman GT.“Sutureless ophthalmic surgery: a scaffold-enhanced bioadhesive technique.” J AAPOS 2005;9:315-320.

Goulle F.“Use of porcine small intestinal submucosa for corneal reconstruction in dogs and cats: 106 cases.” Journal of Small Animal Practice 2012;53:34-43.

Griguer F, Raymond I, Regnier A.“[Preliminary evaluation of the biocompatibility of the small intestinal submucosa (SIS) biomaterial with the rabbit cornea].” Revue Med Vet 2001;152:597-604.

Vanore M, Chahory S, Payen G, Clerc B.“Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats.” Veterinary Ophthalmology 2007;10:93-99.

Orthopedics

References noted with a yellow highlight refer to human patients.

Aiken SW, Badylak SF, Toombs JP, Shelbourne KD, Hiles MC, Lantz GC, Van Sickle D.“Small intestinal submucosa as an intra-articular ligamentous graft material: a pilot study in dogs.” Veterinary and Comparative Orthopaedics and Traumatology 1994;7:124-128.

Arnoczky SP.“Building a meniscus - Biologic considerations.” Clinical Orthopaedics and Related Research 1999;367S:S244-S253.

Badylak S, Arnoczky S, Plouhar P, Haut R, Mendenhall V, Clarke R, Horvath C.“Naturally occurring extracellular matrix as a scaffold for musculoskeletal repair.” Clinical Orthopaedics and Related Research 1999;367S:S333-S343.

Badylak SF, Tullius R, Kokini K, Shelbourne KD, Klootwyk T, Voytik SL, Kraine MR, Simmons C.“The use of xenogeneic small intestinal submucosa as a biomaterial for Achille's tendon repair in a dog model.” Journal of Biomedical Materials Research 1995;29:977-985.

Badylak SF, Wu CC, Bible M, McPherson E.“Host protection against deliberate bacterial contamination of an extracellular matrix bioscaffold versus DacronTM mesh in a dog model of orthopedic soft tissue repair.” Journal of Biomedical Materials Research 2003;67B:648-654.

Beattie AJ, Gilbert TW, Guyot JP, Yates AJ, Badylak SF.“Chemoattraction of progenitor cells by remodeling extracellular matrix scaffolds.” Tissue Engineering 2009;15:1119-1125.

Beatty MW, Ojha AK, Cook JL, Alberts LR, Mahanna GK, Iwasaki LR, Nickel JC.“Small intestinal submucosa versus salt-extracted polyglycolic acid-poly-L-lactic acid: A comparison of neocartilage formed in two scaffold materials.” Tissue Engineering 2002;8:955-968.

Bertone AL, Goin S, Kamei SJ, Mattoon JS, Litsky AS, Weisbrode SE, Clarke RB, Plouhar PL, Kaeding CC.“Metacarpophalangeal collateral ligament reconstruction using small intestinal submucosa in an equine model.” Journal of Biomedical Materials Research 2008;84:219-229.

Bibbo C.“The porcine small intestinal submucosa (SIS) patch in foot and ankle reconstruction.” Journal of Foot and Ankle Surgery 2010;49:123-127.

Bradley MP, Fadale PD, Hulstyn MJ, Muirhead WR, Lifrak JT.“Porcine small intestine submucosa for repair of goat meniscal defects.” Orthopedics 2007;30:650-656.

Brune T, Borel A, Gilbert TW, Franceschi JP, Badylak SF, Sommer P.“In vitro comparison of human fibroblasts from intact and ruptured ACL for use in tissue engineering.” European Cells and Materials 2007;14:78-91.

Chai W, Ni M, Rui YF, Zhang KY, Zhang Q, Xu LL, Chan KM, Li G, Wang Y.“Effect of growth and differentiation factor 6 on the tenogenic differentiation of bone marrow-derived mesenchymal stem cells.” Chinese Medical Journal (English) 2013;126:1509-1516.

Chen JM, Willers C, Xu J, Wang A, Zheng MH.“Autologous tenocyte therapy using porcine-derived bioscaffolds for massive rotator cuff defect in rabbits.” Tissue Engineering 2007;13:1479-1491.

Cook JL, Fox DB, Kuroki K, Jayo M, De Deyne PG.“In vitro and in vivo comparison of five biomaterials used for orthopedic soft tissue augmentation.” American Journal of Veterinary Research 2008;69:148-156.

Cook JL, Fox DB, Malaviya P, Tomlinson JL, Farr J, Kuroki K, Cook CR.“Evaluation of small intestinal submucosa grafts for meniscal regeneration in a clinically relevant posterior meniscectomy model in dogs.” Journal of Knee Surgery 2006;19:159-167.

Cook JL, Fox DB, Malaviya P, Tomlinson JL, Kuroki K, Cook CR, Kladakis S.“Long-term outcome for large meniscal defects treated with small intestinal submucosa in a dog model.” American Journal of Sports Medicine 2006;34:32-42.

Cook JL, Tomlinson JL, Arnoczky SP, Fox DB, Cook CR, Kreeger JM“Kinetic study of the replacement of porcine small intestinal submucosa grafts and the regeneration of meniscal-like tissue in large avascular meniscal defects in dogs.” Tissue Engineering 2001;7:321-334.

Cook JL, Tomlinson JL, Kreeger JM, Cook C.“Induction of meniscal regeneration in dogs using a novel biomaterial.” American Journal of Sports Medicine 1999;27:658-665.

Crow BD, Haltom JD, Carson WL, Greene WB, Cook JL.“Evaluation of a novel biomaterial for intrasubstance muscle laceration repair.” Journal of Orthopaedic Research 2007;25:396-403.

Cunningham BW, Berven SH, Hu N, Beatson HJ, De Deyne PG, McAfee PC.“Regeneration of a spinal ligament after total lumbar disk arthroplasty in primates.” Cells, Tissues, and Organs 2009;190:347-355.

Daly K, Wolf MT, Johnson S, Badylak SF.“A rabbit model of peripheral compartment syndrome with associated rhabdomyolysis and a regenerative medicine approach for treatment.” Tissue Engineering Part C Methods 2011;17:631-640.

Dejardin LM, Arnoczky SP, Clarke RB.“Use of small intestinal submucosal implants for regeneration of large fascial defects: an experimental study in dogs.” Journal of Biomedical Materials Research 1999;46:203-211.

Dejardin LM, Arnoczky SP, Ewers BJ, Haut RC, Clarke RB.“Tissue-engineered rotator cuff tendon using porcine small intestine submucosa: Histologic and mechanical evaluation in dogs.” American Journal of Sports Medicine 2001;29:175-184.

Derwin K, Androjna C, Spencer E, Safran O, Bauer TW, Hunt T, Caplan A, Iannotti J.“Porcine small intestine submucosa as a flexor tendon graft.” Clinical Orthopaedics and Related Research 2004;423:245-252.

Fini M, Torricelli P, Giavaresi G, Rotini R, Castagna A, Giardino R.“In vitro study comparing two collageneous membranes in view of their clinical application for rotator cuff tendon regeneration.” Journal of Orthopaedic Research 2007;25:98-107.

Fox DB, Cook JL, Arnoczky SP, Tomlinson JL, Kuroko K, Kreeger JM, Malaviya P.“Fibrochondrogenesis of free intraarticular small intestinal submucosa scaffolds.” Tissue Engineering 2004;10:129-138.

Fox DB, Cook JL, Kuroki K, Cockrell M.“Effects of dynamic compressive load on collagen-based scaffolds seeded with fibroblast-like synoviocytes.” Tissue Engineering 2006;12:1527-1537.

Frisbie DD, Bowman SM, Colhoun HA, Dicarlo EF, Kawcak CE, McIlwraith CW.“Evaluation of autologous chondrocyte transplantation via a collagen membrane in equine articular defects - results at 12 and 18 months.” Osteoarthritis and Cartilage 2008;16:667-679.

Gastel JA, Muirhead WR, Lifrak JT, Fadale PD, Hulstyn MJ, Labrador DP.“Meniscal tissue regeneration using a collagenous biomaterial derived from porcine small intestine submucosa.” Arthroscopy: The Journal of Arthroscopic and Related Surgery 2001;17:151-159.

Gilbert TW, Stewart-Akers AM, Simmons-Byrd A, Badylak SF.“Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair.” Journal of Bone and Joint Surgery 2007;89:621-630.

Gu Y, Dai K.“[Substitution of porcine small intestinal submucosa for rabbit Achilles tendon, an experimental study].” Zhonghua Yi Xue Za Zhi 2002;82:1279-1282.

Iannotti JP, Codsi MJ, Kwon YW, Derwin K, Ciccone J, Brems JJ.“Porcine small intestine submucosa augmentation of surgical repair of chronic two-tendon rotator cuff tears. A randomized, controlled trial.” Journal of Bone and Joint Surgery 2006;88:1238-1244.

Jagodzinski M, Cebotari S, Tudorache I, Zeichen J, Hankemeier S, Krettek C, van Griensven M, Mertisching H.“Tissue engineering of long bones with a vascular matrix in a bioreactor.” Orthopade 2004;33:1394-1400.

Karaoglu S, B Fisher M, Woo SL, Fu YC, Liang R, Abramowitch SD.“Use of a bioscaffold to improve healing of a patellar tendon defect after graft harvest for ACL reconstruction: A study in rabbits.” Journal of Orthopaedic Research 2008;26:255-263.

Khang G, Rhee JM, Shin P, Kim IY, Lee B, Lee SJ, Lee YM, Lee HB, Lee I.“Preparation and characterization of small intestine submucosa powder impregnated poly(L-lactide) scaffolds: The application for tissue engineered bone and cartilage.” Macromolecular Research 2002;10:158-167.

Ledet EH, Carl AL, DiRisio DJ, Tymeson MP, Andersen LB, Sheehan CE, Kallakury B, Slivka M, Serhan H.“A pilot study to evaluate the effectiveness of small intestinal submucosa used to repair spinal ligaments in the goat.” Spine Journal 2002;2:188-196.

Ledet EH, Jeshuran W, Glennon JC, Shaffrey C, De Deyne P, Belden C, Kallakury B, Carl AL.“Small intestinal submucosa for anular defect closure: Long-term response in an in vivo sheep model.” Spine 2009;34:1457-1463.

Lee AJ, Chung WH, Kim DH, Lee KP, Chung DJ, Do SH, Kim HY.“Anterior cruciate ligament reconstruction in a rabbit model using canine small intestinal submucosa and autologous platelet-rich plasma.” Journal of Surgical Research 2012;206-215.

Liang R, Woo SL, Nguyen TD, Liu PC, Almarza A.“Effects of a bioscaffold on collagen fibrillogenesis in healing medial collateral ligament in rabbits.” Journal of Orthopaedic Research 2008;26:1098-1104.

Liang R, Woo SL, Takakura Y, Moon DK, Jia F, Abramowitch SD.“Long-term effects of porcine small intestine submucosa on the healing of medial collateral ligament: A functional tissue engineering study.” Journal of Orthopedic Research 2006;24:811-819.

Malcarney HL, Bonar F, Murrell GA.“Early inflammatory reaction after rotator cuff repair with a porcine small intestine submucosal implant.” American Journal of Sports Medicine 2005;33:907-911.

Metcalf MH. Savoie FH III. Kellum B.“Surgical technique for xenograft (SIS) augmentation of rotator-cuff repairs.” Operative Techniques in Orthopaedics 2002;12:204-208.

Moore DC, Pedrozo HA, Crisco JJ, Ehrlich MG.“Preformed grafts of porcine small intestine submucosa (SIS) for bridging segmental bone defects.” Journal of Biomedical Materials Research 2004;69A:259-266.

Murphy KD, Mushkudiani IA, Kao D, Levesque AY, Hawkins HK, Gould LJ.“Successful incorporation of tissue-engineered porcine small-intestinal submucosa as substitute flexor tendon graft is mediated by elevated TGF-beta1 expression in the rabbit.” Journal of Hand Surgery [Am] 2008;33:1168-1178.

Musahl V, Abramowitch SD, Gilbert TW, Tsuda E, Wang JH, Badylak SF, Woo SL.“The use of porcine small intestinal submucosa to enhance the healing of the medial collateral ligament - a functional tissue engineering study in rabbits.” Journal of Orthopaedic Research 2004;22:214-220.

Nguyen DT, Geel J, Schulze M, Raschke MJ, Woo SL, van Dijk CN, Blankevoort L.“Healing of the goat anterior cruciate ligament after a new suture repair technique and bioscaffold treatment.” Tissue Engineering Part A 2013;19:2292-2299.

Nicholson GP, Breur GJ, Sickle DV, Yao JQ, Kim J, Blanchard CR.“Evaluation of a cross-linked acellular porcine dermal patch for rotator cuff repair augmentation in an ovine model.” Journal of Shoulder and Elbow Surgery 2007;16:S184-S190.

Owen TJ, Lantz GC, Hiles MC, VanVleet J, Martin BR, Geddes LA.“Calcification potential of small intestinal submucosa in a rat subcutaneous model.” Journal of Surgical Research 1997;71:179-186.

Peel SA, Chen H, Renlund R, Badylak SF, Kandel RA.“Formation of a SIS-cartilage composite graft in vitro and its use in the repair of articular cartilage defects.” Tissue Engineering 1998;4:143-155.

