A panel of specialists recommends small intestine submucosa extracellular matrix (SIS-ECM) as an excellent adjunct to promote healing in a wide range of hard-to-heal wounds.1
Dr. Ally-Khan Somani chaired a panel that found proper use of SIS-ECM leads to optimal results.
SIS-ECM also provides a less invasive alternative for healing acute surgical wounds where extensive flaps or grafts might otherwise be considered.
The panel agreed on five points:
- SIS-ECM’s biological properties make it an appropriate adjunct in a wide range of wound indications.
- SIS-ECM delivers several key benefits that are relevant to a variety of wound indications, including mixed-etiology ulcers, postoperative wounds, diabetic foot ulcers, venous leg ulcers, pressure ulcers, and burns.
- SIS-ECM can be appropriate in the management of a range of wound indications; in addition to those listed previously, the panel also mentioned pyoderma gangrenosum, hidradenitis suppurativa, and epidermolysis bullosa.
- SIS-ECM efficacy may be optimized through appropriate use, which the panel then described.
- Expansion of the evidence base would be beneficial, and the panel considered future study designs.
The panel represented diverse fields of wound management and came to a consensus that the benefits of SIS-ECM include faster healing with improved scarring, less wound pain, control of inflammation, and a reduced need for dressing changes.
1 Somani A-K, Atkin L, Bechara FG, et al. Practical applications of small intestine submucosa extracellular matrix (SIS-ECM) an expert panel consensus. J Wound Care. 2023;32(Sup9b):S1-S16.