Dr. Ally-Khan Somani reviews the use of small intestinal submucosa (SIS) in complex and surgical wounds
Dr. Somani also describes the treatment of three patients with SIS following Mohs surgery.
Dr. Somani, Assistant Professor of Clinical Dermatology at Indiana University, follows the TIMERS framework to support the use of advanced wound treatments such as SIS for the stalled closure of wounds.1 In this article, he reviews wound healing and the use of SIS to aid in wound closure. He also reviews previously published case studies describing the use of SIS for traumatic and necrotic wounds, post-operative sites, dermatological diseases (such as dystrophic epidermolysis bullosa), and partial-thickness burns.
Dr. Somani includes descriptions of three patients treated with SIS after Mohs surgery. The article discusses the advantages of using SIS: pain reduction, reduced formation of scar contractures, off-the-shelf availability for immediate coverage, enhanced granulation for delayed skin graft or substitute for STSG, cost effectiveness, and shorter times to epithelialization and healing. Dr. Somani ends the review by advocating for a prospective RCT to evaluate the benefits of SIS.
1 Somani, AK. Application expansion of small intestinal submucosa extracellular matrix in complex and surgical wounds. J Wound Care. 2023;32(Sup1a):S20-S27