Perry SM, Gupta RR, Kleunen JV, Ramsey ML, Soslowsky LJ, Glaser DL.“Use of small intestine submucosa in a rat model of acute and chronic rotator cuff tear.” Journal of Shoulder and Elbow Surgery 2007;16:S179-S183.

Phipatanakul WP, Petersen SA.“Porcine small intestine submucosa xenograft augmentation in repair of massive rotator cuff tears.” American Journal of Orthopedics 2009;38:572-575.

Schlegel TF, Hawkins RJ, Lewis CW, Motta T, Turner AS.“The effects of augmentation with swine small intestine submucosa on tendon healing under tension: Histologic and mechanical evaluations in sheep.” American Journal of Sports Medicine 2006;34:275-280.

Sclamberg SG, Tibone JE, Itamura JM, Kasraeian S.“Six-month magnetic resonance imaging follow-up of large and massive rotator cuff repairs reinforced with porcine small intestinal submucosa.” Journal of Shoulder and Elbow Surgery 2004;13:538-541.

Sicari BM, Agrawal V, Siu BF, Medberry CJ, Dearth CL, Turner NJ, Badylak SF.“A murine model of volumetric muscle loss and a regenerative medicine approach for tissue replacement.” Tissue Engineering Part A 2012;18:1941-1948.

Song HJ, Lan BS, Cheng B, Zhang KF, Yan HW, Wang WZ, Gao ZQ.“Treatment of early avascular necrosis of femoral head by small intestinal submucosal matrix with peripheral blood stem cells.” Transplantation Proceedings 2011;43:2027-2032.

Suckow MA, Hodde JP, Wolter WR, Hiles MC.“Repair of experimental Achilles tenotomy with porcine renal capsule material in a rat model.” Journal of Materials Science: Materials in Medicine 2007;18:1105-1110.

Suckow MA, Voytik SL, Terril LA, Badylak SF.“Enhanced bone regeneration using porcine small intestinal submucosa.” Journal of Investigative Surgery 1999;12:277-287.

Sun T, Yang Z, Xie H.“[Experimental study on constructing muscle tissue in rabbits with tissue engineering methods].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2005;19:364-368.

Tan B, Wei RQ, Tan MY, Luo JC, Deng L, Chen XH, Hou JL, Li XQ, Yang ZM, Xie HQ.“Extracellular matrix bioscaffolds for orthopaedic applications. A comparative histologic study.” Journal of Bone and Joint Surgery 2006;88:2673-2686.

Tan KK, Kaur G, Byrne CM, Young CJ, Wright C, Solomon MJ.“The effect of range of motion on remodeling of small intestinal submucosa (SIS) when used as an achilles tendon repair material in the rabbit.” Tissue Engineering 1997;3:27-37.

Turner NJ, Badylak JS, Weber DJ, Badylak SF.“Biologic scaffold remodeling in a dog model of complex musculoskeletal injury.” Journal of Surgical Research 2012;176:490-502.

Turner NJ, Yates AJ, Weber DJ, Qureshi IR, Beer Stolz D, Gilbert TW, Badylak SF.“Xenogeneic extracellular matrix as an inductive scaffold for regeneration of a functioning musculotendinous junction.” Tissue Engineering 2010;16:3309-3317.

Warnock JJ, Spina J, Bobe G, Duesterdieck-Zellmer KF, Ott J, Baltzer WI, Bay BK.“Culture of canine synoviocytes on porcine intestinal submucosa scaffolds as a strategy for meniscal tissue engineering for treatment of meniscal injury in dogs.” Veterinary Journal 2013 Nov 11. [Epub]

Welch JA, Montgomery RD, Lenz SD, Plouhar P, Shelton WR.“Evaluation of small-intestinal submucosa implants for repair of meniscal defects in dogs.” American Journal of Veterinary Research 2002;63:427-431.

Woo SL, Takakura Y, Liang R, Jia F, Moon DK.“Treatment with bioscaffold enhances the fibril morphology and the collagen composition of healing medial collateral ligament in rabbits.” Tissue Engineering 2006;12:159-166.

Zalavras CG, Gardocki R, Huang E, Stevanovic M, Hedman T, Tibone J.“Reconstruction of large rotator cuff tendon defects with porcine small intestinal submucosa in an animal model.” Journal of Shoulder and Elbow Surgery 2006;15:224-231.

Zantop T, Gilbert TW, Yoder MC, Badylak SF.“Extracellular matrix scaffolds are repopulated by bone marrow-derived cells in a mouse model of achilles tendon reconstruction.” Journal of Orthopaedic Research 2006;24:1299-1309.

Zhao L, Zhao J, Wang S, Wang J, Liu J.“Comparative study between tissue-engineered periosteum and structural allograft in rabbit critical-sized radial defect model.” Journal of Biomedical Materials Research 2011;97:1-9.

Zhao L, Zhao J, Wang S, Xia Y, Liu J, He J, Wang X.“Evaluation of immunocompatibility of tissue-engineered periosteum.” Biomedical Materials 2011;6(1):015005.

Zhao L, Zhao JL, Wan L, Wang SK.“The study of the feasibility of segmental bone defect repair with tissue- engineered bone membrane: a qualitative observation.” Strategies in Trauma and Limb Reconstruction 2008;3:57-64.

Plastic Surgery

References noted with a yellow highlight refer to human patients.

Ambro BT, Zimmerman J, Rosenthal M, Pribitkin EA. Nasal septal perforation repair with porcine small intestinal submucosa. Arch Facial Plast Surg. 2003;5(6):528-529.

Centeno RF. Surgisis acellular collagen matrix in aesthetic and reconstructive plastic surgery soft tissue applications. Clin Plast Surg. 2009;36(2):229-240, vii.

Ferguson RE, Jr., Pu LL. Repair of the abdominal donor-site fascial defect with small intestinal submucosa (Surgisis) after TRAM flap breast reconstruction. Annals of plastic surgery. 2007;58(1):95-98.

Gabriel A, Gollin G. Management of complicated gastroschisis with porcine small intestinal submucosa and negative pressure wound therapy. Journal of pediatric surgery. 2006;41(11):1836-1840.

Greywoode M, Hamilton M, Malhotra M, et al. Repair of Nasal Septal Perforation with Porcine Small Intestinal Submucosa Xenograft. Department of Otolaryngology - Head and Neck Surgery Faculty Papers. Paper 23. 2012.

Leventhal DD, Pribitkin EA. Static facial suspension with Surgisis ES (Enhanced Strength) sling. Laryngoscope. 2008;118(1):20-23.

Leventhal DD, Seymour PE, Pribitkin EA.“Treatment of nasolabial folds with porcine small intestinal submucosa.” Otolaryngololgy - Head and Neck Surgery 2008;139:857-858.

Macleod TM, Williams G, Sanders R, Green CJ.“Histological evaluation of Permacol as a subcutaneous implant over a 20-week period in the rat model.” British Journal of Plastic Surgery 2005;58:518-532.

Marra KG, Defail AJ, Clavijo-Alvarez JA, Badylak SF, Taieb A, Schipper B, Bennett J, Rubin JP.“FGF-2 enhances vascularization for adipose tissue engineering.” Plastic and Reconstructive Surgery 2008;121:1153-1164.

Parekh A, Mantle B, Banks J, Swarts JD, Badylak SF, Dohar JE, Hebda PA.“Repair of the tympanic membrane with urinary bladder matrix.” Laryngoscope 2009;119:1206-1213.

Pribitkin EA, Ambro BT, Bloeden E, O'Hara BJ.“Rabbit ear cartilage regeneration with a small intestinal submucosa graft.” Laryngoscope 2004;114:S1-S19.

Pu LL.“Small intestinal submucosa (Surgisis) as a bioactive prosthetic material for repair of abdominal wall fascial defect.” Plastic and Reconstructive Surgery 2005;115:2127-2131.

Rohleder NH, Loeffelbein DJ, Feistl W, Eddicks M, Wolff KD, Gulati A, Steinstraesser L, Kesting MR.“Repair of oronasal fistulae by interposition of multilayered amniotic membrane allograft.” Plastic and Reconstructive Surgery 2013;132:172-181.

Seymour PE, Krein HM, Leventhal DD, Brown DM, O'Hara B, Bilyk JR, Pribitkin EA.“Orbital floor reconstruction using porcine small intestinal submucosa.” Medical Science Monitor 2008;14:BR227-230.

Seymour PE, Leventhal DD, Pribitkin EA.“Lip augmentation with porcine small intestinal submucosa.” Archives of Facial Plastic Surgery 2008;10:30-33.

Spiegel JH, Kessler JL.“Tympanic membrane perforation repair with acellular porcine submucosa.” Otology and Neurotology 2005;26:563-566.

Spiegel JH. Egan TJ.“Porcine small intestine submucosa for soft tissue augmentation.” Dermatologic Surgery 2004;30:1486-1490.

Zhang F, Ji Y, Pickus EJ, Oswald T, Gui L, Lineaweaver WC.“Cartilage repair using porcine small intestinal submucosa in a rabbit model: A preliminary study.” Timisoara Medical Journal 2004;54:24-27.

Zhang F, Zhang J, Lin S, Oswald T, Sones W, Zhengwei C, Dorsett-Martin, W, Lineaweaver WC.“Small intestinal submucosa in abdominal wall repair after TRAM flap harvesting in a rat model.” Plastic and Reconstructive Surgery 2003;112:565-570.

Zhang F, Zhu C, Oswald T, Lei MP, Lineaweaver WC.“Porcine small intestinal submucosa as a carrier for skin flap prefabrication.” Annals of Plastic Surgery 2003;51:488-492.

Review

References noted with a yellow highlight refer to human patients.

Alberti C.“[Are there any news in bladder reconstructive surgery? Some remarks on the state of the art in animal research].” Minerva Urologie & Nefrologie 2001;53:195-200.

Amrute KV, Badlani GH.“The science behind biomaterials in female stress urinary incontinence surgery.” Scientific World Journal 2009;9:23-31.

Andrée B, Bär A, Haverich A, Hilfiker A.“Small intestinal submucosa segments as matrix for tissue engineering - Review.” Tissue Engineering Part B Reviews 2013;19:279-291.

Antoniou SA, Pointner R, Granderath FA.“Hiatal hernia repair with the use of biologic meshes: a literature review.” Surgical Laparoscopy and Percutaneous Techniques 2011;21:1-9.

Asfaw TS, Northington G.“Synthetic and biological graft materials: Biological concepts.” Seminars in Colon and Rectal Surgery 2009;20:112-117.

Bachman S, Ramshaw B.“Prosthetic material in ventral hernia repair: How do I choose?” Surgical Clinics of North America 2008;88:101-112.

Badylak S.“Extracellular matrix as a scaffold for tissue engineering in veterinary medicine: Applications to soft tissue healing.” Clinical Techniques in Equine Practice 2004;3:173-181.

Badylak SF, Freytes DO, Gilbert TW.“Extracellular matrix as a biological scaffold material: Structure and function.” Acta Biomaterialia 2009;5:1-13.

Badylak SF, Gilbert TW.“Immune response to biologic scaffold materials.” Seminars in Immunology 2008;20:109-116.

Badylak SF.“The extracellular matrix as a biologic scaffold material.” Biomaterials 2007;28:3587-3593.

Badylak SF.“Regenerative medicine and developmental biology: The role of the extracellular matrix.” Anatomical Record B: New Anatomy 2005;287B:36-41.

Badylak SF.“Xenogeneic extracellular matrix as a scaffold for tissue reconstruction.” Transplant Immunology 2004;12:367-377.

Badylak SF.“Small intestinal submucosa (SIS): a biomaterial conducive to smart tissue remodeling.” Tissue Engineering: Current Perspectives Bell E (ed). Burkhauser Publishers, Cambridge, MA 1993, pp. 179-189.

Beale EW, Hoxworth RE, Livingston EH, Trussler AP.“The role of biologic mesh in abdominal wall reconstruction: a systematic review of the current literature.” Anmerican Journal of Surgery 2012;204:510-517.

Bell E.“Strategy for the selection of scaffolds for tissue engineering.” Tissue Engineering 1995;1:163-179.

Bellón JM.“[Biological prostheses: indications and usefulness in the repair of abdominal wall defects.]” Cirugica Espanola 2008;83:283-289.

Bellows CF, Alder A, Helton WS.“Abdominal wall reconstruction using biological tissue grafts: present status and future opportunities.” Expert Review of Medical Devices 2006;3:657-675.

Bellows CF, Smith A, Hodde J, Hiles M.“Tissue engineering in abdominal wall surgery.” Minerva Chirurgica 2011;66:129-143.

Benders KE, Weeren PR, Badylak SF, Saris DB, Dhert WJ, Malda J.“Extracellular matrix scaffolds for cartilage and bone regeneration.” Trends in Biotechnology 2013;31:169-176.

Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF.“The basement membrane component of biologic scaffolds derived from extracellular matrix.” Tissue Engineering 2006;12:519-526.

Brown BN, Badylak SF.“Extracellular matrix as an inductive scaffold for functional tissue reconstruction.” Translational Research 2013 Nov 8. [Epub]

Butler CE.“The role of bioprosthetics in abdominal wall reconstruction” Clinics in Plastic Surgery 2006;33:199-211.

