COOK SIS Technology | Scientific Information

Scientific Information >
Product Information
Ordering Information
Corporate Information

Introduction
Tissue Repair
Mechanism of Action
Safety
Versatility
References

Cook is working with numerous natural tissue substrates to develop advanced biomaterials. One such biomaterial that is being used extensively is small intestinal submucosa, or SIS, a strong, pliable tissue taken from porcine small intestine that provides a scaffold for host cells to replace and repair damaged tissue. SIS is a naturally-occurring, complex matrix that is easy to handle, yet strong enough to hold sutures and provide support for weakened tissue.

As a naturally-derived, extracellular matrix material, SIS is neither synthetic nor chemically cross-linked. SIS is taken from a biological source and is processed to remove all cells. It is biocompatible and safe for human use. It is sterilized to eliminate pathogens and provide a long shelf life.

SIS Origin
Taken from porcine small intestine, the submucosa is found between the mucosal and muscular layers of the small intestine. The submucosal layer provides strength to the intestine through a complex organization of collagen that forms a fibrous matrix. SIS is extracted from the intestine in a manner that removes all cells, but leaves the complex matrix intact.

SIS Composition
As a natural biomaterial, SIS is primarily protein with secondary amounts of carbohydrates and lipids.

SIS is obtained from the intestine using a process that retains the natural composition of matrix molecules such as collagen (Types I, III, VI), glycosaminoglycans, (hyaluronic acid, chondroitin sulfate A and B, heparin, and heparan sulfate), proteoglycans, and glycoproteins (fibronectin), which are known to have important roles in host tissue repair and remodeling.

top | learn more