Butt HZ, Salem MK, Vijaynagar B, Chaudhri S, Singh B.“Perineal reconstruction after extra-levator abdominoperineal excision (eLAPE): a systematic review.” International Journal of Colorectal Disease 2013 Feb 26. [Epub]

Caudill P, Nyland J, Smith C, Yerasimides J, Lach J.“Sports hernias: A systematic literature review.” British Journal of Sports Medicine 2008;42:954-964.

Cirocchi R, Farinella E, La Mura F, Cattorini L, Rossetti B, Milani D, Ricci P, Covarelli P, Coccetta M, Noya G, Sciannameo F.“Fibrin glue in the treatment of anal fistula: A systematic review.” Annals of Surgical Innovation and Research 2009;3:12.

Cornwell KG, Landsman A, James KS.“Extracellular matrix biomaterials for soft tissue repair.” Clinics in Podiatric Medicine and Surgery 2009;26:507-523.

Costantini E, Lazzeri M, Porena M.“Managing complications after midurethral sling for stress urinary incontinence.” EAU-EBU Update Series 2007;5:232-240.

Dedecker F, Grynberg M, Staerman F.“[Small intestinal submucosa (SIS): prospects in urogenital surgery].” Progres en Urologie 2005;15:405-410.

Deeba S, Aziz O, Sains PS, Darzi A.“Fistula-in-ano: Advances in treatment.” American Journal of Surgery 2008;196:95-99.

Derwin KA, Badylak SF, Steinmann SP, Iannotti JP.“Extracellular matrix scaffold devices for rotator cuff repair.” Journal of Shoulder and Elbow Surgery 2010;19:467-476.

Ding H, Zhang C.“[Current development of basic research and clinical use of small intestinal submucosa].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2010;24:112-115.

Downey DM, Ali S, Saxe JM, Goldblatt MI, Dolan JP.“Gastrointestinal staple line reinforcement.” Surgical Techniques International 2007;16:55-60.

Dudukgian H, Abcarian H.“Why do we have so much trouble treating anal fistula?” World Journal of Gastroenterology 2011;17:3292-3296.

Eisenbud D, Huang NF, Luke S, Silberklang M.“Skin substitutes and wound healing: Current status and challenges.” Wounds 2004;16:2-17.

El-Hayek KM, Chand B.“Biologic prosthetic materials for hernia repairs.” Journal of Long-Term Effects of Medical Implants 2010;20:159-169.

Ellis CN.“Surgical management of anal fistulas: A review of the literature and a proposed treatment algorithm.” World Journal of Colorectal Surgery 2013;3(2):8.

Engelsman AF, van der Mei HC, Ploeg RJ, Busscher HJ.“The phenomenon of infection with abdominal wall reconstruction.” Biomaterials 2007;28:2314-2327.

Falke GF, Atala A“Reconstruccion de tejidos y organos utilizando ingenieria tisular.” Arch Argent Pediatr 2000;92:103-115.

Faramarzi-Roques R.“[Use of biological acellular biomaterials in urology].” Progres en Urologie 2003;13:385-393

Fonder MA, Lazarus GS, Cowan DA, Aronson-Cook B, Kohli AR, Mamelak AJ.“Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings.” Journal of the American Academy of Dermatology 2008;58:185-206.

Gazala S, Bedard E.“Surgisis mesh for tracheal reconstruction.” Annals of Thoracic Surgery 2012;93:2076-2077.

Goldberg SM, Tozer P, Phillips R, Buntzen S.“[Sphincter preserving surgery for transsphincteric anal fistulas.]” Ugeskrift for Laeger 2011;173:1053-1055.

Gomelsky A, Dmochowski RR.“Bladder neck pubovaginal slings.” Expert Review of Medical Devices 2005;2:327-340.

Granderath FA, Carlson MA, Champion JK, Szold A, Basso N, Pointner R, Frantzides CT.“Prosthetic closure of the esophageal hiatus in large hiatal hernia repair and laparoscopic antireflux surgery.” Surgical Endoscopy 2006;20:367-379.

Harth KC, Rosen MJ.“Major complications associated with xenograft biologic mesh implantation in abdominal wall reconstruction.” Surgical Innovation 2009;16:324-329.

Herbella FA, Patti MG, Del Grande JC.“Hiatal mesh repair--current status.” Surgical Laparoscopy, Endoscopy, and Percutaneous Techniques 2011;21:61-66.

Herschorn S.“The use of biological and synthetic materials in vaginal surgery for prolapse.” Current Opinion in Urology 2007;17:408-414.

Hiles M, Hodde J.“Tissue engineering a clinically useful extracellular matrix biomaterial.” International Urogynecology Journal 2006;17:S39-S43.

Hiles M, Levitsky S.“Interactive biomaterials: Taking surgery to the next level.” International Surgery 2005;90:S13-S20.

Hiles M, Nihsen E, Hodde J.“Biologics in fistula surgery: Parallels with chronic wounds.” Seminars in Colon & Rectal Surgery 2009;20:32-37.

Hiles M, Ritchie RD, Altizer AM.“Are biologic grafts effective for hernia repair? A systematic review of the literature.” Surgical Innovation 2009;16:26-37.

Hodde J, Hiles M.“Constructive soft tissue remodelling with a biologic extracellular matrix graft: overview and review of the clinical literature.” Acta Chirugica Belgica 2007;107:641-647.

Hodde J.“Naturally-occurring scaffolds for soft tissue repair and regeneration.” Tissue Engineering 2002;8:295-308.

Hodde JP, Allam R.“Extracellular wound matrices: Small intestinal submucosa wound matrix for chronic wound healing.” Wounds 2007;19:157-162.

Hodde JP, Johnson CE.“Extracellular matrix as a strategy for treating chronic wounds.” American Journal of Clinical Dermatology 2007;8:61-66.

Hodde JP.“Extracellular matrix as a bioactive material for soft tissue reconstruction.” ANZ Journal of Surgery 2006;76:1096-1100.

Jalkut M, Gonzalez-Cadavid N, Rajfer J.“Peyronie's Disease: A Review.” Reviews in Urology 2003;5:142-148.

Jankowski R, Pruchnic R, Hiles M, Chancellor MB.“Advances toward tissue engineering for the treatment of stress urinary incontinence.” Reviews in Urology 2004;6:51-57.

Kadioglu A, Küçükdurmaz F, Sanli O.“Current status of the surgical management of Peyronie's disease.” Nature Reviews. Urology 2011;8:95-106.

Kadioglu A, Sanli O, Akman T, Ersay A, Guven S, Mammadov F.“Graft materials in Peyronie's disease surgery: a comprehensive review.” Journal of Sexual Medicine 2007;4:581-595.

Kania D.“Minimally invasive surgical technique in the management of perianal fistulas using the Surgisis® AFP material.” Polski Przeglad Chirurgiczny 2011;83:392-402.

Kissane NA, Itani KM.“A decade of ventral incisional hernia repairs with biologic acellular dermal matrix: what have we learned?” Plastic and Reconstructive Surgery 2012;130:194S-202S.

Klopsch C, Steinhoff G.“Tissue-engineered devices in cardiovascular surgery.” European Surgical Research 2012;49:44-52.

Kobashi KC, Hsiao KC, Govier FE.“Suitability of different sling materials for the treatment of female stress urinary incontinence.” Nature Clinical Practice Urology 2005;2:84-91.

Langer R, Vacanti JP, Vacanti CA, Atala A, Freed LE, Vunjak-Novakovic G“Tissue Engineering: Biomedical Applications.” Tissue Engineering 1995;1:151-161.

Le TH, Kon L, Bhatia NN, Ostergard DR.“Update on the utilization of grafts in pelvic reconstruction surgeries.” Current Opinion in Obstetrics and Gynecology 2007;19:480-489.

Leng Q, Jin HY.“Anal fistula plug vs mucosa advancement flap in complex fistula-in-ano: A meta-analysis.” World Journal of Gastrointestinal Surgery 2012;4:256-261.

Lin HK, Godiwalla SY, Palmer BW, Frimberger D, Yang Q, Madihally SV, Fung KM, Kropp B.“Understanding roles of porcine small intestinal submucosa (SIS) in urinary bladder regeneration: Identification of variable regenerative characteristics of SIS.” Tissue Engineering Part B: Reviews 2013 Jun 19. [Epub]

Londono R, Jobe BA, Hoppo T, Badylak SF.“Esophagus and regenerative medicine.” World Journal of Gastroenterology 2012;18:6894-6899.

Meintjes J, Yan S, Zhou L, Zheng S, Zheng M.“Synthetic, biological and composite scaffolds for abdominal wall reconstruction.” Expert Review of Medical Devices 2011;8:275-288.

Novitsky YW, Harrell AG, Hope WM, Kercher KW, Heniford BT.“Meshes in hernia repair.” Surgical Techniques International 2007;16:123-127.

O'Riordan JM, Datta I, Johnston C, Baxter NN.“A systematic review of the anal fistula plug for patients with Crohn's and non-Crohn's related fistula-in-ano.” Diseases of the Colon & Rectum 2012;55:351-358.

Papanas N, Eleftheriadou I, Tentolouris N, Maltezos E.“Advances in the topical treatment of diabetic foot ulcers.” Current Diabetes Reviews 2012;8:209-218.

Parekh A, Weaver A.“Regulation of cancer invasiveness by the physical extracellular matrix environment.” Cell Adhesion & Migration 2009;3:288-292.

Plotner AN, Mostow EN.“A review of bioactive materials and chronic wounds.” Cutis 2010;85:259-266.

Reid R.“Recto-enterocoele repair: Past problems and new horizons.” Pelviperineology 2007;26:9-16.

Ritchie RD, Sackier JM, Hodde JP.“Incontinence rates after cutting seton treatment for anal fistula.” Colorectal Disease 2009;11:564-571.

Ritchie RD, Sackier JM, Hodde JP.“Incontinence rates after cutting seton treatment for anal fistula.” Colorectal Disease 2008 Oct 20. [Epub]

Santucci RA, Barber TD.“Resorbable extracellular matrix grafts in urologic reconstruction.” International Brazilian Journal of Urology 2005;31:192-203.

Shawki S, Wexner SD.“Idiopathic fistula-in-ano.” World Journal of Gastroenterology 2011;17:3277-3285.

Shi L, Ronfard V.“Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review.” International Journal of Burns and Trauma 2013;3:173-179.

Slater NJ, van der Kolk M, Hendriks T, van Goor H, Bleichrodt RP.“Biologic grafts for ventral hernia repair: a systematic review.” American Journal of Surgery 2013;205:220-230.

Smart NJ, Marshall M, Daniels IR.“Biological meshes: A review of their use in abdominal wall hernia repairs.” Surgeon 2012;10:159-171.

Song KH.“New techniques for treating an anal fistula.” Journal of the Korean Society of Coloproctology 2012;28:7-12.

Spievack AR.“Experience with porcine acellular dermis.” World Journal of Surgery 2007;31:1973-1974.

Staack A, Hayward SW, Baskin LS, Cunha GR.“Molecular, cellular and developmental biology of urothelium as a basis of bladder regeneration.” Differentiation 2005;73:121-133.

Stein SL, Michelassi F.“New advances in surgical management of Crohn's disease.” Practical Gastroenterology 2008;32:35-40.

Stock UA, Vacanti J.“Tissue Engineering: Current state and prospects.” Annual Reviews Medicine 2001;52:443-451.

Suckow MA, Ritchie R, Overby A.“Extracellular matrix adjuvant for vaccines.” Biomaterials Applications for Nanomedicine. Pignatello R (ed). InTech - Open Access Publisher, Rijeka, Croatia 2011, pp. 441-458.

Tornehl CK, Carson CC.“Surgical alternatives for treating Peyronie's disease.” BJU International 2004;94:774-783.

Trabuco EC, Klingele CJ, Gebhart JB.“Xenograft use in reconstructive pelvic surgery: a review of the literature.” International Urogynecology Journal 2007;18:555-563.

Turner NJ, Badylak SF.“Biologic scaffolds for musculotendinous tissue repair.” European Cells and Materials 2013;25:130-143.

van Koperen PJ, Horsthuis K, Bemelman WA, Stoker J, Slors JF.“[Perianal fistulas: developments in the classification and diagnostic techniques, and a new treatment strategy].” Nederlands Tijdschrift voor Geneeskunde 2008;152:2774-2780.

Vieller GR.“Innovations in ventral hernia repair.” Surgical Techniques International 2007;16:117-122.

Woo SL, Fisher MB, Feola AJ.“Contribution of biomechanics to management of ligament and tendon injuries.” Molecular and Cellular Biomechanics 2008;5:49-68.

Woo SL.“Tissue engineering: Use of scaffolds for ligament and tendon healing and regeneration.” Knee Surgery, Sports Traumatology, Arthroscopy 2009;17:559-560.

Yang K, Zhang Y, Zhang N, Xu W, Li B.“[Recent progress of small intestinal submucosa in application research of tissue repair and reconstruction].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2013;27:1138-1143.

Yo LS, Consten EC, Quarles van Ufford HM, Gooszen HG, Gagner M.“Buttressing of the staple line in gastrointestinal anastomoses: Overview of new technology designed to reduce perioperative complications.” Digestive Surgery 2006;23:283-291.

Zehetner J, Demeester SR, Ayazi S, Kilday P, Augustin F, Hagen JA, Lipham JC, Sohn HJ, Demeester TR.“Laparoscopic versus open repair of paraesophageal hernia: the second decade.” Journal of the American College of Surgery 2011;212:813-820.

Thoracic

References noted with a yellow highlight refer to human patients.

Downey DM, Harre JG, Pratt JW.“Functional comparison of staple line reinforcements in lung resection.” Annals of Thoracic Surgery 2006;82:1880-1883.

Downey DM, Michel M, Harre JG, Pratt JW.“Functional assessment of a new staple line reinforcement in lung resection.” Journal of Surgical Research 2006;131:49-52.

Fuchs JR, Kaviani A, Oh JT, Lavan D, Udagawa T, Jennings RW, Wilson JM, Fauza DO.“Diaphragmatic reconstruction with autologous tendon engineered from mesenchymal amniocytes.” Journal of Pediatric Surgery 2004;39:834-838.

Gilbert TW, Gilbert S, Madden M, Reynolds SD, Badylak SF.“Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model.” Annals of Thoracic Surgery 2008;86:967-974.

Gilbert TW, Nieponice A, Spievack AR, Holcomb J, Gilbert S, Badylak SF.“Repair of the thoracic wall with an extracellular matrix scaffold in a canine model.” Journal of Surgical Research 2008;147:61-67.

Keckler SJ, Spilde TL, St Peter SD, Tsao K, Ostlie DJ.“Treatment of bronchopleural fistula with small intestinal mucosa and fibrin glue sealant.” Annals of Thoracic Surgery 2007;84:1383-1386.

Murphy F, Corbally MT.“The novel use of small intestinal submucosal matrix for chest wall reconstruction following Ewing's tumour resection.” Pediatric Surgery International 2007;23:353-356.

Oliveira C, Zamakhshary M, Alfadda T, Alhabshan F, Alshalaan H, Miller S, Kim PC.“An innovative method of pediatric chest wall reconstruction using Surgisis and swinging rib technique.” Journal of Pediatric Surgery 2012;47:867-873.

Paul S, Talbot SG, Carty M, Orgill DP, Zellos L.“Bronchopleural fistula repair during Clagett closure utilizing a collagen matrix plug.” Annals of Thoracic Surgery 2007;83:1519-1521.

Smith MD, Campbell RM.“Use of a biodegradable patch for reconstruction of large thoracic cage defects in growing children.” Journal of Pediatric Surgery 2006;41:46-49.

Yeen WC, Faber C, Caldeira C, Nallamshetty L, Haddad T, Rolfe M.“Reconstruction of pulmonary venous conduit with CorMatrix in lung transplant. ” Asian Cardiovascular & Thoracic Annals 2013;21:360-362.

Yeen WC, Faber C, Caldeira C, Nallamshetty L, Haddad T, Rolfe M.“Reconstruction of pulmonary venous conduit with CorMatrix in lung transplant. ” Asian Cardiovascular & Thoracic Annals 2013;21:360-362.

Urology

References noted with a yellow highlight refer to human patients.

Alberti C.“[From the intestinal neobladder to the bioartificial bladder: Remarks on some biological implications].” Minerva Urologie & Nefrologie 2000;52:219-222.

Alpert SA, Cheng EY, Kaplan WE, Snodgrass WT, Wilcox DT, Kropp BP.“Bladder neck fistula after the complete primary repair of exstrophy: a multi-institutional experience.” Journal of Urology 2005;174:1687-1690.

Ashley RA, Palmer BW, Schultz AD, Woodson BW, Roth CC, Routh JC, Fung KM, Frimberger D, Lin HK, Kropp B.“Leukocyte inflammatory response in a rat urinary bladder regeneration model using porcine small intestinal submucosa scaffold.” Tissue Engineering 2009:15;3241-3246.

Ashley RA, Roth CC, Palmer BW, Kibar Y, Routh JC, Fung KM, Frimberger D, Lin HK, Kropp BP.“Regional variations in small intestinal submucosa evoke differences in inflammation with subsequent impact on tissue regeneration in the rat bladder augmentation model.” BJU International 2010;105:1462-1468.

Ayyildiz A, Akgül KT, Huri E, Nuho?lu B, Kiliço?lu B, Ustün H, Gürdal M, Germiyano?lu C.“Use of porcine small intestinal submucosa in bladder augmentation in rabbit: long-term histological outcome.” ANZ Journal of Surgery 2008;78:82-86.

Badylak SF, Kropp B, McPherson T, Liang H, Snyder PW.“Small intestinal submucosa: A rapidly resorbed bioscaffold for augmentation cystoplasty in a dog model.” Tissue Engineering 1998;4:379-387.

Baumert H, Hekmati M, Dunia I, Mansouri D, Massoud W, Molinié V, Benedetti EL, Malavaud B.“Laparoscopy in ureteral engineering: A feasibility study.” European Urology 2008;54:1154-1163.

Baumert H, Mansouri D, Fromont G, Hekmati M, Simon P, Massoud W, Molinie V, Malavaud B.“Terminal urothelium differentiation of engineered neoureter after in vivo maturation in the 'Omental Bioreactor'.” European Urology 2007;52:1492-1498.

Baumert H, Simon P, Hekmati M, Fromont G, Levy M, Balaton A, Molinie V, Malavaud B.“Development of a seeded scaffold in the great omentum: Feasibility of an in vivo bioreactor for bladder tissue engineering.” European Urology 2007;52:884-892.

Beintker M, Vogt B, Schubert J, Schubert H, Kosmehl H.“[Urethroplasty with tissue matrix : Microsurgical animal experiments with small intestinal submucosa.]” Urologe A. 2007;46:1236-1237.

Boruch AV, Nieponice A, Qureshi IR, Gilbert TW, Badylak SF.“Constructive remodeling of biologic scaffolds is dependent on early exposure to physiologic bladder filling in a canine partial cystectomy model.” Journal of Surgical Research 2010;161:217-225.

Braga LH, Pippi Salle JL, Dave S, Bagli DJ, Lorenzo AJ, Khoury AE.“Outcome analysis of severe chordee correction using tunica vaginalis as a flap in boys with proximal hypospadias.” Journal of Urology 2007;178:1693-1697.

Breyer BN, Brant WO, Garcia MM, Bella AJ, Lue TF.“Complications of porcine small intestine submucosa graft for Peyronie's disease.” Journal of Urology 2007;177:589-591.

Caione P, Boldrini R, Salerno A, Nappo SG.“Bladder augmentation using acellular collagen biomatrix: a pilot experience in exstrophic patients.” Pediatric Surgery International 2012;28:421-428.

Caione P, Capozza N, Zavaglia D, Palombaro G, Boldrini R.“In vivo bladder regeneration using small intestinal submucosa: experimental study.” Pediatric Surgery International 2006;22:593-599.

Calvano CJ, Moran ME, Parekh A, Desai PJ, Cisek LJ.“Laparoscopic augmentation cystoplasty using the novel biomaterial Surgisis: small-intestinal submucosa.” Journal of Endourology 2000;14:213-217.

Campodonico F, Benelli R, Michelazzi A, Ognio E, Toncini C, Maffezzini M.“Bladder cell culture on small intestinal submucosa as bioscaffold: experimental study on engineered urothelial grafts.” European Urology 2004;46:531-537.

Cheng EY, Kropp BP.“Urologic tissue engineering with small-intestinal submucosa: potential clinical applications.” World Journal of Urology 2000;18:26-30.

Chung E, Clendinning E, Lessard L, Brock G.“Five-year follow-up of Peyronie's graft surgery: Outcomes and patient satisfaction.” Journal of Sexual Medicine 2011;8:594-600.

Chung SY, Krivorov NP, Rausei V, Thomas L, Frantzen M, Landsittel D, Kang YM, Chon CH, Ng CS, Fuchs GJ.“Bladder reconstitution with bone marrow derived stem cells seeded on small intestinal submucosa improves morphological and molecular composition.” Journal of Urology 2005;174:353-359.

Chung YG, Tu D, Franck D, Gil ES, Algarrahi K, Adam RM, Kaplan DL, Estrada CR Jr, Mauney JR.“Acellular bi-layer silk fibroin scaffolds support tissue regeneration in a rabbit model of onlay urethroplasty.” PloS One 2014;9:e91592.

de Almeida SH, Rodrigues MA, Gregório E, Crespígio J, Moreira HA.“Influence of sling material on inflammation and collagen deposit in an animal model.” International Journal of Urology 2007-14:1040-1043.

Desgrandchamps F.“Biomaterials in functional reconstruction.” Current Opinion in Urology 2000;10:201-206.

Donkov II, Bashir A, Elenkov CH, Panchev PK.“Dorsal onlay augmentation urethroplasty with small intestinal submucosa: Modified Barbagli technique for strictures of the bulbar urethra.” International Journal of Urology 2006;13:1415-1417.

Drewa T.“The artificial conduit for urinary diversion in rats: a preliminary study.” Transplant Proceedings 2007;39:1647-1651.

Duchene DA, Jacomides L, Ogan K, Lindberg G, Johnson BD, Pearle MS, Cadeddu JA.“Ureteral replacement using small-intestinal submucosa and a collagen inhibitor in a porcine model.” Journal of Endourology 2004;18:507-511.

Ecke TH, Hallmann S, Gerullis H, Ruttloff J.“Reconstruction of the urethra with a Surgisis® onlay patch in urethral reconstructive surgery: Two case reports.” Journal of Medical Case Reports 2009;3:6542.

El-Assmy A, El-Hamid MA, Abo-Elghar ME, Hafez AT.“Single-layer small intestinal submucosa or tunica vaginalis flap for correcting penile chordee.” BJU International 2004;94:1097-1101.

El-Assmy A, El-Hamid MA, Hafez AT.“Urethral replacement: a comparison between small intestinal submucosa grafts and spontaneous regeneration.” BJU International 2004;94:1132-1135.

El-Assmy A, Hafez AT, El-Sherbiny MT, El-Hamid MA, Mohsen T, Nour EM, Bazeed M“Use of single layer small intestinal submucosa for long segment ureteral replacement: A pilot study.” Journal of Urology 2004;171:1939-1942.

El-Hakim A, Marcovich R, Chiu KY, Lee BR, Smith AD.“First prize: Ureteral segmental replacement revisited.” Journal of Endourology 2005;19:1069-1074.

Elbahnasy AM, Shalhav A, Hoenig DM, Figenshau R, Clayman RV.“Bladder wall substitution with synthetic and nonintestinal organic materials.” Journal of Urology 1998;159:628-637.

Elmore JM, Kirsch AJ, Scherz HC, Smith EA.“Small intestinal submucosa for corporeal body grafting in severe hypospadias requiring division of the urethral plate.” Journal of Urology 2007;178:1698-1701.

Farahat Y, Eltatawy H, Haroun H, Abo-Ramadan A, Morad S, Rasheed M.“The small intestinal submucosa (SIS) as a suburethral sling for correction of stress urinary incontinence: Preliminary experience.” UroToday International Journal 2009;2(3).

Farahat YA, Elbahnasy AM, El-Gamal OM, Ramadan AR, El-Abd SA, Taha MR.“Endoscopic urethroplasty using small intestinal submucosal patch in cases of recurrent urethral stricture: a preliminary study.” Journal of Endourology 2009;23:2001-2005.

Faramarzi-Roques R, Malgat M, Desgrandchamps F, Ballanger P, Mazat JP.“Mitochondrial metabolism in the rat during bladder regeneration induced by small intestinal submucosa.” BJU International 2004;94:419-423.

Fiala R, Vidlar A, Vrtal R, Belej K, Student V.“Porcine small intestinal submucosa graft for repair of anterior urethral strictures.” European Urology 2007;51:1702-1708.

Flores S, Choi J, Alex B, Mulhall JP.“Erectile dysfunction after plaque incision and grafting: short-term assessment of incidence and predictors.” Journal of Sexual Medicine 2011;8:2031-2037.

Frederiksen H, Davidsson T, Gabella G, Uvelius B.“Nerve distribution in rat urinary bladder after incorporation of acellular matrix graft or subtotal cystectomy.” Scandanavian Journal of Urology and Nephrology 2008;42:205-212.

Frimberger D, Morales N, Shamblott M, Gearhart JD, Gearhart JP, Lakshmanan Y.“Human embryoid body-derived stem cells in bladder regeneration using rodent model.” Urology 2005;65:827-832.

Furness PD, Kolligian ME, Lang SJ, Kaplan WE, Kropp BP, Cheng EY.“Injectable small intestinal submucosa: preliminary evaluation for use in endoscopic urological surgery.” Journal of Urology 2000;164:1680-1685.

Gabouev AI, Schultheiss D, Mertsching H, Koppe M, Schlote N, Wefer J, Jonas U, Stief CG.“In vitro construction of urinary bladder wall using porcine primary cells reseeded on acellularized bladder matrix and small intestinal submucosa.” International Journal of Artificial Organs 2003;26:935-942.

Greca FH, Noronha L, Bendhack M, Feres A, Soccol A, Duda JR.“Use of small intestine submucosa as ureteral allograft in pigs.” International Brazilian Journal of Urology 2004;30:327-335.

Grossklaus DJ, Shappell SB, Adams MC, Brock JW, Pope JC.“Small intestinal submucosa as a urethral coverage layer.” Journal of Urology 2001;166:636-639.

Gulino G, Falabella R, Gentile G, Sasso F.“[Radical surgery in Peyronie's disease. Graft comparison].” Minerva Chirugica 2002;57:383-388.

Hafez AT, El-Assmy A, El-Hamid MA.“4 layer versus 1 layer small intestinal submucosa for correction of penile chordee: experimental study in a rabbit model.” Journal of Urology 2004;171:2489-2491.

Han P, Luo JC, Zhi W, Tan B, Li XQ, Yang ZM.“[Constructing tissue-engineered urothelial structures in vitro and in vivo].” Sichuan Da Xue Xue Bao Yi Xue Ban 2008;39:481-484, 510.

Hauser S, Bastian PJ, Fechner G, Muller SC.“Small intestine submucosa in urethral stricture repair in a consecutive series.” Urology 2006;68:263-266.

Hayn MH, Bellinger MF, Schneck FX.“Small intestine submucosa as a corporal body graft in the repair of severe chordee.” Urology 2009;73:277-279.

Huang X, Luo J, Liao Y, Qu Y, Yang Z.“[Study on small intestinal submucosa as repair materials in urethral reconstruction].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006;20:206-209.

Iijima K, Igawa Y, Imamura T, Moriizumi T, Nikaido T, Konishi I, Nishizawa O.“Transplantation of preserved human amniotic membrane for bladder augmentation in rats.” Tissue Engineering 2007;13:513-524.

Jaffe JS, Ginsberg PC, Yanoshak SJ, Costa LE, Ogbolu FN, Moyer CP, Greene CH, Finkelstein LH, Harkaway RC.“Ureteral segment replacement using a circumferential small-intestinal submucosa xenogenic graft.” Journal of Investigative Surgery 2001;14:259-265.

John T, Bandi G, Santucci R.“ Porcine small intestinal submucosa is not an ideal graft material for Peyronie's disease surgery.” Journal of Urology 2006;176:1025-1029.

Jones JS, Rackley RR, Berglund R, Abdelmalak JB, Deorco G, Vasavada SP.“Porcine small intestinal submucosa as a percutaneous mid-urethral sling: 2-year results.” BJU International 2005;96:103-106.

Jones JS, Vasavada SP, Abdelmalak JB, Liou L, Ahmed ES, Zippe CD, Rackley RR.“Sling may hasten return of continence after radical prostatectomy.” Urology 2005;65:1163-1167.

Kakizawa H, Conlin MJ, Pavcnik D, Uchida BT, Loriaux M, Kim YH, Keller FS, Rösch J.“Small intestinal submucosa plug for closure of dilated nephrostomy tracts: a pilot study in swine.” Cardiovascular and Interventional Radiology 2010;33:596-600.

Kawano PR, Fugita OE, Yamamoto HA, Quitzan JG, Padovani C, Amaro JL.“Comparative study between porcine small intestinal submucosa and buccal mucosa in a partial urethra substitution in rabbits.” Journal of Endourology 2012;26:427-432.

Kim BS, Baez CE, Atala A.“Biomaterials for tissue engineering.” World Journal of Urology 2000;18:2-9.

Knapp PM, Lingeman JE, Siegel YI, Badylak SF, Demeter RJ.“Biocompatibility of small-intestinal submucosa in urinary tract as augmentation cystoplasty graft and injectable suspension.” Journal of Endourology 1994;8:125-130.

Knoll LD.“Use of Small intestinal submucosa graft for the surgical management of Peyronie's Disease.” Journal of Urology 2007;178:2474-2478.

Knoll LD.“Use of porcine small intestinal submucosal graft in the surgical management of Peyronie's disease.” Current Clinical Urology: Peyronie's Disease: A Guide to Clinical Management. 2006, pp. 209-216.

Knoll LD.“Use of porcine small intestinal submucosal graft in the surgical management of tunical deficiencies with penile prosthetic surgery.” Urology 2002;59:758-761.

Knoll LD.“Use of porcine small intestinal submucosal graft in the surgical management of Peyronie's Disease.” Urology 2001;57:753-757.

Krambeck AE, Dora CD, Sebo TJ, Rohlinger AL, DiMarco DS, Elliott DS.“Time-dependent variations in inflammation and scar formation of six different pubovaginal sling materials in the rabbit model.” Urology 2006;67:1105-1110.

Kropp BP, Badylak S, Thor KB.“Regenerative bladder augmentation: a review of the initial preclinical studies with porcine small intestinal submucosa.” Advances in Experimental Medicine & Biology 1995;385:229-235.

Kropp BP, Cheng EY, Lin HK, Zhang Y.“Reliable and reproducible bladder regeneration using unseeded distal small intestinal submucosa.” Journal of Urology 2004;172:1710-1713.

Kropp BP, Cheng EY, Pope JC, Brock JW, Koyle MA, Furness PD, Weigel ND, Keck RW, Kropp KA.“Use of small intestinal submucosa for corporal body grafting in cases of severe penile curvature.” Journal of Urology 2002;168:1742-1745.

Kropp BP, Cheng EY.“Bioengineering organs using small intestinal submucosa scaffolds: in vivo tissue-engineering technology.” Journal of Endourology 2000;14:59-62.

Kropp BP, Eppley BL, Prevel CD, Rippy MK, Harruff RC, Badylak SF, Adams MC, Rink RC, Keating MA.“Experimental assessment of small intestinal submucosa as a bladder wall substitute.” Urology 1995;46:396-400.

Kropp BP, Ludlow JK, Spicer D, Rippy MK, Badylak SF, Adams MC, Keating MA, Rink RC, Birhle R, Thor KB.“Rabbit urethral regeneration using small intestinal submucosa onlay grafts.” Urology 1998;52:138-142.

Kropp BP, Pope JC.“Small intestinal submucosa: A novel substance for the study of cellular interaction and regeneration in the bladder.” Dialogues in Pediatric Urology 1997;20:1-8.

Kropp BP, Rippy MK, Badylak SF, Adams MC, Keating MA, Rink RC, Thor KB.“Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment in long-term canine bladder augmentations.” Journal of Urology 1996;155:2098-2104.

Kropp BP, Sawyer BD, Shannon HE, Rippy MK, Badylak SF, Adams MC, Keating MA, Rink RC, Thor KB.“Characterization of small intestinal submucosa regenerated canine detrusor: Assessment of reinnervation, in vitro compliance and contractility.” Journal of Urology 1996;156:599-607.

Kropp BP.“Developmental aspects of the contractile smooth muscle component in small intestinal submucosa regenerated urinary bladder.” Advances in Bladder Research 1999;462:129-135.

Kropp BP.“Small-intestinal submucosa for bladder augmentation: a review of preclinical studies.” World Journal of Urology 1998;16:262-267.

Kubricht WS 3rd, Williams BJ, Eastham JA, Venable DD.“Tensile strength of cadaveric fascia lata compared to small intestinal submucosa using suture pull through analysis.” Journal of Urology 2001;165:486-490.

Lai JY, Chang PY, Lin JN.“Bladder autoaugmentation using various biodegradable scaffolds seeded with autologous smooth muscle cells in a rabbit model.” Journal of Pediatric Surgery 2005;40:1869-1873.

Landman J, Olweny E, Collyer W, Andreoni C, Carlin B, Yan Y, Clayman RV.“Small intestine submucosa: intrinsic and asastomotic tensile strength of SIS using laser welding, fibrin glue, vascular closure staples, endo-GIA staples and sutures.” Minimally Invasive Therapy & Allied Technology 2000;9:375-378.

Landman J, Olweny E, Sundaram CP, Andreoni C, Collyer WC, Rehman J, Jerde TJ, Lin HK, Lee DI, Nunlist EH, Humphrey PA, Nakada SY, Clayman RV.“Laparoscopic mid sagittal hemicystectomy and bladder reconstruction with small intestinal submucosa and reimplantation of ureter into small intestinal submucosa: 1-year followup.” Journal of Urology 2004;171:2450-2455.

le Roux PJ.“Endoscopic urethroplasty with unseeded small intestinal submucosa collagen matrix grafts: a pilot study.” Journal of Urology 2005;173:140-143.

Lee EW, Shindel AW, Brandes SB.“Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's disease.” International Brazilian Journal of Urology 2008;34:191-197.

Leslie JA, Cain MP, Kaefer M, Meldrum KK, Misseri R, Rink RC.“Corporeal grafting for severe hypospadias: A single institution experience with 3 techniques.” Journal of Urology 2008;180:1749-1752.

Leungwattanakij S, Pummangura N, Ratana-Olarn K.“Penile enhancement using a porcine small intestinal submucosa graft in a rat model.” International Journal of Impotence Research 2006;18:39-43.

Liatsikos EN, Dinlenc CZ, Kapoor R, Alexianu M, Yohannes P, Anderson AE, Smith AD.“Laparoscopic ureteral reconstruction with small intestinal submucosa.” Journal of Endourology 2001;15:217-220.

Liatsikos EN, Dinlenc CZ, Kapoor R, Bernardo NO, Pikhasov D, Anderson AE, Smith AD.“Ureteral reconstruction: Small intestinal submucosa for the management of strictures and defects of the upper third of the ureter.” Journal of Urology 2001;165:1719-1723.

Lu HK, Ren AJ, Sun XL, Gao EJ, Yu ZY, Yan B.“[Compound graft of porcine small intestinal submucosa with Schwann cells to reconstruct injured cavernous nerves and restore erectile function].” Zhonghua Nan Ke Xue 2010;16:834-9.

Lu HK, Zhou HJ, Gao EJ, Song LJ, Zuo HZ, Yan B, Yu ZY, Du J, Bi WH.“[Restoration of erectile function by reconstructing cavernous nerves with small intestinal submucosa grafts].” Zhonghua Nan Ke Xue 2010;16:150-153.

Ma L, Yang Y, Sikka SC, Kadowitz PJ, Ignarro LJ, Abdel-Mageed AB, Hellstrom WJG.“Adipose tissue-derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction.” Proceedings of the Nationals Academy of Sciences 2012;109:2090-2095.

Magunna, C, Spellmeyer, O, Hund M, Nickel R.“[Bladder augmentation after radical resection using porcine small intestinal submucosa (SIS): first results of the clinical application as a xenograft in the dog and cat].” Kleintierpraxis 1999;44:809-821.

Mantovani F, Tondelli E, Cozzi G, Abed el Rahman D, Spinelli MG, Oliva I, Finkelberg E, Talso M, Varisco D, Maggioni A, Rocco F.“[Reconstructive urethroplasty using porcine acellular matrix (SIS): evolution of the grafting technique and results of 10-year experience].” Urologica 2011;78:92-97.

Mantovani F, Trinchieri A, Castelnuovo C, Romano AL, Pisani E.“Reconstructive urethroplasty using porcine acellular matrix.” European Urology 2003;44:600-602.

Mantovani F, Trinchieri A, Mangiarotti B, Nicola M, Castelnuovo C, Confalonieri S, Pisani E.“Reconstructive urethroplasty using porcine acellular matrix: preliminary results.” Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica / Associazione ricerche in uro 2002;74:127-128.

Mauney JR, Cannon GM, Lovett ML, Gong EM, Di Vizio D, Gomez P 3rd, Kaplan DL, Adam RM, Estrada CR Jr.“Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation.” Biomaterials 2011;32:808-818.

Metwalli AR, Colvert JR, Kropp BP.“Tissue Engineering in urology: Where are we going?” Current Urology Reports 2003;4:156-163.

Miguel C, Rafael G, Joshi D, Yuval BY, Andrew L.“Ventral corporal body grafting for correcting severe penile curvature associated with single or two-stage hypospadias repair.” Journal of Pediatric Urology 2011;7:289-293.

Mondalek FG, Ashley RA, Roth CC, Kibar Y, Shakir N, Ihnat MA, Fung KM, Grady BP, Kropp BP, Lin HK.“Enhanced angiogenesis of modified porcine small intestinal submucosa with hyaluronic acid-poly(lactide-co-glycolide) nanoparticles: From fabrication topreclinical validation.” Journal of Biomedical Materials Research 2010;94:712-719.

Monga M, Cosgrove D, Zupkas P, Jain A, Kasyan A, Wilkes N, Rajasekaran M.“Small intestinal submucosa as a tunica albuginea graft material.” Journal of Urology 2002;168:1215-1221.

Mulcahy JJ.“Use of penile implants in the constructed neophallus.” International Journal of Impotence Research 2003;15:S129-S131.

Nuininga JE, van Moerkerk H, Hanssen A, Hulsbergen CA, Oosterwijk-Wakka J, Oosterwijk E, de Gier RP, Schalken JA, van Kuppevelt T, Feitz WF.“Rabbit urethra replacement with a defined biomatrix or small intestinal submucosa.” European Urology 2003;44:266-274.

Nuininga JE, van Moerkerk H, Hanssen A, Hulsbergen CA, Oosterwijk-Wakka J, Oosterwijk E, de Gier RPE, Schalken JA, van Kuppevel TH, Feitz WFJ.“A rabbit model to tissue engineer the bladder.” Biomaterials 2004;25:1657-1661.

O'Connor RC, Harding JN, Steinberg GD.“Novel modification of partial nephrectomy technique using porcine small intestine submucosa.” Urology 2002;60:906-909.

O'Connor RC, Holloweel CM, Steinberg GD.“Distal ureteral replacement with tubularized porcine small intestine submucosa.” Urology 2002;60:697x-697xii.

O'Connor RC, Patel RV, Steinberg GD.“Successful repair of a uretero-neobladder stricture using porcine small intestine submucosa.” Journal of Urology 2001;165:1995.

Palminteri E, Berdondini E, Colombo F, Austoni E.“Small intestinal submucosa (SIS) graft urethroplasty: Short-term results.” European Urology 2007;51:1695-1701.

Palminteri E, Berdondini E, Fusco F, De Nunzio C, Salonia A.“Long-term results of small intestinal submucosa graft in bulbar urethral reconstruction.” Urology 2012;79:695-701.

Paradiso M, Sedigh O, Milan GL.“[Plaque surgery for Peyronie's disease: heterologous grafts].” Arch Ital Urol Androl 2003;75:116-118.

Parshotam KG, Barker A, Ahmed S, Gerath J, Orford J.“Urinary bladder auto augmentation using INTEGRA® and SURGISIS®: an experimental model.” Pediatric Surgery International 2010;26:275-280.

Paterson RF, Lifshitz DA, Beck SD, Siqueira TM, Cheng L, Lingeman JE, Shalhav A.“Multilayered small intestinal submucosa is inferior to autologous bowel for laparoscopic bladder augmentation.” Journal of Urology 2002;168:2253-2257.

Pope JC, Davis MM, Smith ER, Walsh MJ, Ellison PK, Rink RC, Kropp BP.“The ontogeny of canine small intestinal submucosa regenerated bladder.” Journal of Urology 1997;158:1105-1110.

Portis AJ, Elbahnasy AM, Shalhav AL, Brewer A, Humphrey P, McDougall EM, Clayman RV.“Laparoscopic augmentation cystoplasty with different biodegradable grafts in an animal model.” Journal of Urology 2000;164:1405-1411.

Portis AJ, Elbahnasy AM, Shalhav AL, Brewer AV, Olweny E, Humphrey PA, McDougall EM, Clayman RV.“Laparoscopic midsagittal hemicystectomy and replacement of bladder wall with small intestinal submucosa and reimplantation of ureter into graft.” Journal of Endourology 2000;14:203-211.

Rahman NU, Minor TX, Deng D, Lue TF.“Combined external urethral bulking and artificial urinary sphincter for urethral atrophy and stress urinary incontinence.” BJU International 2005;95:824-826.

Reddy PP, Barrieras DJ, Wilson G, Bagli DJ, McLorie GA, Khoury AE, Merguerian PA.“Regeneration of functional bladder substitutes using large segment acellular matrix allografts in a porcine model.” Journal of Urology 2000;164:936-941.

Ritchey ML, Ribbeck M.“Successful use of tunica vaginalis grafts for treatment of severe penile chordee in children.” Journal of Urology 2003;170:1574-1576.

Roemer FD.“There isn't an ideal smooth-surface material--yet: the history and future of urologic materials.” Journal of Endourology 2000;14:1-4.

Rolle L, Ceruti C, Timpano M, Sedigh O, Destefanis P, Galletto E, Falcone M, Fontana D.“A new, innovative, lengthening surgical procedure for peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: The "Sliding Technique."” Journal of Sexual Medicine 2012;9:2389-2395.

Rolle L, Tamagnone A, Bollito E, Ceruti C, Timpano M, Negro CL, Galletto E, Fontana D.“[Could plaque excision surgery with sis graft induce a new fibrotic reaction in la Peyronie's disease patients?]” Archivio italiano di urologia, andrologia 2007;79:167-169.

Rotariu P, Yohannes P, Alexianu M, Gershbaum D, Pinkashov D, Morgenstern N, Smith AD.“Reconstruction of rabbit urethra with Surgisis® small intestinal submucosa.” Journal of Endourology 2002;16:617-620.

Roth CC, Bell CH, Woodson B, Schultz AD, Palmer BW, Frimberger D, Fung KM, Lin HK, Kropp BP.“Temporal differentiation and maturation of regenerated rat urothelium.” BJU International 2009;103:836-841.

Roth CC, Bell CH, Woodson B, Schultz AD, Palmer BW, Frimberger D, Fung KM, Lin HK, Kropp BP.“Temporal differentiation and maturation of regenerated rat urothelium.” BJU International 2008 Nov 19. [Epub]

Roth CC, Mondalek FG, Kibar Y, Ashley RA, Bell CH, Califano JA, Madihally SV, Frimberger D, Lin HK, Kropp BP.“Bladder regeneration in a canine model using hyaluronic acid-poly(lactic-co-glycolic-acid) nanoparticle modified porcine small intestinal submucosa.” BJU International 2011;108:148-155.

Samli M, Singla AK.“Absorbable versus nonabsorbable graft: outcome of bone anchored male sling for post-radical prostatectomy incontinence.” Journal of Urology 2005;173:499-502.

Schaefer M, Kaiser A, Stehr M, Beyer HJ.“Bladder augmentation with small intestinal submucosa leads to unsatisfactory long-term results.” Journal of Pediatric Urology 2013 Jan 15. [Epub]

Schnoeller TJ, de Petriconi R, Hefty R, Jentzmik F, Al Ghazal A, Steinestel J, Mueller J, Zengerling F, Schrader M, Schrader AJ.“[The use of Surgisis® optimizes and simplifies partial nephrectomy for large renal tumors.]” Urologe A 2013;52:246-251.

Schnoeller TJ, de Petriconi R, Hefty R, Jentzmik F, Waalkes S, Zengerling F, Schrader M, Schrader AJ.“Partial nephrectomy using porcine small intestinal submucosa.” World Journal of Surgical Oncology 2011;9:126.

Schultheiss D, Gabouev AI, Cebotari S, Tudorache I, Walles T, Schlote N, Wefer J, Kaufmann PM, Haverich A, Jonas U, Stief CG, Mertsching H.“Biological vascularized matrix for bladder tissue engineering: matrix preparation, reseeding technique and short-term implantation in a porcine model.” Journal of Urology 2005;173:276-280.

Seth A, Chung YG, Gil ES, Tu D, Franck D, Di Vizio D, Adam RM, Kaplan DL, Estrada CR Jr, Mauney JR.“The performance of silk scaffolds in a rat model of augmentation cystoplasty.” Biomaterials 2013;34:4758-4765.

Shalhav AL, Elbahnasy AM, Bercowsky E, Kovacs G, Brewer A, Maxwell KL, McDougall EM, Clayman RV.“Laparoscopic replacement of urinary tract segments using biodegradable materials in a large-animal model.” Journal of Endourology 1999;13:241-244.

Sharma AK, Bury MI, Marks AJ, Fuller NJ, Meisner JW, Tapaskar N, Halliday LC, Matoka DJ, Cheng EY.“A non-human primate model for urinary bladder regeneration utilizing autologous sources of bone marrow derived mesenchymal stem cells.” Stem Cells 2011;29:241-250.

Shokeir AA.“Bladder regeneration: between the idea and reality.” BJU International 2002;89:186-193.

Shukla D, Box GN, Edwards RA, Tyson DR.“Bone marrow stem cells for urologic tissue engineering.” World Journal of Urology 2008;26:341-349.

Simon J, de Petriconi R, Meilinger M, Hautmann RE, Bartsch G Jr.“Optimized haemostasis in nephron-sparing surgery using small-intestine submucosa.” BMC Urology 2008;8:8.

Siracusano S, Ciciliato S, Lampropoulou N, Cucchi A, Visalli F, Talamini R.“Porcine small intestinal submucosa implant in pubovaginal sling procedure on 48 consecutive patients: long-term results.” European Journal of Obstetrics Gynecology and Reproductive Biology 2011;158:350-353.

Smith TG, Gettman M, Lindberg G, Napper C, Pearle MS, Cadeddu JA.“Ureteral replacement using porcine small intestine submucosa in a porcine model.” Urology 2002;60:931-934.

Soergel TM, Cain MP, Kaefer M, Gitlin J, Casale AJ, Davis MM, Rink RC.“Complications of small intestinal submucosa for corporal body grafting for proximal hypospadias.” Journal of Urology 2003;170:1577-1579.

Sofer M, Rowe E, Forder DM, Denstedt JD.“Ureteral segmental replacement using multilayer porcine small-intestinal submucosa.” Journal of Endourology 2002;16:27-31.

Staerman F, Pierrevelcin J, Ripert T, Menard J.“Medium-term follow-up of plaque incision and porcine small intestinal submucosal grafting for Peyronie's disease.” International Journal of Impotence Research 2010;22:343-348.

Trost L, Elliott D.“Small intestinal submucosa urethral wrap at the time of artificial urinary sphincter placement as a salvage treatment option for patients with persistent/recurrent incontinence following multiple prior sphincter failures and erosions.” Urology 2012;79:933-938.

Tu DD, Seth A, Gil ES, Kaplan DL, Mauney JR, Estrada CR Jr.“Evaluation of biomaterials for bladder augmentation using cystometric analyses in various rodent models.” Journal of Visualized Experiments 2012;(66). pii: 3981.

Vandevord PJ, Broadrick KM, Krishnamurthy B, Singla AK.“A comparative study evaluating the in vivo incorporation of biological sling materials.” Urology 2010;75:1228-1233.

Vaughan-Shaw PG, Cheung T, Knight JS, Nichols PH, Pilkington SA, Mirnezami AH.“Surgical outcomes and patient satisfaction after dermal, pericardial, and small intestinal submucosal grafting for Peyronie's Disease.” Journal of Sexual Medicine 2007;4:1500-1508.

Vaught JD, Kropp BP, Sawyer BD, Rippy MK, Badylak SF, Shannon HE, Thor KB.“Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: Functional innervation and receptor expression.” Journal of Urology 1996;155:374-378.

Villoldo GM, Loresi M, Giudice C, Damia O, Moldes JM, Debadiola F, Barbich M, Argibay P.“Histologic changes after urethroplasty using small intestinal submucosa unseeded with cells in rabbits with injured urethra.” Urology 2013 Apr 9. [Epub]

Wang DS, Anderson DA, Fretz PC, Nguyen TT, Winfield HN.“Laparoscopic augmentation cystoplasty: a comparison between native ileum and small intestinal submucosa in the porcine model.” BJU International 2007;99:628-631.

Weiser AC, Franco I, Herz DB, Silver RI, Reda EF.“Single layered small intestinal submucosa in the repair of severe chordee and complicated hypospadias.” Journal of Urology 2003;170:1593-1595.

Wunsch L, Ehlers EM, Russlies M.“Matrix testing for urothelial tissue engineering.” European Journal of Pediatric Surgery 2005;15:164-169.

Xie H, Shaffer BS, Wadia Y, Gregory KW.“Use of reconstructed small intestine submucosa for urinary tract replacement.” ASAIO Journal 2000;46:268-272.

Xu YM, Fu Q, Sa YL, Zhang J, Song LJ, Feng C.“Outcome of small intestinal submucosa graft for repair of anterior urethral strictures.” International Journal of Urology 2012 Nov 7 [Epub]

Yohannes P, Rotariu P, Liatsikos E, Malik A, Alexianu M, Pinkasov D, Morgenstern N, Lee BR, Smith AD.“Role of acellular collagen matrix (Surgisis® ) in the endoscopic management of ureteropelvic junction obstruction.” Journal of Endourology 2002;16:549-556.

Zhang F, Liao L.“Tissue-engineered cystoplasty augmentation for treatment of neurogenic bladder using small intestinal submucosa: An exploratory study 2014 Mar 25. [Epub]” Journal of Urology 2014 Mar 25 [Epub]

Zhang F, Liao L.“Tissue-engineered cystoplasty augmentation for treatment of neurogenic bladder using small intestinal submucosa: An exploratory study 2014 Mar 25. [Epub]” Journal of Urology 2014 Mar 25 [Epub]

Zhang Y, Kropp BP, Lin HK, Cowan R, Cheng EY.“Bladder regeneration with cell-seeded small intestinal submucosa.” Tissue Engineering 2004;10:181-188.

Zhang Y, Lin HK, Frimberger D, Epstein RB, Kropp BP.“Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladder.” BJU International 2005;96:1120-1125.

Zhang Y, Liu G, Kropp BP.“Re-epithelialization of demucosalized stomach patch with tissue-engineered urothelial mucosa combined with Botox A in bladder augmentation.” BJU International 2012;110:e106-e112.

Vascular Surgery

References noted with a yellow highlight refer to human patients.

Badylak S, Obermiller J, Geddes L, Matheny R.“Extracellular matrix for myocardial repair.” Heart Surgery Forum 2003;6:E20-E26.

Badylak SF, Coffey AR, Lantz GC, Tacker WA, Geddes LA.“Comparison of the resistance to infection of intestinal submucosa arterial autografts versus polytetrafluoroethylene arterial prostheses in a dog model.” Journal of Vascular Surgery 1994;3:465-472.

Badylak SF, Kochupura PV, Cohen IS, Doronin SV, Saltman AE, Gilbert TW, Kelly DJ, Ignotz RA, Gaudette GR.“The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium.” Cell Transplantation 2006;15 Suppl 1:S29-40.

Badylak SF, Lantz GC, Coffey A, Geddes LA.“Small intestinal submucosa as a large diameter vascular graft in the dog.” Journal of Surgical Research 1989;47:74-80.

Baltoyannis G, Mitsis M, Nathanael C, Batsis C, Pappas S, Nastos D, Kappas AM.“Submucosa of canine small intestine as an alternative medium-diameter autogenous arterial graft.” International Angiology 2000;19:280-284.

Boni L, Chalajour F, Sasaki T, Snyder RL, Boyd WD, Riemer RK, Reddy VM.“Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential” Journal of Thoracic and Cardiovascular Surgery 2012;144:963-969.

Boyd WD, Johnson WE 3rd, Sultan PK, Deering TF, Matheny RG.“Pericardial reconstruction using an extracellular matrix implant correlates with reduced risk of postoperative atrial fibrillation in coronary artery bypass surgery patients.” Heart Surgery Forum 2010;13:E311-316.

Brountzos E, Pavcnik D, Timmermans HA, Corless C, Uchida BT, Nihsen ES, Nakata M, Schoder M, Kaufman JA, Keller FS, Rosch J.“Remodeling of suspended small intestinal submucosa venous valve: an experimental study in sheep to assess the host cells' origin.” Journal of Vascular and Interventional Radiology 2003;14:349-356.

Cooley BC.“Invited discussion of 'Experimental evaluation of small intestinal submucosa as a microvascular graft material' (C.D. Prevel, B.L. Eppley, M. McCarty, J.R. Jackson, S.L. Voytik, M.C. Hiles, S.F. Badylak, page 586)” Microsurgery 1994;15:592-593.

Egusa S.“Experimental study on vascular graft II. Replacement of inferior vena cava and abdominal aorta with the autogenous segment of small intestinal submucosa.” Acta medica Okayama 1968;22:153-165.

Fallon A, Goodchild T, Wang R, Matheny RG.“Remodeling of extracellular matrix patch used for carotid artery repair.” Journal of Surgical Research 2012;175:e25-e34.

Fallon AM, Goodchild TT, Cox JL, Matheny RG.“In vivo remodeling potential of a novel bioprosthetic tricuspid valve in an ovine model.” Journal of Thoracic and Cardiovascular Surgery 2013 Dec 19. [Epub]

Ferrell S, Werner J, Kyles A, Lowenstine L, Kass P, Tell L.“Evaluation of a collagen patch as a method of enhancing ventriculotomy healing in Japanese quail (Coturnix coturnix japonica).” Veterinary Surgery 2003;32:103-112.

Greca FH, Noronha L, Costa FD, Souza Filho ZA, Soccol AT, Feres AN, Duda JR, Adams E.“[Comparative study of the biocompatibility of the porcine intestinal submucosa and bovine pericardium used as grafts in the inferior cava vein of dogs.]” Acta Chirgica Brasiliera 2005;20:317-322.

Han B, Fan C, Liu S.“[Effects of different stress environments on growth of tissue engineering blood vessels].” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2007;21:302-306.

Herbert ST, Badylak SF, Geddes LA, Hillberry B, Lantz GC, Kokini K.“Elastic modulus of prepared canine jejunum, a new vascular graft material.” Annals of Biomedical Engineering 1993;21:727-733.

Hiles MC, Badylak SF, Lantz GC, Kokini K, Geddes LA, Morff RJ.“Mechanical properties of xenogeneic small-intestinal submucosa when used as an aortic graft in the dog.” Journal of Biomedical Materials Research 1995;29:883-891.

Hinds MT, Rowe RC, Ren Z, Teach J, Wu PC, Kirkpatrick SJ, Breneman KD, Gregory KW, Courtman DW.“Development of a reinforced porcine elastin composite vascular scaffold.” Journal of Biomedical Materials Research 2006;77:458-469.

Hiraki T, Pavcnik D, Uchida BT, Timmermans HA, Wu RH, Niyyati M, Keller FS, Rosch J.“Small intestinal submucosa sandwich Zilver stent-grafts for TIPS: Experimental pilot study in swine.” Minimally Invasive Therapy and Allied Technologies 2005;14:32-38.

Huynh T, Abraham G, Murray J, Brockbank K, Hagen PO, Sullivan S.“Remodeling of an acellular collagen graft into a physiologically responsive neovessel.” Nature Biotechnology 1999; 17:1083-1086.

Ishii S, Sato M, Sonomura T, Yamada K, Tanihata H, Ishikawa H, Terada M, Sahara S, Kawai N, Kimura M, Mori I.“Optimal covering material for stent-grafts placed in the portal vein in a canine model.” Cardiovascular and Interventional Radiology 2005;28:624-631.

Jux C, Wohlsein P, Bruegmann M, Zutz M, Franzbach B, Bertram H.“A new biological matrix for septal occlusion.” Journal of Interventional Cardiology 2003;16:149-152.

Kim MD, Hoppe H, Pavcnik D, Kaufman JA, Uchida BT, Correa LO, Timmermans HA, Park WK, Corless CL, Keller FS, Rosch J.“Percutaneous vein occlusion with small intestinal submucosa: An experimental pilot study in swine and sheep.” Cardiovascular and Interventional Radiology 2007;30:725-730.

Kim SS, Kaihara S, Benvenuto MS, Kim BS, Mooney DJ, Vacanti JP.“Small intestinal submucosa as a small-caliber venous graft: a novel model for hepatocyte transplantation on synthetic biodegradable polymer scaffolds with direct access to the portal venous system.” Journal of Pediatric Surgery 1999;34:124-128.

Kochupura PV, Azeloglu EU, Kelly DJ, Doronin SV, Badylak SF, Krukenkamp IB, Cohen IS, Gaudette GR.“Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function.” Circulation 2005;112:I144-I149.

Lantz GC, Badylak SF, Coffey AC, Geddes LA, Blevins WE.“Small intestinal submucosa as a small diameter arterial graft in the dog.” Journal of Investigative Surgery 1990;3:217-227.

Lantz GC, Badylak SF, Coffey AC, Geddes LA, Sandusky GE.“Small intestinal submucosa as a superior vena cava graft in the dog.” Journal of Surgical Research 1992;53:175-181.

Lantz GC, Badylak SF, Hiles MC, Coffey AC, Geddes LA, Kokini K, Sandusky GE, Morff RJ.“Small intestinal submucosa as a vascular graft: a review.” Journal of Investigative Surgery 1993;6:297-310.

Liao B, Deng L, Wang F.“[Effects of bone marrow mesenchymal stem cells enriched by small intestinal submucosal films on cardiac function and compensatory circulation after myocarcadial infarction in goats.]” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006;20:1248-1252.

Marshall SE, Tweedt SM, Greene CH, Ballestas LY, Bunning KR, Costa LE, Harrison TD, Higgins CM, Hoertz MJ, Hollobaugh DA, Jaffe JS, Koenig GJ, Lewbart“An alternative to synthetic aortic grafts using jejunum.” Journal of Investigative Surgery 2000;13:333-341.

Matheny RG, Hutchison ML, Dryden PE, Hiles MC, Shaar CJ.“Porcine small intestine submucosa as a pulmonary valve leaflet substitute.” Journal of Heart Valve Disease 2000;9:769-775.

McCready RA, Divelbiss JL, Bryant MA, Denardo AJ, Scott JA.“Endoluminal repair of carotid artery pseudoaneurysms: a word of caution.” Journal of Vascular Surgery 2004;40:1020-1023.

McCready RA, Hodde J, Irwin RJ, Coffey AC, Divelbiss JL, Bryant MA, Chitwood RW, Paget DS, Chess BA.“Pseudoaneursym formation in a subset of patients with small intestinal submucosa biologic patches after carotid endarterectomy” Journal of Vascular Surgery 2005;41:782-788.

Nakata M, Pavcnik D, Uchida BT, VanAlstine W, Timmermans HA, Toyota N, Terada M, Brountzos E, Kaufman JA, Keller FS, Rosch J.“Comparison of small intestinal submucosa-covered and noncovered nitinol stents with PTFE endografts in injured ovine femoral arteries: A pilot study.” Cardiovascular and Interventional Radiology 2003;26:459-467.

Nemcova S, Noel A A, Jost C J, Gloviczki P, Miller V M, Brockbank KGM.“Evaluation of a xenogeneic acellular collagen matrix as a small-diameter vascular graft in dogs-preliminary observations.” Journal of Investigative Surgery 2001;14:321-330.

Nerem RM, Seliktar D.“Vascular Tissue Engineering.” Annual Review of Biomedical Engineering 2001;3:225-243.

Ni RF, Kranokpiraksa P, Pavcnik D, Kakizawa H, Uchida BT, Keller FS, Rösch J.“Testing percutaneous arterial closure devices: an animal model.” Cardiovascular and Interventional Radiology 2009;32:313-316.

Ni RF, Kranokpiraksa P, Pavcnik D, Kakizawa H, Uchida BT, Keller FS, Rösch J.“Testing percutaneous arterial closure devices: an animal model.” Cardiovascular and Interventional Radiology 2008 Sep 9. [Epub]

Niyyati M, Petersen BD, Pavcnik D, Uchida BT, Timmermans HA, Hiraki T, Wu RH, Brountzos E, Keller FS, Rosch J.“A Flexible stent with small intestinal submucosa covering for direct intrahepatic portocaval shunt: experimental pilot study in swine.” Cardiovascular and Interventional Radiology 2005;28:215-220.

Okada M, Payne TR, Oshima H, Momoi N, Tobita K, Huard J.“Differential efficacy of gels derived from small intestinal submucosa as an injectable biomaterial for myocardial infarct repair.” Biomaterials 2010;31:7678-7683.

Opitz F, Schenke-Layland K, Cohnert TU, Starcher B, Halbhuber KJ, Martin DP, Stock UA.“Tissue engineering of aortic tissue: dire consequence of suboptimal elastic fiber synthesis in vivo.” Cardiovascular Research 2004;63:719-730.

Ota T, Gilbert TW, Badylak SF, Schwartzman D, Zenati MA.“Electromechanical characterization of a tissue-engineered myocardial patch derived from extracellular matrix.” Journal of Thoracic and Cardiovascular Surgery 2007;133:979-985.

Padalino MA, Castellani C, Dedja A, Fedrigo M, Vida VL, Thiene G, Stellin G, Angelini A.“Extracellular matrix graft for vascular reconstructive surgery: evidence of autologous regeneration of the neoaorta in a murine model.” European Journal of Cardiothoracic Surgery 2012;42:e128-e135.

Park JW, Pavcnik D, Uchida BT, Timmermans H, Corless CL, Yamakado K, Yamada K, Keller FS, Rosch J.“Small intestinal submucosa covered expandable Z stents for treatment of tracheal injury: an experimental pilot study in swine.” Journal of Vascular and Interventional Radiology 2000;11:1325-1330.

Pavcnik D, Kaufman J, Uchida B, Correa L, Hiraki T, Kyu SC, Keller FS, Rosch J.“Second-generation percutaneous bioprosthetic valve: A short-term study in sheep.” Journal of Vascular Surgery 2004;40:1223-1227.

Pavcnik D, Kaufman JA, Uchida BT, Case B, Correa LO, Goktay AY, Hamada A, Keller FS, Rosch J.“Significance of spatial orientation of percutaneously placed bioprosthetic venous valves in an ovine model.” Journal of Vascular and Interventional Radiology 2005;16:1511-1516.

Pavcnik D, Machan L, Uchida B, Kaufman J, Keller FS, Rosch J.“Percutaneous prosthetic venous valves: Current state and possible applications.” Techncs in Vascular and Interventional Radiology 2003;6:137-143.

Pavcnik D, Obermiller J, Uchida BT, Van Alstine W, Edwards JM, Landry GJ, Kaufman JA, Keller FS, Rösch J.“Angiographic evaluation of carotid artery grafting with prefabricated small-diameter, small-intestinal submucosa grafts in sheep.” Cardiovascular and Interventional Radiology 2009;32:106-113.

Pavcnik D, Obermiller J, Uchida BT, Van Alstine W, Edwards JM, Landry GJ, Kaufman JA, Keller FS, Rösch J.“Angiographic evaluation of carotid artery grafting with prefabricated small-diameter, small-intestinal submucosa grafts in sheep.” Cardiovascular and Interventional Radiology 2008 Oct 18. [Epub]

Pavcnik D, Takulve K, Uchida BT, Pavcnik Arnol M, VanAlstine W, Keller F, Rösch J.“Biodisk: a new device for closure of patent foramen ovale: a feasibility study in swine.” Cathetarization and Cardiovascular Interventations 2010;75:861-867.

Pavcnik D, Tekulve K, Uchida BT, Luo ZH, Jeromel M, Van Alstine WG, Keller FS, Rösch J.“Double BioDisk: a new bioprosthetic device for transcatheter closure of atrial septal defects - a feasibility study in adult sheep.” Radiology and Oncology 2012;46:89-96.

Pavcnik D, Uchida B, Kaufman J, Hinds M, Keller FS, Rösch J.“Percutaneous management of chronic deep venous reflux: review of experimental work and early clinical experience with bioprosthetic valve.” Vascular Medicine 2008;13:75-84.

Pavcnik D, Uchida B, Timmermans H, Keller FS, Rosch J.“Square stent: A new self-expandable endoluminal device and its applications.” Cardiovascular and Interventional Research 2001;24:207-217.

Pavcnik D, Uchida BT, Timmermans H, Corless CL, Keller FS, Rosch J.“Aortic and venous valve for percutaneous insertion.” Minimally Invasive Therapeutics & Allied Technology 2000;9:287-292.

Pavcnik D, Uchida BT, Timmermans H, Corless CL, Loriaux M, Keller FS, Rosch J.“The square stent-based large vessel occluder: an experimental pilot study.” Journal of Vascular and Interventional Radiology 2000;11:1227-1234.

Pavcnik D, Uchida BT, Timmermans HA, Corless CL, O'hara M, Toyota N, Moneta GL, Keller FS, Rosch J.“Percutaneous bioprosthetic venous valve: A long-term study in sheep.” Journal of Vascular Surgery 2002;35:598-602.

Peng H, Schlaich EM, Row S, Andreadis ST, Swartz DD.“A novel ovine ex vivo arteriovenous shunt model to test vascular implantability.” Cells, Tissues, and Organs 2012;195:108-121.

Prevel CD, Eppley BL, McCarty M, Jackson JR, Voytik SL, Hiles MC, Badylak SF.“Experimental evaluation of small intestinal submucosa as a microvascular graft material.” Microsurgery 1994;15:586-591.

Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF.“Extracellular matrix scaffold for cardiac repair.” Circulation 2005;112:I135-I143.

Robotin-Johnson MC, Swanson PE, Johnson DC, Schuessler RB, Cox JL.“An experimental model of small intestinal submucosa as a growing vascular graft.” Journal of Thoracic and Cardiovascular Surgery 1998;116:805-811.

Roeder RA, Lantz GC, Geddes LA.“Mechanical remodeling of small-intestine submucosa small-diameter vascular grafts--a preliminary report.” Biomedical Instrumentation & Technology 2001;35:110-120.

Rosen M, Roselli EE, Faber C, Ratliff NB, Ponsky JL, Smedira NG.“Small intestinal submucosa intracardiac patch: an experimental study.” Surgical Innovations 2005;12:227-231.

Rotthoff, C, Bilcin I, Mahjour M, Zimmermann KU, Zinganell K.“Aortenersatz durch mehrschichtige Submucosaprothesen aus heterologem Dunndarm.” Bull Soc Int Chirurgie 1969;256-260.

Ruiz CE, Iemura M, Medie S, Varga P, Van Alstine WG, Mack S, Deligio A, Fearnot N, Beier UH, Pavcnik D, Hijazi ZM, Kiupel M.“Transcatheter placement of a low-profile biodegradable pulmonary valve made of small intestinal submucosa: A long-term study in a swine model.” Journal of Thoracic and Cardiovascular Surgery 2005;130:477-484.

Sandusky GE, Badylak SF, Morff RJ, Johnson WD, Lantz G.“Histologic findings after in vivo placement of small intestine submucosal vascular grafts and saphenous vein grafts in the carotid artery in dogs.” American Journal of Pathology 1992;140:317-324.

Sandusky GE, Lantz GC, Badylak FS.“Healing comparison of small intestine submucosa and ePTFE grafts in the canine carotid artery.” Journal of Surgical Research 1995;58:415-420.

Schmidt CE, Baier JM.“Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering.” Biomaterials 2000;21:2215-2231.

Schoder M, Pavcnik D, Uchida BT, Corless C, Timmermans HA, Yin Q, Brountzos E, Nakata M, Hiraki T, Niyyati M, Kaufman JA, Keller FS, Rosch J.“Small intestinal submucosa aneurysm sac embolization for endoleak prevention after abdominal aortic aneurysm endografting: a pilot study in sheep.” Journal of Vascular and Interventional Radiology 2004;15:69-83.

Shell DH 4th, Croce MA, Cagiannos C, Jernigan TW, Edwards N, Fabian TC.“Comparison of small-intestinal submucosa and expanded polytetrafluoroethylene as a vascular conduit in the presence of gram-positive contamination.” Annals of Surgery 2005;241:995-1004.

Stelly M, Stelly TC.“Histology of CorMatrix bioscaffold 5 years after pericardial closure.” Annals of Thoracic Surgery 2013;96:e127-129.

Stock UA, Degenkolbe I, Attmann T, Schenke-Layland K, Freitag S, Lutter G.“Prevention of device-related tissue damage during percutaneous deployment of tissue-engineered heart valves.” Journal of Thoracic and Cardiovascular Surgery 2006;131:1323-1330.

Toeg HD, Tiwari-Pandey R, Seymour R, Ahmadi A, Crowe S, Vulesevic B, Suuronen EJ, Ruel M.“Injectable small intestine submucosal extracellular matrix in an acute myocardial infarction model.” Annals of Thoracic Surgery 2013 Sep 28. [Epub]

Toyota N, Pavcnik D, VanAlstine W, Uchida BT, Timmermans HA, Yin Q, Kaufman JA, Keller FS, Ito K, Rosch J.“Comparison of small intestinal submucosa-covered and noncovered nitinol stents in sheep iliac arteries: a pilot study.” Journal of Vascular and Interventional Radiology 2002;13:489-498.

Tucker OP, Syburra T, Augstburger M, Van Melle G, Gebhard S, Bosman F, Von Segesser LK.“Small intestine without mucosa as a growing vascular conduit: A porcine experimental study.” Journal of Thoracic and Cardiovascular Surgery 2002;124:1165-1175.

Wang X, Li J, Zhang H, Zhang Y.“Evaluation of the small intestinal submucosa covered stent in preventing restenosis after percutaneous transluminal angioplasty in the swine.” European Journal of Radiology 2012;81:e281-e287.

Weber SS, Annenberg AJ, Wright CB, Braverman TS, Mesh CL.“Early pseudoaneurysm degeneration in biologic extracellular matrix patch for carotid repair.” Journal of Vascular Surgery 2013 [E-pub; have copy].

White JK, Agnihotri AK, Titus JS, Torchiana DF.“A stentless trileaflet valve from a sheet of decellularized porcine small intestinal submucosa.” Annals of Thoracic Surgery 2005;80:704-707.

Wiemer P, Gruys E, van Hoeck B.“A study of seven different types of grafts for jugular vein transplantation in the horse.” Research in Veterinary Science 2005;79:211-217.

Witt RG, Raff G, Van Gundy J, Rodgers-Ohlau M, Si MS.“Short-term experience of porcine small intestinal submucosa patches in paediatric cardiovascular surgery.” European Journal of Cardiothoracic Surgery 2013;44:72-76.

Yamada K, Pavcnik D. Uchida BT, Timmermans HA, Corless CL, Yin Q, Yamakado K, Park JW, Rosch J, Keller FS, Sato M, Yamada R.“Endoluminal treatment of ruptured abdominal aortic aneurysm with small intestinal submucosa sandwich endografts: A pilot study in sheep.” CardioVascular and Interventional Radiology 2001;24:72-78.

Yanagawa B, Rao V, Yau TM, Cusimano RJ.“Initial experience with intraventricular repair using CorMatrix Extracellular Matrix.” Innovations (Phila) 2013;8:348-352.

Yavuz K, Geyik S, Pavcnik D, Uchida BT, Corless CL, Hartley DE, Goktay A, Correa LO, Timmermans H, Hodde JP, Kaufman JA, Keller FS, Rosch J.“Comparison of the endothelialization of small intestinal submucosa, dacron, and expanded polytetrafluoroethylene suspended in the thoracoabdominal aorta in sheep.” Journal of Vascular and Interventional Radiology 2006;17:873-882.

Zaidi AH, Nathan M, Emani S, Baird C, Del Nido PJ, Gauvreau K, Harris M, Sanders SP, Padera RF“Preliminary experience with porcine intestinal submucosa (CorMatrix) for valve reconstruction in congenital heart disease: Histologic evaluation of explanted valves. ” Journal of Thoracic and Cardiovascular Surgery 2014 Mar 2

Zaidi AH, Nathan M, Emani S, Baird C, Del Nido PJ, Gauvreau K, Harris M, Sanders SP, Padera RF“Preliminary experience with porcine intestinal submucosa (CorMatrix) for valve reconstruction in congenital heart disease: Histologic evaluation of explanted valves. ” Journal of Thoracic and Cardiovascular Surgery 2014 Mar 2

Zhao ZQ, Puskas JD, Xu D, Wang NP, Mosunjac M, Guyton RA, Vinten-Johansen J, Matheny R.“Improvement in cardiac function with small intestine extracellular matrix is associated with recruitment of C-kit cells, myofibroblasts, and macrophages after myocardial infarction.” Journal of the American College of Cardiology 2010;55:1250-1261.

Veterinary

References noted with a yellow highlight refer to human patients.

Andreoni AA, Voss K.“Reconstruction of a large diaphragmatic defect in a kitten using small intestinal submucosa (SIS).” Journal of Feline Medicine and Surgery 2009;11:1019-1022.

Arthur EG, Fox DB, Essman SC, Turnquist S, Bondy PJ“Surgical treatment of noncommunicating duplication of the colon in a dog.” Journal of the American Veterinary Medical Association 2003;223:210-214.

Bussieres M, Krohne SG, Stiles J, Townsend WM.“The use of porcine small intestinal submucosa for the repair of full-thickness corneal defects in dogs, cats and horses.” Veterinary Opthalmology 2004;7:352-359.

Clerc B.“Treatment of corneal necrosis in the cat by means of keratectomy and the lamellar graft of porcine intestinal submucosal tissue (SIS).” Journal de médecine et de chirurgie pratiques 2002;37:227-233.

de Castro Marques AI, Hipwell F, Yool DA.“The use of porcine small-intestinal submucosa for abdominal wall reconstruction--a clinical case.” Journal of Small Animal Practice 2009;50:619-623.

Dressel C, Furst A, Imhof A, Brehm W, Auer J.“Clinical use of Small Intestine Submucosa in wound repair in 11 horses.” Wiener Tierarztliche Monatsschrift 2004;91:142-150.

Featherstone H, Sansom J.“Intestinal submucosa repair in two cases of feline ulcerative keratitis.” The Veterinary Record 2000;146:136-138.

Featherstone HJ, Sansom J, Heinrich CL.“The use of porcine small intestinal submucosa in ten cases of feline corneal disease.” Veterinary Ophthalmology 2001;4:147-153.

Featherstone HJ, Sansom J.“Feline corneal sequestra: a review of 64 cases (80 eyes) from 1993 to 2000.” Veterinary Ophthalmology 2004;7:213-227.

Gomez JH, Schumacher J, Lauten SD, Sartin EA, Hathcock TL, Swaim SF.“Effects of 3 biologic dressings on healing of cutaneous wounds on the limbs of horses.” Canadian Journal of Veterinary Research 2004;68:49-55.

Hernandez-Divers SJ, Hernandez-Divers SM.“Xenogeneic grafts using porcine small intestinal submucosa in the repair of skin defects in 4 birds.” Journal of Avian Medicine & Surgery 2003;17:224-234.

Hollingsworth SR.“Corneal surgical techniques.” Clinical Techniques in Small Animal Practice 2003;18:161-167.

Lee AJ, Chung WH, Kim DH, Lee KP, Suh HJ, Do SH, Eom KD, Kim HY.“Use of canine small intestinal submucosa allograft for treating perineal hernias in two dogs.” Journal of Veterinary Science 2012;13:327-330.

Lewin GA.“Repair of a full thickness corneoscleral defect in a German shepherd dog using porcine small intestinal submucosa.” Journal of Small Animal Practice 1999;40:340-342.

Liptak JM, Brebner NS.“Hemidiaphragmatic reconstruction with a transversus abdominis muscle flap after resection of a solitary diaphragmatic mesothelioma in a dog.” Journal of the American Veterinary Medical Association 2006;228:1204-1208.

Powers MY, Campbell BG, Weisse C.“Porcine small intestinal submucosa augmentation urethroplasty and balloon dilatation of a urethral stricture secondary to inadvertent prostatectomy in a dog.” Journal of the American Animal Hospital Association 2010;46:358-365.

Sheahan DE, Gillian TD. “Reconstructive cranioplasty using a porcine small intestinal submucosal graft.” Journal of Small Animal Practice 2008;49:257-259.

Thiel C, Fischer A, Kramer M, Lautersack O.“Surgical therapy of perineal hernia in dogs by the use of Small Intestinal Submucosa (SIS): a retrospective study].” Tierarztl Prax Ausg K Kleintiere Heimtiere 2010;38:71-78.

Wood JD, Simmons-Byrd A, Spievack AR, Badylak SF.“Use of a particulate extracellular matrix bioscaffold for treatment of acquired urinary incontinence in dogs.” Journal of the American Veterinary Medical Association 2005;226:1095-1097.